Nanostructured magnetic Mg2SiO4-CoFe2O4 composite scaffold with multiple capabilities for bone tissue regeneration

Bigham, Ashkan; Aghajanian, Amir Hamed; Behzadzadeh, Shima; Sokhani, Zahra; Shojaei, Sara; Kaviani, Yeganeh; Hassanzadeh-Tabrizi, S.A.

doi:10.1016/j.msec.2019.01.096

Cited by 52 publications

(44 citation statements)

References 48 publications

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“…All scaffolds were prepared with dimensions of 30 × 10 × 0.01 mm 3 and were deformed with a 10 N load cell with a speed rate of 10 mm/ min. The Young's modulus of samples was calculated based on the linear area of the stress-strain curve (n = 3).…”

Section: Mechanical Analysismentioning

confidence: 99%

“…1 Various methods-self-assembly, phase separation, gas foaming/ particulate leaching, emulsification freeze-drying, and electrospinning have been adopted for fabricating tissue engineering scaffolds. 2,3 Among them, electrospinning method (EM) has attracted enormous attentions because of its easy fabrication process and cost-effectiveness. This method is capable of applying various materials to yield a scaffold with relatively high surface area.…”

Section: Introductionmentioning

confidence: 99%

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Electrospun captopril‐loadedPCL‐carbon quantum dots nanocomposite scaffold: Fabrication, characterization, and in vitro studies

Ghorghi

Rafienia

Nasirian

et al. 2020

Polymers for Advanced Techs

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Electrospinning as an effective and accessible method is known to yield scaffolds with desired physical, chemical, and biological properties for tissue engineering. In the present study, captopril (CP)-loaded polycaprolactone (PCL)/carbon quantum dots (CQDs) nanocomposite scaffolds were fabricated for bone tissue regeneration. The microstructure and hydrophilicity/hydrophobicity ratio of scaffolds were assessed by scanning electron microscopy and wettability test, respectively. The results showed that the presence of CQDs and CP in the scaffolds decreased the fiber diameter (1180 ± 281.5-345 ± 110 nm) and also it led to an increase in the surface hydrophilicity (137-0) of scaffolds. Evaluation of the scaffolds' functional groups was performed using Attenuated Total Reflectance-Fourier Transform Infrared spectroscopy. The ultimate tensile strength of scaffolds was in the range of 6.86 ± 0.00 to 22.09 ± 0.06 MPa. Distribution of CQDs in the scaffolds' fibers was investigated by transmission electron microscopy and fluorescent spectrometer. The cell viability, attachment, proliferation, and alkaline phosphatase (ALP) activity of scaffolds were assessed in vitro. Based on the overall results, the scaffold containing CQDs and CP led to a significant increase in the cells' proliferation and ALP activity. Therefore, the PCL/CQDs/CP is recommended as a potential nanocomposite scaffold for bone tissue regeneration.

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Section: Mechanical Analysismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Electrospun captopril‐loadedPCL‐carbon quantum dots nanocomposite scaffold: Fabrication, characterization, and in vitro studies

Ghorghi

Rafienia

Nasirian

et al. 2020

Polymers for Advanced Techs

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“…Bigham et al grafted a magnetic Mg 2 SiO 4 -CoFe 2 O 4 composite scaffold on the surface of warp-based apatite particles. Compared with the traditional HA particles, FeHA improves the survival rate of osteoblasts under the effect of an external magnetic field and affects the cell morphology (Bigham et al, 2019 ). Parfenov et al used magnetic particles and apatite as bone tissue engineering scaffolds.…”

Section: Preparation Of Magnetic Nanomaterialsmentioning

confidence: 99%

“…The interaction with bone cells and magnetic mechanical stimulation still needs further study. Bigham applied a Mg 2 SiO 4 -CoFe 2 O 4 nanocomposite scaffold as a multifunctional magnetic scaffold to eradicate remaining bone cancerous tissues after surgery (Bigham et al, 2019 ) ( Figure 9 ). It is a promising attempt for bone tissue repair and defect regeneration with magnetic nanomaterials along with a 3D scaffold.…”

Section: Preparation Of Magnetic Nanomaterialsmentioning

confidence: 99%

Recent Advances of Magnetic Nanomaterials in Bone Tissue Repair

et al. 2020

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The magnetic field has been proven to enhance bone tissue repair by affecting cell metabolic behavior. Magnetic nanoparticles are used as biomaterials due to their unique magnetic properties and good biocompatibility. Through endocytosis, entering the cell makes it easier to affect the physiological function of the cell. Once the magnetic particles are exposed to an external magnetic field, they will be rapidly magnetized. The magnetic particles and the magnetic field work together to enhance the effectiveness of their bone tissue repair treatment. This article reviews the common synthesis methods, the mechanism, and application of magnetic nanomaterials in the field of bone tissue repair.

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“…It should be mentioned that sintered HA suffers from forming carbonated HA on its surface in a few days. [ 3 4 5 ]…”

Section: Introductionmentioning

confidence: 99%

On the bioactivity and mechanical properties of gehlenite nanobioceramic: A comparative study

et al. 2020

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Nanostructured magnetic Mg2SiO4-CoFe2O4 composite scaffold with multiple capabilities for bone tissue regeneration

Cited by 52 publications

References 48 publications

Electrospun captopril‐loadedPCL‐carbon quantum dots nanocomposite scaffold: Fabrication, characterization, and in vitro studies

Electrospun captopril‐loadedPCL‐carbon quantum dots nanocomposite scaffold: Fabrication, characterization, and in vitro studies

Recent Advances of Magnetic Nanomaterials in Bone Tissue Repair

On the bioactivity and mechanical properties of gehlenite nanobioceramic: A comparative study

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