Nanostrucured substrates for surface-enhanced Raman scattering spectroscopy

Bonifacio, Alois

doi:10.1016/b978-0-12-817838-6.00006-1

Cited by 3 publications

(3 citation statements)

References 100 publications

(96 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The use of noble metal nanostructures (NMNs) in paper-based SERS substrates to enhance the Raman signal has various benefits in terms of price, stability, simplicity, and fabrication methods [109]. Paper's porosity offers a huge surface area for assembling nanostructures in high densities.…”

Section: Electrochemical Detectionmentioning

confidence: 99%

Application of Paper-Based Microfluidic Analytical Devices (µPAD) in Forensic and Clinical Toxicology: A Review

et al. 2023

View full text Add to dashboard Cite

The need for providing rapid and, possibly, on-the-spot analytical results in the case of intoxication has prompted researchers to develop rapid, sensitive, and cost-effective methods and analytical devices suitable for use in nonspecialized laboratories and at the point of need (PON). In recent years, the technology of paper-based microfluidic analytical devices (μPADs) has undergone rapid development and now provides a feasible, low-cost alternative to traditional rapid tests for detecting harmful compounds. In fact, µPADs have been developed to detect toxic molecules (arsenic, cyanide, ethanol, and nitrite), drugs, and drugs of abuse (benzodiazepines, cathinones, cocaine, fentanyl, ketamine, MDMA, morphine, synthetic cannabinoids, tetrahydrocannabinol, and xylazine), and also psychoactive substances used for drug-facilitated crimes (flunitrazepam, gamma-hydroxybutyric acid (GHB), ketamine, metamizole, midazolam, and scopolamine). The present report critically evaluates the recent developments in paper-based devices, particularly in detection methods, and how these new analytical tools have been tested in forensic and clinical toxicology, also including future perspectives on their application, such as multisensing paper-based devices, microfluidic paper-based separation, and wearable paper-based sensors.

show abstract

Section: Electrochemical Detectionmentioning

confidence: 99%

Application of Paper-Based Microfluidic Analytical Devices (µPAD) in Forensic and Clinical Toxicology: A Review

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Even in Italy, there is very lively activity on this topic, but the detailed description of these studies is beyond the scope of the present paper. Here, we limit ourselves to mentioning only a few recent and remarkable reviews and book chapters by Italian authors [36][37][38][39][40][41][42]. For more information on the trend of Italian research, one can visit the website www.plasmonica.it (accessed on 14 September 2023).…”

Section: Surface-and Tip-enhanced Raman Scatteringmentioning

confidence: 99%

Exploring Reliable and Efficient Plasmonic Nanopatterning for Surface- and Tip-Enhanced Raman Spectroscopies

Sasso,

Capaccio,

Rusciano

2023

IJMS

View full text Add to dashboard Cite

Surface-enhanced Raman scattering (SERS) is of growing interest for a wide range of applications, especially for biomedical analysis, thanks to its sensitivity, specificity, and multiplexing capabilities. A crucial role for successful applications of SERS is played by the development of reproducible, efficient, and facile procedures for the fabrication of metal nanostructures (SERS substrates). Even more challenging is to extend the fabrication techniques of plasmonic nano-textures to atomic force microscope (AFM) probes to carry out tip-enhanced Raman spectroscopy (TERS) experiments, in which spatial resolution below the diffraction limit is added to the peculiarities of SERS. In this short review, we describe recent studies performed by our group during the last ten years in which novel nanofabrication techniques have been successfully applied to SERS and TERS experiments for studying bio-systems and molecular species of environmental interest.

show abstract

“…In the label‐free approach, each SERS spectrum contains information about the molecules that freely adsorb on substrate surface, driven by the affinity with the surface itself. LF‐SERS spectra of biofluids depend on both the relative concentration of the endo‐ and xeno‐biotics present in a biofluid and their chemical affinity for the substrate’s surface, the latter factor being the most relevant [11]. The surface of the substrate seems to act as a sort of ‘spectroscopic filter’ and greatly limits the types of biofluid components detected by SERS.…”

mentioning

confidence: 99%

The key role of ergothioneine in label‐free surface‐enhanced Raman scattering spectra of biofluids: a retrospective re‐assessment of the literature

Fornasaro

Sergo

2022

FEBS Letters

Self Cite

View full text Add to dashboard Cite

Label-free surface-enhanced Raman scattering (SERS) has recently gained attention in the field of liquid biopsy as a rapid and relatively inexpensive technique that could significantly ease clinical diagnosis and prognosis by investigating a biofluid sample with a laser. Indeed, SERS spectra provide information about a set of metabolites present in the analysed biofluid, thereby offering biochemical insight into specific health conditions. Ergothioneine plays a key role since it is one of the few metabolites in biofluids that are detectable by label-free SERS. In the past decade, many studies characterizing biofluids or other biological samples have unknowingly linked this amino acid with crucial metabolic processes, including inflammation, in a plethora of diseases. However, since the SERS spectrum of ergothioneine has been reported only recently, most past studies inadvertently assigned what are now recognized as the spectral features of this compound to other molecules. The purpose of the present review is to summarize and re-evaluate these studies in the light of the recent SERS characterization of ergothioneine so as to better recognize the role of ergothioneine in many clinical conditions.

show abstract

Nanostrucured substrates for surface-enhanced Raman scattering spectroscopy

Cited by 3 publications

References 100 publications

Application of Paper-Based Microfluidic Analytical Devices (µPAD) in Forensic and Clinical Toxicology: A Review

Application of Paper-Based Microfluidic Analytical Devices (µPAD) in Forensic and Clinical Toxicology: A Review

Exploring Reliable and Efficient Plasmonic Nanopatterning for Surface- and Tip-Enhanced Raman Spectroscopies

The key role of ergothioneine in label‐free surface‐enhanced Raman scattering spectra of biofluids: a retrospective re‐assessment of the literature

Contact Info

Product

Resources

About