Nanotechnology-based combinational drug delivery: an emerging approach for cancer therapy

Parhi, Priyambada; Mohanty, Chandana; Sahoo, Sanjeeb K.

doi:10.1016/j.drudis.2012.05.010

Cited by 490 publications

(365 citation statements)

References 63 publications

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“…Because of the heterogeneity and genomic instability of cancer, a single therapeutic agent is often insufficient and the recurrent cancer is subsequently much harder to treat therapeutically. However, the use of a combination of different drugs that target multiple pathways has been considered as an effective strategy for cancer therapy (1,2). Indeed, clinical studies have showed the potential of this approach.…”

Section: Introductionmentioning

confidence: 99%

“…Several related nanoformulations have been further developed and shown to be more efficacious in cancer therapy; the drugs presumably have increased accumulation in local tissues, extended half-life, increased solubility, and less premature release in circulation (6). The emerging approach of nanotechnology-based combinational drug delivery has also been discussed (2). For cancer prevention, nanoformulations of curcumin and other agents have been developed to overcome the low bioavailability of these chemopreventive agents (7)(8)(9)(10).…”

Section: Introductionmentioning

confidence: 99%

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Combination of Chemopreventive Agents in Nanoparticles for Cancer Prevention

Yang

Wang

2013

Cancer Prevention Research

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Carcinogenesis involves multiple genetic and epigenetic alterations, and a single chemopreventive agent may not be sufficient to prevent these events. Therefore, the use of a combination of agents is an attractive approach for cancer chemoprevention. In this issue of the journal, Prabhu and colleagues examined a combination of aspirin, curcumin, and sulforaphane for the prevention of pancreatic cancer in hamsters (beginning page 1015). The novelty of this work is that when aspirin and curcumin were incorporated in nanoparticles and administered orally, in combination with sulforaphane, the effective dosages were decreased by 10-fold in comparison with the free form mixture. In this commentary, the possible mechanisms of synergistic action among multiple chemopreventive agents and the use of stable nanoparticles for oral delivery are discussed. Also discussed is the importance of measuring tissue levels of the chemopreventive agents to understand the mode of action of these nanoparticles and to avoid toxicity.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Combination of Chemopreventive Agents in Nanoparticles for Cancer Prevention

Yang

Wang

2013

Cancer Prevention Research

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“…[1,2]. However, one of the biggest problems in cancer therapy is that of dose-dependent toxicity toward the non-cancerous cells, since poor drug accessibility to the tumor site necessitates high doses of drug treatment [1]. Hence, in order to improve overall survival and quality of life, it is now desired to increase the bioavailability of drugs to the disease sites and to contain the delivery to the cancerous tissues.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Local Drug Delivery Strategy for Cancer Treatment: Use of Biocompatible Sol-Gel-Derived Porous Materials

Cristini-Robbe¹,

Ruyffelaere²,

Dubart³

et al. 2013

NJGC

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Porous silica xerogel materials have been developed to use as drug-release agents to be implanted directly in or near cancerous tissues. In order to test the capacity of the materials to absorb and then to release medicinal substances, a battery of examinations (UV and visible micro-Raman, porosity measurements, UV-visible absorption spectra) have been made using test drug molecules (clotrimazole, primaquine diphosphate and the anti-cancer agent vinblastine sulphate). Results show that the molecules can be post-doped into the gels and the Raman data provide indications of the best conditions for detecting the substances absorbed in the gels. Spectroscopic results show that the drug molecules are released by the xerogel over a period of 10 days. These results are promising for the development of these materials as drug-release agents.

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“…However, there are some hurdles associated with conventional chemotherapeutic agents include limited accessibility of drug to tumor tissues, which requires a higher dose, leading to intolerable cytotoxicity and nonspecific targeting, and consequently repeated treatment with these chemotherapeutic agents can result in resistance to the chemotherapies or development of multi-drug resistance (MDR). 1,2 As a result, in many patients, chemotherapy becomes ineffective in preventing the metastatic spread of the disease through disseminated tumor cells and does not improve life expectancy. 3 In recent years, cancer therapy has evolved to strategically develop new therapeutic approaches such as immunotherapy in order to optimize the chance of cure.…”

Section: Introductionmentioning

confidence: 99%

Multifunctional nanoparticles for cancer immunotherapy

Saleh

Shojaosadati

2016

Human Vaccines & Immunotherapeutics

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During the last decades significant progress has been made in the field of cancer immunotherapy. However, cancer vaccines have not been successful in clinical trials due to poor immunogenicity of antigen, limitations of safety associated with traditional systemic delivery as well as the complex regulation of the immune system in tumor microenvironment. In recent years, nanotechnology-based delivery systems have attracted great interest in the field of immunotherapy since they provide new opportunities to fight the cancer. In particular, for delivery of cancer vaccines, multifunctional nanoparticles present many advantages such as targeted delivery to immune cells, co-delivery of therapeutic agents, reduced adverse outcomes, blocked immune checkpoint molecules, and amplify immune activation via the use of stimuli-responsive or immunostimulatory materials. In this review article, we highlight recent progress and future promise of multifunctional nanoparticles that have been applied to enhance the efficiency of cancer vaccines.

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Nanotechnology-based combinational drug delivery: an emerging approach for cancer therapy

Cited by 490 publications

References 63 publications

Combination of Chemopreventive Agents in Nanoparticles for Cancer Prevention

Combination of Chemopreventive Agents in Nanoparticles for Cancer Prevention

Local Drug Delivery Strategy for Cancer Treatment: Use of Biocompatible Sol-Gel-Derived Porous Materials

Multifunctional nanoparticles for cancer immunotherapy

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