Nanotechnological Approaches for Enhancing the Oral Bioavailability of Curcumin

An amplified sonodynamic therapy by a nanohybrid of titanium dioxide-gold-polyethylene glycol-curcumin: HeLa cancer cells treatment in 2D monolayer and 3D spheroid models

“…The popularity of natural medicines has been increased due to their low toxicity, lack of adverse effects and affordability. As a naturally occurring compound, curcumin exhibits a wide range of anti-oxidant, anti-inflammatory, anti-carcinogenic, anti-diabetic, anti-parasitic, anti-bacterial, anti-fungal, anti-Alzheimer’s, immunity modulatory, wound healing and angiogenesis inhibitory properties [38] , [39] , [40] . In addition to its unique properties, curcumin also reduces tumor burden, induces death in cancer cells, and prevents cancer cells from multiplying [38] , [39] .…”

“…Regardless of its potential therapeutic benefits, the lack of bioavailability, poor solubility, low absorption, rapid metabolism, high excretion rate, limited tissue distribution, and poor stability of the curcumin present significant challenges [45] . Nanoformulations of curcumin such as encapsulating in or binding with nanocarriers, or conjugating with PEG can solve the curcumin insolubility, increase its circulation time, and may also mitigate its disadvantages [40] , [46] . Encapsulating or binding with metal oxides such as TiO 2 , ZnO, Fe 3 O 4 , CeO 2 and CuO protects curcumin from hydrolysis and phagocytosis, leading to its improved aqueous contact, blood circulation, stability, and bioavailability [47] .…”

Green Synthesis and Characterization of Gold Nanoparticles using Ethanolic Turmeric Crude Extract At Neutral Ph

“…Inspite of therapeutic potential of turmeric, its water solubility and bioavailability is low. Different methods have been developed to increase the bioavailability of turmeric [28], one of them being the turmeric-mediated nanoparticle synthesis. The conjugation of turmeric and metal ions in an aqueous medium to synthesize nanoparticles can increase its stability, activity, bioavailability and half-life [29][30].…”