Nanostructured magnetic nanocomposites as MRI contrast agents

Abstract

The development of water-soluble nanostructured magnetic nanocomposites based on hydrophobic magnetic nanoparticle assemblies using an organic functional coating for MRI contrast agent applications was discussed.

HoF3 and DyF3 Nanoparticles as Contrast Agents for High‐Field Magnetic Resonance Imaging

“…The slopes of the curves gave the relaxivity values r 1 and r 2 shown in Table 1 . The following comments can be made in view of the relaxivity values obtained: (1)Relaxivity measurements performed at 9.4 T showed r 2 values much higher than the r 1 ones for all three nanoparticle types, which indicate that the synthesized LnF 3 NPs are adequate as negative contrast agents . This behavior is due to the anisotropic 4f electron ground state of both Dy 3+ and Ho 3+ ions, which give rise to a short electronic relaxation time ( T 1e ) on the order of 10–13 sec, leading to a minor contribution to T 1 relaxation, according to the SBM (Salomon‐Bloembergen‐Morgan) theory .…”

High performance magneto-fluorescent nanoparticles assembled from terbium and gadolinium 1,3-diketones

“…Novel MRI CA based on gadolinium-containing nanoparticles show enhanced relaxation parameters compared to commercial specimens1323242526. The slowed down rotation of magnetic ions is the main reason for better relaxivity of the nanoparticulate CA versus mononuclear gadolinium complexes.…”

Magnetic iron oxide nanoparticles: Recent trends in design and synthesis of magnetoresponsive nanosystems

“…polar carriers, the oleic acid hydrophobic coating of IONPs organized in magnetic nanoparticle ensembles is particularly important in improving relaxivity in MR imaging, according to a recent evaluation [75]. The microwave assisted coprecipitation synthesis in the presence of in situ surface modifiers like oleic acid results in much lower degree of IONPs' aggregation than that observed in their absence [71].…”