Nanosuspension: An Overview

Aher, Smita S.; Malsane, Sagar T.; Saudagar, R. B.

doi:10.22159/ijcpr.2017.v9i3.19584

Cited by 19 publications

(16 citation statements)

References 10 publications

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“…These limitations can be overcome with nanostructured lipid carriers (NLCs). NLCs improve therapeutic efficiency of the drug by prolonging the drug retention time on the buccal mucosa tissue [10], and by providing controlled drug release near the disease area.…”

Section: Introductionmentioning

confidence: 99%

Development and Characterization of Piper Retrofractum Extract Loaded Mucoadhesive Nanostructured Lipid Carriers for Topical Oral Drug Delivery

Srichaivatana

Ounaroon

Tiyaboonchai

2017

Int J Pharm Pharm Sci

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Objective: To develop and characterize Piper retrofractum extract loaded nanostructured lipid carriers (PRE loaded NLCs) for topical oral cavity administration to enhance bioavailability and stability of piperine.Methods: PRE loaded NLCs were prepared with a hot high-pressure homogenization technique followed by coating the particle surface with mucoadhesive polymers; polyethene glycol 400 (PEG) and polyvinyl alcohol (PVA). The physicochemical properties in terms of particle size, polydispersity index, zeta potential, drug entrapment efficiency, in vitro drug release profile and antimicrobial activities were examined. In vitro, mucoadhesion studies were assessed by the wash-off test. The physicochemical stabilities of mouth spray containing PRE loaded NLCs were investigated by kept at room temperature and 4 °C for 6 mo. Results:The PRE loaded NLCs showed spherical shape with a mean particle size of ~100-120 nm and zeta potential of ~-24 mV. Up to 90% drug entrapment efficiency was achieved. PEG-NLCs and PVA-NLCs showed a strong interaction with porcine buccal mucosa than uncoated-NLCs. All PRE loaded NLCs formulations revealed fast release characteristics and effective against Streptococcus mutans and S. sanguinis. The mouth spray containing PRE loaded NLCs showed good physical stability without particle aggregation. In addition, the chemical stability of piperine in NLCs was significantly improved during storage at both storage conditions compared to its solution form. Conclusion:The developed PRE loaded polymer coated-NLCs showed high potential to use as a local drug delivery system for reducing the bacterial growth in the oral cavity.

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Section: Introductionmentioning

confidence: 99%

Development and Characterization of Piper Retrofractum Extract Loaded Mucoadhesive Nanostructured Lipid Carriers for Topical Oral Drug Delivery

Srichaivatana

Ounaroon

Tiyaboonchai

2017

Int J Pharm Pharm Sci

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“…Crystal growth and particle aggregation can be controlled by creating high shear forces using a high-speed stirrer. 31…”

Section: Emulsification-solvent Evaporation Techniquementioning

confidence: 99%

Nanosuspension as Promising and Potential Drug Delivery: A Review

Chinthaginjala¹,

Ahad²,

Reddy³

et al. 2022

Int J Life Sci Pharm Res

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In the last decade, nanosuspensions have gained considerable interest as a method for formulating poorly soluble drugs. Because of their cost-effectiveness and technological simplicity compared to liposomes and other colloidal drug carriers, nanoscale systems have recently received a lot of attention as a way of solving problems of solubility. Nanosuspensions are biphasic systems comprising of pure drug particles dispersed in an aqueous vehicle, stabilized by surface active agents. Fabrication of nanosuspension is simple and more advantageous than other approaches. Nanosuspension is a very finely single solid drug particle in an aqueous vessel, stabilized by surfactants for either oral or topical use or for parenteral and pulmonary administration, it can also be used for targeted drug delivery when incorporated in the ocular inserts and mucoadhesive hydrogels, with reduced particle size resulting in increased dissolution rate. This article covers the preparation of nanosuspension by bottom up technology, top down technology, melt emulsification, emulsification- solvent evaporation and supercritical fluid with their advantages and disadvantages, aspects of structure, classification and their drug delivery applications. Nanosuspension can be processed for the drugs which are of hydrophobic in nature quite easily employing stability enhancers, solvents that are of organic and additional ingredients including buffering agents, salts, PEG, osmotic agents and anti-freeze compounds.

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“…There was a substantial shift between 4±2 °C (refrigerator) and 25±2 °C/60±5 percent RH, but the zeta potential fell to 40±2 1C/75±5 percent RH (P<0.05). Zeta potential plays an important role in physical stability [35]. This may be due to lipid coating dissolution that contributes to particle aggregation.…”

Section: Fig 10: Comparison Of % In Vitro Drug Release Profile Of Optimized Dox-lns With Marketed Dox Liposomal Preparationmentioning

confidence: 99%

Optimization and Characterization of Doxorubicin Loaded Solid Lipid Nanosuspension for Nose to Brain Delivery Using Design Expert Software

Shah

Patel²

2021

Int J Pharm Pharm Sci

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Objective: The goal of the current study was to investigate the possible use of solid lipid nanosuspension (SLNs) as a drug delivery method to boost doxorubicin (DOX) brain-targeting performance after intranasal (i. n.) administration. Methods: 33 factorial design was applied for optimization by using lipid concentration, surfactant concentration, and High-speed homogenizer (HSH) stirring time as dependent variables, and their effect was observed on particles size, Polydispersity index (PDI), and entrapment efficiency. Results: With the composition of Compritol® 888 ATO (4.6 % w/v), tween 80 (1.9 % w/v), and HSH stirring time, the optimized formula DOX-SLNs prepared (10 min). Particle size, PDI, zeta potential, entrapment efficiency, percent in vitro release were found to be 167.47±6.09 nm, 0.23±0.02, 24.1 mV, 75.3±2.79, and 89.35±3.27 percent in 24 h, respectively, for optimized formulation (V-O). No major changes in particle size, zeta potential, and entrapping efficiency were found in the stability studies at 4±2 °C (refrigerator) and 25±2 °C/60±5% RH up to 3 mo. Conclusion: Following the non-invasive nose-to-brain drug delivery, which is a promising therapeutic strategy, the positive findings confirmed the current optimized DOX-loaded SLNs formulation.

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Nanosuspension: An Overview

Cited by 19 publications

References 10 publications

Development and Characterization of Piper Retrofractum Extract Loaded Mucoadhesive Nanostructured Lipid Carriers for Topical Oral Drug Delivery

Development and Characterization of Piper Retrofractum Extract Loaded Mucoadhesive Nanostructured Lipid Carriers for Topical Oral Drug Delivery

Nanosuspension as Promising and Potential Drug Delivery: A Review

Optimization and Characterization of Doxorubicin Loaded Solid Lipid Nanosuspension for Nose to Brain Delivery Using Design Expert Software

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