Nanotechnologies for Medical Devices: Potentialities and Risks

Pallotta, Arnaud; Clarot, Igor; Sobocinski, Jonathan; Fattal, Elias; Boudier, Ariane

doi:10.1021/acsabm.8b00612

Cited by 23 publications

(12 citation statements)

References 101 publications

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“…This raises several questions in terms of target organs, collection time, gold dissemination, LLOQ, etc. Compared to other studies, the quantity of injected AuNPs was less important, but may be more representative of a real exposition to AuNPs [33].…”

Section: Application: In Vivo Gold Quantification From Aunp Distribution After IV Injectionmentioning

confidence: 83%

Monitoring of Gold Biodistribution from Nanoparticles Using a HPLC-Visible Method

et al. 2021

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There is intensive research using gold nanoparticles for biomedical purposes, which have many advantages such as ease of synthesis and high reactivity. Their possible small size (<10 nm) can lead to the crossing of biological membranes and then to problematic dissemination and storage in organs that must be controlled and evaluated. In this work, a simple isocratic HPLC method was developed and validated to quantify the gold coming from nanoparticles in different biological samples. After a first carbonization step at 900 °C, the nanoparticles were oxidized by dibroma under acidic conditions, leading to tetrachloroaurate ions that could form ion pairs when adding rhodamine B. Finally, ion pairs were extracted and rhodamine B was evaluated to quantify the corresponding gold concentration by reversed-phase HPLC with visible detection. The method was validated for different organs (liver, spleen, lungs, kidneys, or brain) and fluids (plasma and urine) from rats and mice. Lastly, the developed method was used to evaluate the content of gold in organs and fluids after intravenous (IV) injection of nanoparticles.

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Section: Application: In Vivo Gold Quantification From Aunp Distribution After IV Injectionmentioning

confidence: 83%

Monitoring of Gold Biodistribution from Nanoparticles Using a HPLC-Visible Method

et al. 2021

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“…Bioengineered nano materials have witnessed a dramatic growth within the previous couple of years to satisfy the growing demand for novel technologies in both the scientific and industrial sectors [33][34][35][36] .Medical implants though successful in treating disease and injury, it suffers from various complications like infections and inflammatory reactions instigated by bacteria colonizing and biofilm formation. This can be minimized either by Impregnating or coating with antibacterial agent which is one of the strategy and silver Nanoparticles has gained enormous attention [37][38] . Silver nanoparticle is one of the most vital and fascinating metallic nano materials in biomedical application.…”

Section: Discussionmentioning

confidence: 99%

Fabrication of Silver Nano composite on Copper Metal- A Potential Strategy to Alleviate Pelvic Inflammatory Disease

Prabasheela¹,

Sakithya²

2020

Int J Pharma Bio Sci

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Nano silver particle (NSPs), is one of the most attractive nano materials, and has been widely used in a range of biomedical applications, including diagnosis, treatment, drug delivery, medical device coating, and for personal health care. Silver nanoparticles can be synthesized by various methods but citrate reduced and stabilized particles gain an advantage over other methods because of its morphology, stable nature, cost effective and easy scale-up nature. In the present study, the silver nanoparticle was synthesized by reducing silver salt with sodium citrate that showed the characteristic peak at 410 nm by means of UV-Visible spectroscopy. Antibacterial activity was performed against S.aureus and P.aeruginosa, and S.aureusand was found to be more susceptible. Characterized colloidal silver nanoparticles were used for the coating process. Coating on copper plate was achieved by Dip method, and characterized using SEM, EDAX and FTIR. Resulting EDAX and SEM images showed the morphology of the coated surface with their elemental composition. FTIR interferogram showed the characteristic functional groups at 1290.09 cm -1 and 1483.68cm -1 responsible for the reduction of silver salt into silver nanoparticles. Antimicrobial activity was performed for the coated metal against the Trichomonasvaginalis, a sexual transmitted pathogen that attribute to pelvic inflammatory disease (PID).The inhibition diameter is of about 31mm, thereby considering the fabricated nano composite to be effective against the disease causing microbial species. Invitro cytotoxicity studies in the Vero cell line show 81% viability with no significant morphological alterations. Hence, the fabricated nano composite could be a future benchmark for implant functionalization.

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“…Medical devices refer to instruments, tools, machines, devices, in vitro reagents, implants, or other similar/related items, including accessories recognized by or components in the official national formulary, United States Pharmacopoeia (USP), or any supplement thereof. [31,32] These devices are intended to be used in the medical field to treat, alleviate or diagnose diseases, prevent diseases of humans or other animals, and affect the structure and function of humans or other animals. [33,34] However, these devices do not realize any of the main intended purposes by chemical action and metabolism in humans or other animals.…”

Section: Required Properties Of E-skin For Medical Devicesmentioning

confidence: 99%

Wearable, Implantable, and Interventional Medical Devices Based on Smart Electronic Skins

Wang

Jiang

Shen

2021

Adv Materials Technologies

105

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Recent advances in soft, flexible, and stretchable sensors have offered a good opportunity to design various types of wearable flexible medical devices for achievement of continuous health monitoring, preventive medicine and robot feedback and control. The integration of biofunctionability with electronic skin is undoubtedly an attractive prospect in the sense that the successful medical device requires good biocompatibility, sensing capability, and high degrees of mechanical flexibility. This work summarizes the last developments in electronic skin for next‐generation medical devices that can simultaneously detect a variety of physiological information of the human body. The key properties of e‐skin that must be realized for their versatile use in medical applications are discussed in detail. Next, the paper outlines the overall applications of these sensors in wearable medicine, implantable medicine, and interventional medicine, and emphasizes how these devices monitor human health status and may be expected to replace traditional clinical tools. Finally, the challenges and future research opportunities in the field of wearable health monitoring are proposed.

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Nanotechnologies for Medical Devices: Potentialities and Risks

Cited by 23 publications

References 101 publications

Monitoring of Gold Biodistribution from Nanoparticles Using a HPLC-Visible Method

Monitoring of Gold Biodistribution from Nanoparticles Using a HPLC-Visible Method

Fabrication of Silver Nano composite on Copper Metal- A Potential Strategy to Alleviate Pelvic Inflammatory Disease

Wearable, Implantable, and Interventional Medical Devices Based on Smart Electronic Skins

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