Nanostructured materials functionalized with metal complexes: In search of alternatives for administering anticancer metallodrugs

Synthesis, physico-chemical characterization and bacteriostatic study of Pt complexes with substituted amine ligands

“…The position of these peaks is influenced by the nitrogen atoms in the aromatic ring. For νPt-N and νPt-Cl, the lowest wavenumbers were found in the case of [Pt(pa) 2 Cl 2 ], which means that these bonds are stronger compared to those in the other complexes.…”

“…Furthermore, on the DTA curve of 2 a small exothermic peak is observed at 204 °C without significant mass change at this temperature. The thermal decomposition of compound [Pt(aph) 2 Cl 2 ] (3) is followed by an exothermic effect with a small peak at 217 °C due to its oxygen content. The thermal properties of the samples in air are somewhat different from those in nitrogen.…”

“…Since the discovery of anticancer activity of cisplatin, high efforts have been made to find more active and less toxic neoplastic agents for cancer treatment in humans [2]. High number of different platinum complexes is synthesized with the aim to understand better the mode of action of platinum based antitumor drugs and to get new ones with fewer side effects.…”

“…Since the thermal properties of biological active compounds are crucial for their future application, the other aim of this work is the detailed thermal analysis of the synthesized coordination compounds. Namely, [Pt(an) 2 Cl 2 ] (1), [Pt(pa) 2 Cl 2 ] (2) and [Pt(aph) 2 Cl 2 ] (3) were prepared, where an is 2-aminonaphthalene, pa is 2-pyrimidinamine and aph is 4-anilinophenol. Different synthetic methods and properties of compounds 1 [34] and 2 [35] were published earlier.…”

Copper(II) Complexes Based on Aminohydroxamic Acids: Synthesis, Structures, In Vitro Cytotoxicities and DNA/BSA Interactions

“…Many of complexes have been found to be active in the restrained reproduction of cancer cells [1][2][3][4][5], and some of them have been used in clinical treatments. Metal complexes with high anticancer activity and non-covalent DNA or protein binding properties have played an important role in antitumor chemotherapy and developed an active research area in metal-based drugs [6]. DNA is the most important target for antitumorals because of its central role in replication and transcription.…”