Nanotechnology and the transdermal routeA state of the art review and critical appraisal

Cevc, Gregor; Vierl, Ulrich

doi:10.1016/j.jconrel.2009.10.016

Cited by 504 publications

(314 citation statements)

References 268 publications

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“…The lipo- some components are biocompatible, but the manufacturing process is complex and has a high cost [8] . The safety of polymers is a big concern, and there are very few polymers that have been approved for injection in clinics [9,10] . Multivesicular liposomes (MVLs), which have a complicated manufacturing process, can only be used for parenteral administration rather than intravenous [11,12] .…”

Section: Introductionmentioning

confidence: 99%

Development of ionic-complex-based nanostructured lipid carriers to improve the pharmacokinetic profiles of breviscapine

Zheng

Shan

et al. 2013

Acta Pharmacol Sin

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Aim: Breviscapine isolated from the Chinese herb Erigeron breviscapus (Vant) Hand-Mazz is widely used to treat cardiovascular and cerebrovascular diseases. The aim of this study was to improve the pharmacokinetic profiles of breviscapine using nanostructured lipid carrier based on an ionic complex formation. Methods: Breviscapine nanostructured lipid carrier (Bre-NLC) was prepared using the thin film homogenization method. The morphology of Bre-NLCs was determined using transmission electron microscopy. The mean particle size, polydispersity index, zeta-potential analysis and entrapment efficiency were analized. In vitro release was studied using the dialysis method. In vitro stability was studied in fresh plasma and liver slurry of rats. In vivo pharmacokinetics was analyzed in rats after intravenous injection of a dose equivalent to breviscapine (10 mg/kg). Results: The Bre-NLCs were spherical with a mean particle size of ~170 nm, a zeta potential of ~20 mV and a high entrapment efficiency of ~89%. Compared with a commercially available solution, a substantial decrease in the cumulative release of breviscapine was found for the Bre-NLCs. The NLC has a significantly protective effect against the liver enzyme degradation of breviscapine. After intravenous administration in rats, the Bre-NLCs exhibited a 32 times increase in the AUC 0-t and a 12 times increase in T 1/2 as compared to the commercially available breviscapine solution. Conclusion:The results demonstrate that the NLC has great potential to use as a novel sustained release system for breviscapine.

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Section: Introductionmentioning

confidence: 99%

Development of ionic-complex-based nanostructured lipid carriers to improve the pharmacokinetic profiles of breviscapine

Zheng

Shan

et al. 2013

Acta Pharmacol Sin

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“…Phospholipid is a crucial element for the formation of a transfersome-based drug delivery system. It is also roughly always true that the fluid-chain vesicles with a rather elastic bilayer promote drug transport across skin obstruction better than the more rigid liposomes [45]. Therefore, nearly all the common phosphatidylcholine (PC) used to organize stretchy liposomes is unsaturated PC (i.e.…”

Section: Regulatory Aspectsmentioning

confidence: 99%

Transfersomes as versatile and flexible nano-vesicular carriers in skin cancer therapy: the state of the art

Rai¹,

Pandey²,

Rai³

2017

Nano Reviews & Experiments

196

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Introduction: The skin acts as a barrier and prevents transcutaneous delivery of therapeutic agents. Transfersomes are novel vesicular systems that are several times more elastic than other vesicular systems. These are composed of edge activator, phospholipids, ethanol, and sodium cholate and are applied in a non-occlusive manner. Areas covered: This article covers information such as merits/demerits of transfersomes, regulatory aspects of materials used in preparation, different methods of preparation, mechanism of action, review of clinical investigations performed, marketed preparations available, research reports, and patent reports related to transfersomes. Expert opinion: Research over the past few years has provided a better understanding of transfersomal permeation of therapeutic agents across stratum corneum barrier. Transfersomes provides an essential feature of their application to variety of compositions in order to optimize the permeability of a range of therapeutic molecules. This is evidenced by the fact that there are several Transfersome products being processed in advanced clinical trials. It is noteworthy that a number of Transfersome products for dermal and transdermal delivery will gain a global market success in near future.

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“…Nanotechonology, whose importance is presently undisputed [1,2] represents the avenue and the frontier of Biotechnology and Biomedical Engineering. Among many of the possible new solutions, the ones regarding disadvantages of current biomedical devices that increase transport across the skin, such as microneedles [2,3], are of particular interest in transdermal applications.…”

Section: Introductionmentioning

confidence: 99%

Dermic diffusion and stratum corneum: A state of the art review of mathematical models

Couto

Fernandes

Cordeiro

et al. 2014

Journal of Controlled Release

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A B S T R A C TTransdermal biotechnologies are an ever increasing field of interest, due to the medical and pharmaceutical applications that they underlie. There are several mathematical models at use that permit a more inclusive vision of pure experimental data and even allow practical extrapolation for new dermal diffusion methodologies. However, they grasp a complex variety of theories and assumptions that allocate their use for specific situations. Models based on Fick's First Law found better use in contexts where scaled particle theory Models would be extensive in time-span but the reciprocal is also true, as context of transdermal diffusion of particular active compounds changes. This article reviews extensively the various theoretical methodologies for studying dermic diffusion in the rate limiting dermic barrier, the stratum corneum, and systematizes its characteristics, their proper context of application, advantages and limitations, as well as future perspectives.

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Nanotechnology and the transdermal routeA state of the art review and critical appraisal

Cited by 504 publications

References 268 publications

Development of ionic-complex-based nanostructured lipid carriers to improve the pharmacokinetic profiles of breviscapine

Development of ionic-complex-based nanostructured lipid carriers to improve the pharmacokinetic profiles of breviscapine

Transfersomes as versatile and flexible nano-vesicular carriers in skin cancer therapy: the state of the art

Dermic diffusion and stratum corneum: A state of the art review of mathematical models

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