Nanotechnology: A Promising Tool Towards Wound Healing

Alberti, Thaís; Coelho, Daniela; Voytena, Ana Paula Lorenzen; Pitz, Heloísa da Silva; Prá, Manuel de; Mazzarino, Letícia; Kuhnen, Shirley; Ribeiro‐do‐Valle, Rosa Maria; Maraschin, Marcelo; Veleirinho, Beatriz

doi:10.2174/1381612823666170503152550

Cited by 55 publications

(52 citation statements)

References 115 publications

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“…Versatility is one of the most important advantages of the electrospinning technique. Different morphologies can be achieved by varying configuration and parameters of the electrospinning process [7]. Taken together, these characteristics show applicability in many different areas, such as high performance, intelligent textiles, biosensors, scaffolds for tissue engineering, and drug delivery systems [5].…”

Section: Electrospinning Nanofibersmentioning

confidence: 99%

“…Furthermore, PVA has been used as a copolymer to enhance electrospinnability and mechanical properties of biopolymers like chitosan [31,32]. The biocompatibility of PVA allows its application in biomaterials for dermal and orthopedic tissue engineering [7,31]. PVA was associated with chitosan blends in which the increase of chitosan derivative ratio resulted in smaller fiber diameters and higher antibacterial effect, both advantageous properties against skin infection [23].…”

Section: Polyvinyl Alcohol (Pva)mentioning

confidence: 99%

“…Acute wound healing is a well-organized process, following four phases known as hemostasis, inflammation, proliferation, and remodeling (Figure 2). Immediately after microvascular injury and extravasation of blood and its components into the wound, a complex process involving coordinated interaction between diverse immunological and biological systems begins [7,10]. Along with hemostatic events, the coagulation cascade is activated through extrinsic and intrinsic pathways, leading to platelet aggregation and clot formation in order to limit blood loss ( Figure 2B) [29].…”

Section: Applications Of Nanofiber In Skin Wound Healingmentioning

confidence: 99%

“…During remodeling, the cellularity of the granulation tissue gradually decreases. Additionally, a series of rearrangements of ECM take place (Figure 2E) [7]. Unlike acute wounds, chronic wounds are a result of gradual tissue degradation by chemical and biological agents like proteolytic enzymes derived from neutrophils.…”

Section: Applications Of Nanofiber In Skin Wound Healingmentioning

confidence: 99%

“…Throughout all stages, the nanofiber composite interacts with the tissue, releasing drugs that will facilitate the healing process. This figure is an adaptation from Alberti and coworkers [7].…”

Section: Wound Dressing Nanofiber Layers Of Epidermis (Ep) Dermis (mentioning

confidence: 99%

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Electrospinning Technology: Designing Nanofibers toward Wound Healing Application

Coelho¹,

Veleirinho²,

Alberti³

et al. 2020

Nanomaterials - Toxicity, Human Health and Environment

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Electrospinning is a widely used technology to obtain nanofibers. Electrospun systems have been especially investigated for wound dressings in skin regeneration given the similarity of structures with the extracellular matrix. Several efforts have been made to combine distinct design strategies, such as utilizing synthetic and/or natural materials, modifying fiber orientation, and incorporating substances, e.g., drugs, peptides, growth factors or other biomolecules, to develop an optimized electrospun wound dressing. This chapter reviews the current advances in electrospinning strategies for skin regeneration.

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Section: Electrospinning Nanofibersmentioning

confidence: 99%

Section: Polyvinyl Alcohol (Pva)mentioning

confidence: 99%

Section: Applications Of Nanofiber In Skin Wound Healingmentioning

confidence: 99%

Section: Applications Of Nanofiber In Skin Wound Healingmentioning

confidence: 99%

Section: Wound Dressing Nanofiber Layers Of Epidermis (Ep) Dermis (mentioning

confidence: 99%

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Electrospinning Technology: Designing Nanofibers toward Wound Healing Application

Coelho¹,

Veleirinho²,

Alberti³

et al. 2020

Nanomaterials - Toxicity, Human Health and Environment

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Preparation and Investigation of Thermally Annealed Zein–Propolis Electrospun Nanofibers for Biomedical Applications

Hochheim

Sampaio

Cruz

et al. 2023

Macromolecular Bioscience

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Zein, a corn‐derived protein, has a variety of applications ranging from drug delivery to tissue engineering and wound healing. This work aims to develop a biocompatible scaffold for dermal applications based on thermally annealed electrospun propolis‐loaded zein nanofibers. Pristine fibers' biocompatibility is determined in vitro. Next, propolis from Melipona quadrifasciata is added to the fibers at different concentrations (5% to 25%), and the scaffolds are studied. The physicochemical properties of zein/propolis precursor dispersions are evaluated and the results are correlated to the fibers' properties. Due to zein's and propolis' very favorable interactions, which are responsible for the increase in the dispersions surface tension, nanometric size ribbon‐like fibers ranging from 420 to 575 nm are obtained. The fiber's hydrophobicity is not dependent on propolis concentration and increases with the annealing procedure. Propolis inhibitory concentration (IC50) is determined as 61.78 µg mL−1. When loaded into fibers, propolis is gradually delivered to cells as Balb/3T3 fibroblasts and are able to adhere, grow, and interact with pristine and propolis‐loaded fibers, and cytotoxicity is not observed. Therefore, the zein–propolis nanofibers are considered biocompatible and safe. The results are promising and provide prospects for the development of wound‐healing nanofiber patches—one of propolis' main applications.

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Nanomaterials in wound healing: From material sciences to wound healing applications

et al. 2020

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An increasing number of innovative therapies have emerged in the field of wound healing. Nanostructured systems have been used to improve wound healing at different stages. The drug itself may be formulated at a nanoscale such that it can function as its own "carrier" or nanomaterials may be used as drug delivery vehicles. The present work covers the latest advancements on innovative nano-based organic and inorganic materials. These novel drug delivery systems possess high stability, large surface area and tunable compositions and have demonstrated their wound-healing properties using in vitro and in vivo models. Key areas in the development of new systems for wound care are the assessment of biological compatibility, the evaluation of anti-microbial activity and the in vivo efficacy assessment using full-thickness skin models. Due to the multifactorial nature of chronic wound occurrence robust models should support the investigation of new materials in order to elucidate mechanisms involved in the sequence of physiologic processes that take place at wound healing. Although several nanoparticles have been successfully tested both in vitro and in vivo, researchers are still investigating the approaches to implementing large scale production of nanotechnological platforms to wound healing treatments.

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Nanotechnology: A Promising Tool Towards Wound Healing

Cited by 55 publications

References 115 publications

Electrospinning Technology: Designing Nanofibers toward Wound Healing Application

Electrospinning Technology: Designing Nanofibers toward Wound Healing Application

Preparation and Investigation of Thermally Annealed Zein–Propolis Electrospun Nanofibers for Biomedical Applications

Nanomaterials in wound healing: From material sciences to wound healing applications

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