Nanotechnologies for the Bioelectronic Interface

Avants, Benjamin W.; Park, Hongkun; Robinson, Jacob T.

doi:10.1002/9783527801312.ch6

“…In recent years there has been an explosion of work focused on the development and use of nanotechnologies aimed at interacting and interfacing with the brain and central nervous system generally ( Silva, 2006 , 2007a , b , 2008 , 2010 ; Kotov et al, 2009 ; De Vittorio et al, 2014 ; Saxena et al, 2015 ; Badry and Mattar, 2017 ; Scaini and Ballerini, 2017 ; Rosenthal, 2018 ), and in the context of BMI and neural prosthesis in particular ( Webster et al, 2003 ; Lovat et al, 2005 ; Fabbro et al, 2012 ; Nicolas-Alonso and Gomez-Gil, 2012 ; Seo et al, 2013 ; Avants et al, 2016 ; Ha et al, 2016 ; Scaini and Ballerini, 2017 ). Considerable recent effort has focused on nanoscale neurotechnologies aimed at recording from and stimulating from the brain at high densities.…”

Section: Beyond the Current State Of The Art: Machine Learning Enablementioning

confidence: 99%

A New Frontier: The Convergence of Nanotechnology, Brain Machine Interfaces, and Artificial Intelligence

Silva

¹

2018

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A confluence of technological capabilities is creating an opportunity for machine learning and artificial intelligence (AI) to enable “smart” nanoengineered brain machine interfaces (BMI). This new generation of technologies will be able to communicate with the brain in ways that support contextual learning and adaptation to changing functional requirements. This applies to both invasive technologies aimed at restoring neurological function, as in the case of neural prosthesis, as well as non-invasive technologies enabled by signals such as electroencephalograph (EEG). Advances in computation, hardware, and algorithms that learn and adapt in a contextually dependent way will be able to leverage the capabilities that nanoengineering offers the design and functionality of BMI. We explore the enabling capabilities that these devices may exhibit, why they matter, and the state of the technologies necessary to build them. We also discuss a number of open technical challenges and problems that will need to be solved in order to achieve this.

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“…[20][21][22][23][24][25] Despite implementation of these platforms in a variety of advanced cellular applications-such as in vivo and ex vivo gene editing, recording cellular action potential, and immunomodulation-the development of this burgeoning eld is hindered by a lack of tools allowing for direct, rapid, and dynamic visualization of living cells interacting with these nanostructures. [26][27][28][29][30][31][32] Recent advances in combinatorial nanofabrication routes now offer precise control over SiNWs growth, topological parameters, and array architecture, overcoming the limitations of conventional fabrication that have restricted cell-NW studies. [33][34][35] Combining colloidal lithography techniques, such as convective assembly and self-assembly at liquid-liquid interfaces, with either metal-assisted chemical etching (MACE) or deep reactive ion etching (DRIE), enables controlled VA-SiNWs growth.…”

Section: Introductionmentioning

confidence: 99%

Optically Transparent Vertical Silicon Nanowire Arrays for Live-Cell Imaging

Elnathan

¹

,

Holle

²

,

Young

³

et al. 2021

Preprint

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Programmable nano-bio interfaces driven by tuneable vertically configured nanostructures have recently emerged as a powerful tool for cellular manipulations and interrogations. Such interfaces have strong potential for ground-breaking advances, particularly in cellular nanobiotechnology and mechanobiology. However, the opaque nature of many nanostructured surfaces makes non-destructive, live-cell characterization of cellular behavior on vertically aligned nanostructures challenging to observe. Here, a new nanofabrication route is proposed that enables harvesting of vertically aligned silicon (Si) nanowires and their subsequent transfer onto an optically transparent substrate, with high efficiency and without artefacts. We demonstrate the potential of this route for efficient live-cell phase contrast imaging and subsequent characterization of cells growing on vertically aligned Si nanowires. This approach provides the first opportunity to understand dynamic cellular responses to a cell-nanowire interface, and thus has the potential to inform the design of future nanoscale cellular manipulation technologies.

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“…[18][19][20][21][22][23] Despite implementation of these platforms in a variety of advanced cellular applications-such as in vivo and ex vivo gene editing, recording cellular action potential, and immunomodulation-the development of this burgeoning eld is hindered by a lack of tools allowing for direct, rapid, and dynamic visualization of living cells interacting with these nanostructures. [24][25][26][27][28][29][30] Recent advances in combinatorial nanofabrication routes now offer precise control over SiNWs growth, topological parameters, and array architecture, overcoming the limitations of conventional fabrication that have restricted cell-NW studies. [31][32][33] Combining colloidal lithography techniques, such as convective assembly and self-assembly at liquid-liquid interfaces, with either metal-assisted chemical etching (MACE) or deep reactive ion etching (DRIE), enables controlled VA-SiNWs growth.…”

Section: Introductionmentioning

confidence: 99%

Optically Transparent Vertical Silicon Nanowire Arrays for Live-Cell Imaging

Elnathan

¹

,

Holle

²

,

Young

³

et al. 2021

Preprint

0

View full text Add to dashboard Cite

Programmable nano-bio interfaces driven by tuneable vertically configured nanostructures have recently emerged as a powerful tool for cellular manipulations and interrogations. Such interfaces have strong potential for ground-breaking advances, particularly in cellular nanobiotechnology and mechanobiology. However, the opaque nature of many nanostructured surfaces makes non-destructive, live-cell characterization of cellular behavior on vertically aligned nanostructures challenging to observe. Here, a new nanofabrication route is proposed that enables harvesting of vertically aligned silicon (Si) nanowires and their subsequent transfer onto an optically transparent substrate, with high efficiency and without artefacts. We demonstrate the potential of this route for efficient live-cell phase contrast imaging and subsequent characterization of cells growing on vertically aligned Si nanowires. This approach provides the first opportunity to understand dynamic cellular responses to a cell-nanowire interface, and thus has the potential to inform the design of future nanoscale cellular manipulation technologies.

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Nanotechnologies for the Bioelectronic Interface

Cited by 4 publications

References 66 publications

A New Frontier: The Convergence of Nanotechnology, Brain Machine Interfaces, and Artificial Intelligence

A New Frontier: The Convergence of Nanotechnology, Brain Machine Interfaces, and Artificial Intelligence

Optically Transparent Vertical Silicon Nanowire Arrays for Live-Cell Imaging

Optically Transparent Vertical Silicon Nanowire Arrays for Live-Cell Imaging

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