Nanosuspensions of poorly soluble drugs: Preparation and development by wet milling

Heat induced evaporative antisolvent nanoprecipitation (HIEAN) of itraconazole

“…The DSC measurements were performed using a Mettler Toledo DSC 821e (Greifensee, Switzerland), under nitrogen purge. A temperature range of 25-200 °C was applied with a heating rate of 10 180 °C/min (Liu et al 2011). For the spray dried material a 5 °C/min heating rate was also used.…”

“…Liu et al (2011) reported that PEG is not suitable for the 305 production of ITR nanosuspensions using milling due to the absence of any hydrophobic groups which are required for the adsorption of the stabiliser on hydrophobic drugs such as ITR.…”

Development of a Nanocrystalline Paclitaxel Formulation for Hipec Treatment

“…Previous research already described that nanoparticles (>50 nm) can adhere to mucosa, thus prolonging the contact time of the drug and enhancing its absorption (11). Prolonged retention of PTX in the peritoneal cavity (in combination with enhanced PTX penetration) can offer a therapeutic advantage as tumor cells are exposed for a longer time to higher local drug levels.…”

“…The mechanical grinding by milling pearls in water is used to obtain drug/stabilizer suspensions (11) with a particle size lower than 1µm. In this study, the wet milling technique is applied to obtain a paclitaxel nanosuspension stabilized with a surfactant (polyethylene oxide-polypropylene oxide block copolymers, Pluronic F68 ® and Pluronic F127 ® ).…”

Nanoencapsulação do fármaco miltefosina em micelas poliméricas de poli(óxido de etileno)-poli(óxido de propileno)

“…A necessidade de um estabilizador durante a liofilização de nanopartículas é importante para se obter uma amostra que possa ser facilmente reconstituível (HOLZER et al, 1999). Estudos apontam que os polímeros pluronics F68, F127 e polisorbato 80 têm se mostrado eficazes na estabilização da indometacina (LIU et al, 2015;LIU et al, 2011;TUOMELA et al, 2015). Portanto, no caso de micelas poliméricas dormadas pela agregação de pluronic F127 a própria formulção poderia exercer efeito crioprotetor.…”