Nanostructured platelet-rich plasma: state of art in dental treatments

Abstract

Objectives: Reviewing information available about platelet-rich plasma (PRP) applied to dental treatments, introducing the general concept of PRP, as well as analyzing actual data about, and challenges faced by, the dental field. Data & sources: The current study analyzed the most informative publications about PRP application available in this field and gathered the maximum information about it as possible. Conclusions: PRP use, either alone or in association with other biomaterials, can significantly favor different fields such as tissue engineering, since it is an innovative technique that attracts the interest of clinicians and basic scientists. However, it is necessary conducting better designed and controlled experiments to enable successful tissue healing based on PRP use. Clinical significance: The current review can be used by clinicians as source of information about the actual rules and protocols adopted in the herein addressed field, besides providing specific examples of such applications.KeywordsPlatelet-rich plasma; Dental treatment; Plateletgrowth factors; Nanotechnology; Bone regeneration; Surgery.

Nanostructure characteristics of three types of platelet-rich fibrin biomaterial: a histological and immunohistochemical study

“…Platelets are essential for tissue repair, as they are the first cell fragments to reach damaged areas and contain large amounts of bioactive proteins [4]. Among advanced regenerative agents, autologous platelet concentrates have proven to be an effective and low-cost regenerative modality with the ability to stimulate wound healing processes and accelerate angiogenesis [5,6].…”

“…Among advanced regenerative agents, autologous platelet concentrates have proven to be an effective and low-cost regenerative modality with the ability to stimulate wound healing processes and accelerate angiogenesis [5,6]. Platelet-rich plasma (PRP), a first-generation platelet concentrate, was obtained from centrifuged blood with an anticoagulant [4]. PRP is defined as a nanostructured protein because of the nanometric scale of these particles, especially nanometric PRP exosomes (diameter smaller than 50 nm) [4,7].…”

“…Platelet-rich plasma (PRP), a first-generation platelet concentrate, was obtained from centrifuged blood with an anticoagulant [4]. PRP is defined as a nanostructured protein because of the nanometric scale of these particles, especially nanometric PRP exosomes (diameter smaller than 50 nm) [4,7].…”