Nanotech approaches to drug delivery and imaging

Sahoo, Sanjeeb K.; Labhasetwar, Vinod

doi:10.1016/s1359-6446(03)02903-9

Cited by 984 publications

(537 citation statements)

References 78 publications

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“…AFM ability to explore samples under variety of environmental conditions, without the need to perform any sample preparation such as staining, labeling, fixation, etc. including biological specimens in an aqueous/physiological environment, or in air at different temperatures, or under controlled humidity, make it a very versatile characterization technique, with lateral and vertical resolution (Sahoo and Labhasetwar 2003;Prater et al 1991;Khosravi-Darani et al 2007;Colas et al 2007). AFM is being widely used to study the size and adsorption behavior of vesicles on solid substrates (Mozafari 2005;Colas et al 2007).…”

Section: Application Of Ccd For Production Flavourzyme-loaded Liposomementioning

confidence: 99%

The encapsulation of flavourzyme in nanoliposome by heating method

et al. 2013

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The main objective of this study was to use heating method (HM) to prepare liposome without employing any chemical solvent or detergent. Plackett-Burman design (PBD) was applied for the screening of significant process variables including the lecithin proportion, the cholesterol/ lecithin ratio, the pH of solution for liposome preparation, the enzyme/lecithin ratio, the stirring time, the process temperature, the speed of stirrer, the ratio of stirrer to the tank diameter, the application of homogenization, the method of adding enzyme and centrifugation conditions on the encapsulation efficiency (EE %) of liposome and the activity of liposomal Flavourzyme (LAPU −1 ) (P<0.05). Then, the response surface methodology based on the central composite design (CCD) was applied for the evaluation of the impacts of the significant mentioned variables on the EE (%) and the activity of the liposomal Flavourzyme. The results indicated that the lecithin proportion and the stirring time were the major influential variables for both responses. The most suitable formulation of the Flavourzyme-loaded liposome is 4.5 % lecithin, 45°C temperature, 5 % Flavourzyme/lecithin ratio, 30 min stirring time and medium pH of 6. Under suitable operating conditions, the EE of liposome and the activity of the liposomal Flavourzyme were achieved as 26.5 % and 9.96 LAPU ml −1 , respectively. AFM technique and size distribution clearly showed the diameter of 189 nm for the spherical shape of the Flavourzyme-loaded nanoliposome.

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Section: Application Of Ccd For Production Flavourzyme-loaded Liposomementioning

confidence: 99%

The encapsulation of flavourzyme in nanoliposome by heating method

et al. 2013

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“…Nanotechnology can be defined as the science involved in the design, synthesis, characterisation, and application of materials and devices whose smallest functional organization in at least one dimension is on the nanometer scale 1,2 . It is an emerging field that has contributed to the development of novel diagnostic and therapeutic agents, with the advantage of enhancing drug accumulation at the site of interest and avoiding side effects common to small molecule drugs 3 .…”

Section: Introductionmentioning

confidence: 99%

Nanotechnology in Dentistry

Arruda¹,

Oliveira²,

Paula³

et al. 2017

Arch Health Invest

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Introduction: Nanotechnology is a rapidly expanding field that encompasses the development, manipulation, and application of structures on the nanometer scale. Applications of nanotechnology to dentistry are particularly promising and comprise materials and devices designed to achieve maximal therapeutic efficacy with minimal side effects. Objective: This review discusses the advantages of nanotechnology and the different types of nanostructures used in dentistry. Material and Method: In this study, online databases: pubmed, medline and scielo were searched to analyse the current understanding of the potential of nanotechnology in dentistry, including the restoration of tooth structure with nanocomposites and the development of nanoparticles for dentin remineralisation, drug delivery, disease diagnostics, oral analgesia, oral hygiene maintenance, local anaesthesia, tooth desensitisation, and bone tissue repair. Results: The study demonstrated a wide range of nanotechnological strategies in different dentistry areas and suggests that nanotechnology-based delivery systems may be very useful to improve treatment, prevention and repair in dentistry in the future. Conclusion: There is little or no clinical experience for the nanotechnology-based drug delivery systems cited herein. Safety assessments and clinical trials are the next step in their development.

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“…In this field, nano-based drug delivery system specifically nanoparticles have developed a great modification that provides new opportunities to move over hindrances and flaws of conventional drug delivery methods like enhance solubility of drugs, diminish drug toxicity, beshields drugs from deterioration, ineffective and benign delivery of drugs to specific target sites in the body, etc. [12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%