Nanosystems for Skin Delivery: From Drugs to Cosmetics

Antunes, Ana F.; Pereira, Paula; Reis, Claudia; Rijo, Patrícia; Reis, Catarina Pinto

doi:10.2174/1389200218666170306103101

Cited by 24 publications

(7 citation statements)

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“…Because of their small size, nanoparticles (NPs) are used not only in cosmetics, microelectronics and medicinal products , but also in food. In food and food-related products, NPs could be used for, but not limited to, antimicroorganisms, color development, and nutrient supplement. , As such, oral exposure of human beings to NPs via food and food-related products is likely increasing, and there is a need to assess the toxicity of NPs to cells lining the gastrointestinal tract .…”

Section: Introductionmentioning

confidence: 99%

Chemical Structures of Polyphenols That Critically Influence the Toxicity of ZnO Nanoparticles

Cao

Liu

et al. 2018

J. Agric. Food Chem.

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Recent studies suggested that phytochemicals as natural antioxidants in food could alleviate nanoparticle (NP) toxicity. This study investigated the combined toxicity of ZnO NPs and a panel of polyphenols. Surprisingly, polyphenols with both high and almost no radical scavenging activities could elicit cytoprotective effects against NP exposure in Caco-2 cells, which were primarily influenced by the positions of the hydroxyl group. Polyphenols with different chemical structures variously influenced the hydrodynamic size, zeta potential, and solubility of ZnO NPs as well as NP-induced intracellular superoxide and Zn ions, which could all contribute to the combined effects. Responses of human endothelial cells appeared to be different from the responses of Caco-2 cells, which may indicate cell-type dependent responses to combined exposure of NPs and phytochemicals. In conclusion, the data from this study suggested a pivotal role of chemical structures of phytochemicals in determining their capacity to affect ZnO NP toxicity.

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Section: Introductionmentioning

confidence: 99%

Chemical Structures of Polyphenols That Critically Influence the Toxicity of ZnO Nanoparticles

Cao

Liu

et al. 2018

J. Agric. Food Chem.

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“…The potential for NMs to translocate to distal organs following a variety of exposure routes is a reality, with the liver shown to accumulate a large proportion of the total or translocated dose (Antunes et al 2017;Argueta-Figueroa et al 2017;Lim et al 2017). This clearly highlights the necessity for a thorough investigation of the impact of NM exposure to normal liver function.…”

Section: Discussionmentioning

confidence: 99%

A review of hepatic nanotoxicology – summation of recent findings and considerations for the next generation of study designs

Kermanizadeh

Powell

Stone

2020

Journal of Toxicology and Environmental Health, Part B

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The liver is one of the most important multi-functional organs in the human body. Amongst various crucial functions, it is the main detoxification center and predominantly implicated in the clearance of xenobiotics potentially including particulates that reach this organ. It is now well established that a significant quantity of injected, ingested or inhaled nanomaterials (NMs) translocate from primary exposure sites and accumulate in liver. This review aimed to summarize and discuss the progress made in the field of hepatic nanotoxicology, and crucially highlight knowledge gaps that still exist. Key considerations include The review offers a number of important suggestions for the future of hepatic nanotoxicology study design. This is of great significance as its findings are highly relevant due to the development of more advanced in vitro, and in silico models aiming to improve physiologically relevant toxicological testing strategies and bridging the gap between in vitro and in vivo experimentation.

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“…As cosmeceutical agents, liposomes have been employed in various dermatological conditions like acne vulgaris and hyperpigmentation formulated with clindamycin hydrochloride (clindamycin HCl) and 4-n-butylresorcinol (BR), respectively (Rahimpour Y and Hamishehkar 2012). So the lipid based particulate systems were introduced first in the early 90s and have greatly evolved with time form the preliminary liposomal formulations to the recent more advanced nanosystems like solid lipid nanoparticles and nanolipid carriers, where the limitations of liposomes like burst release of active cosmeceutical, solubility limitations, high production costs, and probable oxidation and hydrolytic reactions of phospholipids have greatly been overcome (Antunes et al 2017).…”

Section: Liposomesmentioning

confidence: 99%

Lipid-based formulations in cosmeceuticals and biopharmaceuticals

Ahmad

Ahsan

2020

biomed dermatol

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The fatty acids containing plant oils have been used as components of cosmetic formulations, and the best cosmetic function has been established for unsaturated fatty acids present in triglycerides. Many oils, fats, waxes, and phospholipids are employed as excipients in cosmetics and personal care products. Antioxidants such as carotenoids, retinoids, and tocopherols are used for their antioxidant properties because of their importance in therapeutic care. For skin care, the most important are oils with high contents of linoleic and α-linolenic acid which reduce the formation of eczemas or atopic dermatitis. These essential fatty acids incorporate into the cell membranes and regenerate the damaged lipid barrier of epidermis and restrict water loss. The unsaturated fatty acids show prominent healing effects on skin inflammation and are used in various cosmetic products. Mineral oils and waxes are also used in several products due to their property of skin tolerance, protection, cleansing, and viscosity. As cosmeceutical formulation, the nanoformulations are effective against irritated and inflamed skin and effective for therapy of atopic dermatitis and psoriasis. The lipid nanoparticles offer advantages of chemical stability and good skin compatibility that can be used for protection against radiation and aging.

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Nanosystems for Skin Delivery: From Drugs to Cosmetics

Cited by 24 publications

References 0 publications

Chemical Structures of Polyphenols That Critically Influence the Toxicity of ZnO Nanoparticles

Chemical Structures of Polyphenols That Critically Influence the Toxicity of ZnO Nanoparticles

A review of hepatic nanotoxicology – summation of recent findings and considerations for the next generation of study designs

Lipid-based formulations in cosmeceuticals and biopharmaceuticals

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