Nanostructured materials based on polymerizable amphiphiles

Miller, Seth A; Ding, James; Gin, Douglas L.

doi:10.1016/s1359-0294(99)90018-3

Cited by 60 publications

(49 citation statements)

References 45 publications

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“…These molecular building blocks contain the desired charge, polarization, or chemical functionalities that will affect intermolecular interactions such as van der Waals forces, hydrogen bonding, polar attractions, and͞or hydrophobic interactions (7)(8)(9). These interactions dictate the subsequent assembly into supramolecular structures (4,(9)(10)(11). Complementary to these synthetic approaches, we explore whether individual units such as small molecular ligands or large molecules such as proteins can be positioned with nanometer precision by using nanoengineering methodologies.…”

mentioning

confidence: 99%

Positioning protein molecules on surfaces: A nanoengineering approach to supramolecular chemistry

Liu

Amro

2002

Proc. Natl. Acad. Sci. U.S.A.

183

158

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We discuss a nanoengineering approach for supramolecular chemistry and self assembly. The collective properties and biofunctionalities of molecular ensembles depend not only on individual molecular building blocks but also on organization at the molecular or nanoscopic level. Complementary to ''bottom-up'' approaches, which construct supramolecular ensembles by the design and synthesis of functionalized small molecular units or large molecular motifs, nanofabrication explores whether individual units, such as small molecular ligands, or large molecules, such as proteins, can be positioned with nanometer precision. The separation and local environment can be engineered to control subsequent intermolecular interactions. Feature sizes as small as 2 ؋ 4 nm 2 (32 alkanethiol molecules) are produced. Proteins may be aligned along a 10-nm-wide line or within two-dimensional islands of desired geometry. These high-resolution engineering and imaging studies provide new and molecular-level insight into supramolecular chemistry and self-assembly processes in bioscience that are otherwise unobtainable, e.g., the influence of size, separation, orientation, and local environment of reaction sites. This nanofabrication methodology also offers a new strategy in construction of two-and three-dimensional supramolecular structures for cell, virus, and bacterial adhesion, as well as biomaterial and biodevice engineering. S upramolecular chemistry has become an area of intense research (1-4), partly inspired by biological ensembles in nature, such as collagen and enzymes or protein assemblies in general. In nature, the collective properties and biofunctionalities of these ensembles depend not only on the individual molecular units but also (perhaps even more importantly) on the organization at the molecular or nanoscopic level (1, 2, 4, 5). Such organization dependence can be attributed to polyvalent interactions in biological systems (6). ''Bottom-up'' approaches have been taken to mimic nature and have resulted in creative synthesis of small molecular units (7,8) and large molecular motifs (9). These molecular building blocks contain the desired charge, polarization, or chemical functionalities that will affect intermolecular interactions such as van der Waals forces, hydrogen bonding, polar attractions, and͞or hydrophobic interactions (7-9). These interactions dictate the subsequent assembly into supramolecular structures (4, 9-11). Complementary to these synthetic approaches, we explore whether individual units such as small molecular ligands or large molecules such as proteins can be positioned with nanometer precision by using nanoengineering methodologies. The separation and local environment can be engineered to influence subsequent intermolecular interactions.Micrometer-sized patterns of biomolecules can be produced by using relatively well known microfabrication technologies. Without using templates, DNA micropatterns may be directly produced by using photolithography (12)(13)(14). Micropatterns of proteins have also been ...

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mentioning

confidence: 99%

Positioning protein molecules on surfaces: A nanoengineering approach to supramolecular chemistry

Liu

Amro

2002

Proc. Natl. Acad. Sci. U.S.A.

183

158

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“…The main principles of synthesis of the monomer (N-acryloyl-11-aminoundecanoic acid, AAUA) are described in [16]. The critical micelle concentration of AAUA in water (CMC 1 ) is 0.12 g L −1 .…”

Section: Methodsmentioning

confidence: 99%

“…Recently, polymerizable surfactants have generated considerable interest due to their wide possible applications [6,7], e.g., as components of pseudostationary phase in micellar chromatography [8][9][10], drug carriers [11][12][13], and "building blocks" for molecular design of nanoparticles and nanostructured polymer materials [14][15][16][17]. Poly(N-acryloyl-11-aminoundecanoic acid), PAAUA, and its sodium salt are among possible contenders for molecular cores in constructing nanoparticles with surface functional groups, and poly(-acrylic acid) is used in encapsulation of various biological preparations [18].…”

Section: Introductionmentioning

confidence: 99%

Conformational, optical, electro-optical, and dynamic characteristics of cross-linked poly(N-acryloyl-11-aminoundecanoic acid)

et al. 2014

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Polymerizable surfactants now attract a great interest due to high potential of their practical application as components of pseudostationary phase in micellar chromatography, drug carriers, and "building blocks" for molecular design of nanoparticles and nanostructured polymer materials, for encapsulation of various biological preparations. In the present work, we have studied poly(N-acryloyl-11-aminoundecanoic acid) (cross-linked comb-like polymer). Cross-linked polymers were obtained via copolymerization of the surfactant bearing double bond in hydrophobic tail with hydrophobic bifunctional cross-linker in micellar solution. Of special interest was the comparison between cross-linked and non-cross-linked polymers and influence of alkaline medium on characteristics of these samples. Non-cross-linked polymers were obtained by hydrolysis of the cross-linked product (treating with NaOH). The mixture of cyclohexanol and dioxane (1:1 volume ratio) was used as a solvent. Detailed studies of the obtained polymers by viscometry, dynamic light scattering, flow birefringence, and equilibrium and nonequilibrium electric birefringence were performed. It was established that during cross-linking process, two types of bonds are formed (the ones inside individual molecules and between several polymer chains). It was shown that crosslinked macromolecular nanoparticles can be transformed into comb-like polymers.

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“…In synthetic polymeric systems, control of nanostructure has been achieved via two distinct approaches: one using block copolymers and the other using surfactants. A number of reviews that discuss different aspects of both approaches to the generation of polymeric nanostructures have appeared recently [1][2][3][4][5][6][7][8][9][10][11][12][13][14]. Block copolymers form nanometer-size aggregates of various sizes and shapes, due to the intrinsic property of structurally dissimilar macromolecular segments to phase separate in bulk.…”

Section: Introductionmentioning

confidence: 99%

Nanostructured Polymers

Ramakrishnan

2004

The Chemistry of Nanomaterials

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Nanostructured materials based on polymerizable amphiphiles

Cited by 60 publications

References 45 publications

Positioning protein molecules on surfaces: A nanoengineering approach to supramolecular chemistry

Positioning protein molecules on surfaces: A nanoengineering approach to supramolecular chemistry

Conformational, optical, electro-optical, and dynamic characteristics of cross-linked poly(N-acryloyl-11-aminoundecanoic acid)

Nanostructured Polymers

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