Nanostructures formed by cyclodextrin covered procainamide through supramolecular self assembly – Spectral and molecular modeling study

Rajendiran, N.; Mohandoss, T.; Sankaranarayanan, R.

doi:10.1016/j.saa.2014.09.108

Cited by 6 publications

(2 citation statements)

References 39 publications

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“…The slight increase in the absorbance with the addition of CDs can be attributed to the enhanced dissolution of the guest molecule through the detergent action of CD indicating the formation of guest/CD inclusion complexes. A clear isosbestic point observed in SDP and DMSP suggest both molecules forms 1:1 inclusion complexes with CD, whereas in SDBA absence of isosbestic point may rule out the possibility of a single equilibrium involving 1:1 complexation between the drug and CD [23][24][25][26][27][28][29]. The possibilities are proposed for this deviation: (i) more than one guest molecule can be accommodated within a single CD cavity, (ii) due to the space restriction of CD cavity more than one type of complex each having 1:1 stoichiometry may be formed and (iii) the changes detected in the absorption spectra when CD is added to the guest solutions containing methanol (1%) can also made the interaction between both compounds.…”

Section: Absorption and Fluorescence Spectral Studiesmentioning

confidence: 99%

Quantifying the Possible Short- and Long-term Impacts of Superoxide Redox Chemistry on Seawater pH

2015

Can Chem Trans

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Absorption, steady state and time resolved fluorescence spectra of 4,4′-sulfonyldiphenol (SDP), 3,3'-dimethyl 4,4′-sulfonyldiphenol (DMSP), 4,4′-sulfonyldibenzoic acid (SDBA) were studied in the presence of α-and β-cyclodextrins. Both in water and CD, SDP and SDBA exhibit two emission maxima while DMSP exhibit three emission maxima. In β-CD, the rate of enhancement of longer wavelength (LW) emission is higher than that of shorter wavelength (SW) band, where as in α-CD the enhancement of SW is larger than that of LW. The normal Stokes shifted band was originated from the locally excited state and the large Stokes shifted band was due to the emission form a TICT state. In these molecules, the presence of OH or COOH groups at para position of the aromatic rings increase the coplanar geometry in the excited state. Semi-empirical quantum-mechanical calculations were also carried out to assign the encapsulation of the SDP, DMSP and SDBA. PM3 calculations show that most of the SDBA values are different from SDP and DMSP because the values are dependent on the size of the CD cavities and nature of the functional group of the guest.

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Section: Absorption and Fluorescence Spectral Studiesmentioning

confidence: 99%

Quantifying the Possible Short- and Long-term Impacts of Superoxide Redox Chemistry on Seawater pH

2015

Can Chem Trans

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“…However, in the profile of the inclusion complex, the peak that represented water loses was vastly reduced in intensity and shifted to a lower temperature. This result suggested that a structure of lower water capacity was formed, because of the extrusion of water molecules from β-CD cavities, resulting from DMP being embedded into β-CD cavities [17].…”

Section: Preparation and Structural Analysis Of Cmcs-g-β-cd•dmpmentioning

confidence: 99%

Inclusion-Interaction Assembly Strategy for Constructing pH/Redox Responsive Micelles for Controlled Release of 6-Mercaptopurine

Tan¹,

Zheng²,

Zhang³

et al. 2015

MSA

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An inclusion-interaction assembly strategy was used to construct novel pH/redox responsive core-shell micelles with hydrophobic drug as the core and hydrophilic polymer as the shell. At first, a dimer of hydrophobic drug 6-mercaptopurine and a hydrophilic β-CD grafted carboxymethyl chitosan were synthesized. Then, a novel amphiphilic inclusion complex was prepared with the dimer being partially embedded into the cavity of β-CD moiety. It self-assembled into pH/redox responsive core-shell micelles in distilled water. TEM confirmed that the micelles possessed a spherical core-shell configuration with a mean size of about 160 nm. DLS showed that the micelles were stable in aqueous solution. Their particle diameters altered with pH values as well as glutathione (GSH) concentrations and respectively attained a maximum value at pH 6.0 and 20 mM GSH. Release profiles of 6-mercaptopurine showed a low release rate (about 27 wt% after 48 h) in pH 7.4 medium with 10 μM GSH, and a marked increase (over 88 wt% after 48 h) in pH 5.0 medium with 20 mM GSH. In vitro cytotoxicity test showed that the micelles had a dose-dependent toxicity for HeLa cells, indicating a great potential for controlled release of 6-mercaptopurine in tumor cells.

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Supramolecular host−guest interactions of dibenzoylmethanatoboron difluoride with β-cyclodextrin

Ionov,

Yurasik,

Ionova

et al. 2024

Journal of Molecular Liquids

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Nanostructures formed by cyclodextrin covered procainamide through supramolecular self assembly – Spectral and molecular modeling study

Cited by 6 publications

References 39 publications

Quantifying the Possible Short- and Long-term Impacts of Superoxide Redox Chemistry on Seawater pH

Quantifying the Possible Short- and Long-term Impacts of Superoxide Redox Chemistry on Seawater pH

Inclusion-Interaction Assembly Strategy for Constructing pH/Redox Responsive Micelles for Controlled Release of 6-Mercaptopurine

Supramolecular host−guest interactions of dibenzoylmethanatoboron difluoride with β-cyclodextrin

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