Nanosuspension Technology: A Innovative Slant for Drug Delivery System and Permeability Enhancer for Poorly Water Soluble Drugs

Abstract

Nanosuspension contains submicron colloidal dispersion of pharmaceutical active ingredient particles in a liquid phase stabilized by surfactants. The poor water solubility of drugs is major problem for drug formulation. The reduction of drug particles into the sub-micron range leads to a significant increase in the dissolution rate, bioavailability as well as improve stability. Nanosuspension consists of the pure poorly water-soluble drug without any matrix material suspended in dispersion. Nanosuspension many attempts have been made to deliver poorly water soluble drugs as a nanosuspension prepared by adopting various methods. Techniques such as media milling and high pressure homogenization have been used commercially for producing nanosuspension. Recently, engineering of nanosuspension employs emulsions and microemulsion as templates. The unique features of nanosuspension have enabled their use in various dosage forms, including specialized delivery systems such as mucoadhesive hydrogels, parenteral, peroral, ocular and pulmonary routes.

Strengths, weaknesses, opportunities and challenges for long acting injectable therapies: Insights for applications in HIV therapy

“…However, the development of mechanical attrition processes [64] (for example nanomilling technologies and high pressure homogenisation) and non-attrition nanoparticle fabrication (for example emulsion-templated freeze drying) has allowed access to nano-scale solid drug particles (< 1 μm) [65-68]. The rilpivirine LA and cabotegravir LA options [6, 7] that are in extended clinical trials (including evaluation of simultaneous combination in LATTE 2) are based upon this technology.…”

Solubility enhancement (Solid Dispersions) novel boon to increase bioavailability

“…Nonvolatile solvent present in the liquisolid system facilitates wetting of drug particles by decreasing interfacial tension between dissolution medium and tablet surface. Shah [26][27][28][29][30][31][32][33][34][35][36][37][38][39][40] Classification based on type of liquid medication contain there in:…”

“…Limitation regarding this method is at high temperature many drug may get degraded. [30][31][32][33][34][35][36][37][38] : HME can be simply defined as the process of forming a new material (the extrude) by forcing it through an orifice or die under controlled conditions, such as temperature, mixing, feed-rate and pressure. HME differs from simple extrusion in that, polymer, drug and excipients blends are mixed thoroughly in the molten state in this process, needing no solvents for granulation.…”

Novel Multiparticulate Drug Delivery System of Carvedilol as Antihypertensive Drug

“…Various formulation parameters that play a crucial role in the successful formulation of drugs are aqueous solubility, stability at ambient temperature and humidity, photo stability, compatibility with solvent and excipients 9 .…”