Nanotechnology as a potential tool against drug- and multidrug-resistant tuberculosis

Pérez-Martínez, Damián; Zenteno-Cuevas, Roberto

doi:10.1016/b978-0-12-819811-7.00003-5

Cited by 6 publications

(4 citation statements)

References 75 publications

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“…The development of therapies based on nanomaterials holds promise for treating bacterial infections that are challenging to treat, as they may be able to overcome existing pathways associated with acquired drug resistance ( Khorsandi et al, 2021 ). Furthermore, because of their unique size and physical makeup, nanoparticles can target biofilms and treat infections that are resistant to conventional antibiotics ( Eduardo Pérez-Martínez and Zenteno-Cuevas, 2020 ). Finally, we recommend additional research to seek long-term solutions for MDR and XDR infection prevention and management.…”

Section: Future Prospective For Management Of Mdr and Xdr Infection/s...mentioning

confidence: 99%

Extensively and multidrug-resistant bacterial strains: case studies of antibiotics resistance

Almutairy

2024

Front. Microbiol.

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The development of antibiotic resistance compromises the effectiveness of our most effective defenses against bacterial infections, presenting a threat to global health. To date, a large number of research articles exist in the literature describing the case reports associated with extensively drug-resistant (XDR) and multidrug-resistant (MDR) bacterial strains. However, these findings are scattered, making it time-consuming for researchers to locate promising results and there remains a need for a comparative study to compile these case reports from various geographical regions including the Kingdom of Saudi Arabia. Additionally, no study has yet been published that compares the genetic variations and case reports of MDR and XDR strains identified from Saudi Arabia, the Middle East, Central Europe, and Asian countries. This study attempts to provide a comparative analysis of several MDR and XDR case reports from Saudi Arabia alongside other countries. Furthermore, the purpose of this work is to demonstrate the genetic variations in the genes underlying the resistance mechanisms seen in MDR and XDR bacterial strains that have been reported in Saudi Arabia and other countries. To cover the gap, this comprehensive review explores the complex trends in antibiotic resistance and the growing risk posed by superbugs. We provide context on the concerning spread of drug-resistant bacteria by analyzing the fundamental mechanisms of antibiotic resistance and looking into individual case reports. In this article, we compiled various cases and stories associated with XDR and MDR strains from Saudi Arabia and various other countries including China, Egypt, India, Poland, Pakistan, and Taiwan. This review will serve as basis for highlighting the growing threat of MDR, XDR bacterial strains in Saudi Arabia, and poses the urgent need for national action plans, stewardship programs, preventive measures, and novel antibiotics research in the Kingdom.

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Section: Future Prospective For Management Of Mdr and Xdr Infection/s...mentioning

confidence: 99%

Extensively and multidrug-resistant bacterial strains: case studies of antibiotics resistance

Almutairy

2024

Front. Microbiol.

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“…This global plan is framed in the United Nation Sustainable Development Goals, and establishes the goal to end with the TB as an epidemic disease for 2030, to reduce the deaths by 90% and the number of new cases per 100 000 inhabitants per year worldwide. To achieve these goals it has been recognized that it is essential to increase research and technological development in TB, prioritizing the generation of new vaccines (9,10), shorter and more effective treatment schemes for latent tuberculosis, to identify novel mehcanisms of drug administration (11), as well as the development of rapid diagnostic tests for diagnostic of drug resistance (1).…”

Section: New Molecular Mechanisms Related To Drug Resistance In Tuber...mentioning

confidence: 99%

New molecular mechanisms related to drug resistance in tuberculosis

Zenteno-Cuevas

2022

MIC

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Despite the global efforts tuberculosis (TB) remains as one of the most important infectious disease and with the greatest impact on global public health, this situation has been aggravated in recent decades by the growing problem of drug resistance (DR). Such is the impact of the drug resistant in tuberculosis that would threaten the Millennium Development Goals. In addition to polymorphisms in genes associated with drug resistance in tuberculosis, new mechanisms have being described in recent years. Considering the above, the aim of this mini-review is to give a brief description of the traditional mechanisms related with drug resistance and to describe two of the new mechanisms that will have an important impact in the next future; efflux pumps and DNA damage repair mechanisms.

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“…These come with some limitations, such as giving false-positive results 8 . However, there are currently no biosensing diagnostic devices available for MDR-TB detection [9][10][11] . In addition, there are no optical-based biosensors that have been developed, commercially, for the detection of multi-drug resistant TB mutations 12,13 .…”

Section: Introductionmentioning

confidence: 99%

“…Biosensing devices have been used in various aspects of drug discovery and development, diagnostics, monitoring and management of diseases, the environment, and water quality 11,14 . In essence, biosensing devices are analytical devices used for sensitive, fast, and real-time monitoring and detection of biological molecules.…”

Section: Introductionmentioning

confidence: 99%

Optical biosensing of multidrug-resistant tuberculosis (TB) genes

Chauke,

Ombinda-Lemboumba,

Dube

et al. 2024

Optical Interactions With Tissue and Cells XXXV

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Tuberculosis (TB) remains one of the most important infectious diseases globally, killing approximately 1.5 million people annually. The burden of infection is disproportionately high in low-income and resource-limited settings. This disparity is exacerbated by the emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) Mycobacterium tuberculosis (Mtb), the bacterium that causes TB. Early detection and treatment of TB remain key strategies to reduce the spread and disease progression to drug-resistant forms of TB. However, this is hampered by slow, insensitive diagnostic methods, particularly for the detection of drug-resistant forms and in patients with human immunodeficiency virus infection (HIV). There are currently several rapid TB diagnostics, but most are limited due to costs and accessibility. Several genes, such as catalase-peroxidase (katG) and enoyl reductase (inhA) genes, contain mutations that are responsible for drug resistance. One of the initial objectives of this study was to use an opticalbased system to detect katG and inhA genes. Deoxyribonucleic acid (DNA) probes, specific for katG and inhA, were used as biorecognition elements to capture katG and inhA target DNA. The katG and inhA gene-specific DNA probes were immobilized on a coated glass substrate before the target DNA was introduced for detection. As a negative control, a mismatched probe, unspecific to both genes was used for confirmation of the absence of the two genes in the experimental setup. The optical setup was used for the analysis of the binding interactions occurring on the coated glass substrate. The specificity and sensitivity of the coated glass substrate successfully detected the binding interactions through the changes in the transmitted intensity. The transmitted intensity further indicated the kinetics associated with DNA hybridization occurring between the target DNA and the capture probe. This is the initial step to potentially detecting drug-resistant mutations using optical-based biosensors at a point-of-care setting.

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Nanotechnology as a potential tool against drug- and multidrug-resistant tuberculosis

Cited by 6 publications

References 75 publications

Extensively and multidrug-resistant bacterial strains: case studies of antibiotics resistance

Extensively and multidrug-resistant bacterial strains: case studies of antibiotics resistance

New molecular mechanisms related to drug resistance in tuberculosis

Optical biosensing of multidrug-resistant tuberculosis (TB) genes

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