Nanostructured Lipid Carriers (NLC) for the Topical Delivery of Lutein

Paolino, Donatella; Stancampiano, Annalisa H.S.; Cilurzo, Felisa; Cosco, Donato; Puglisi, Giovanni; Pignatello, Rosario

doi:10.2174/2210304x11101010032

Cited by 6 publications

(3 citation statements)

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“…Hence, preparing Posaconazole loaded nanostructured lipid carriers gel for topical delivery to avoid such side effects of drugs and to improve the bioavailability, patient compliance for different topical fungal infections. 29,30 The goal of this study was to create Posaconazole-loaded NLCs utilizing a high homogenization approach followed by sonication. Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), and X-ray diffraction (XRD) examinations were used to characterize NLCs.…”

Section: Introductionmentioning

confidence: 99%

Formulation and evaluation of posaconazole loaded nanostructured lipid carriers for topical drug delivery system

Ghurghure¹,

Jadhav²,

Kale³

et al. 2022

CTPPC

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The aim of the present study was to formulate and evaluate Posaconazole loaded NLCs gel using solid lipid as GMS, liquid lipid as oleic acid and surfactants as tween 80 and span 80, with the help of high-speed homogenization followed by sonication technique to improve the bioavailability, to avoid the oral side effects, to achieve the site-specific delivery and to improve the patient compliance. NLCs of Posaconazole was prepared with different drug: carrier ratios using high speed homogenization followed by sonication technique. % entrapment efficiency for F3 batch of NLC was found to be more than 95%. SEM studies were carried out and depending on it F3 batch was found to have particle size range 200nm which was selected as optimized NLCs batch. IR, XRD and DSC were performed to identify the physicochemical interaction between drug and optimized formulation. The optimized NLCs was then incorporated into gel base to form Posaconazole loaded NLCs gel. The prepared NLCs gel were evaluated for viscosity, pH, spread-ability, extrudability and in-vitro drug release studies. It was found to be 34666 cps, 5.7, 12.22 ±0.8 cm, 85.34% and drug release of NLCs gel within 6hrs was 98.62% respectively. The obtained data for in-vitro drug release was putted in various mathematical kinetic models. Hence, F3 batch was selected as optimized batch.

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Section: Introductionmentioning

confidence: 99%

Formulation and evaluation of posaconazole loaded nanostructured lipid carriers for topical drug delivery system

Ghurghure¹,

Jadhav²,

Kale³

et al. 2022

CTPPC

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“…In an in vivo model of UV-induced skin erythema, the lutein-loaded NLC demonstrated enhanced photo-protective effects compared to the commercial suspension when applied prior to erythema induction. This study also demonstrated the possibility of converting a liquid formulation into a solid, modified release nanocarrier with improved manageability [47] .…”

Section: Applications Of Nlc: 471 Nlcs In Dermal Applicationmentioning

confidence: 73%

Nanostructured Lipid Carrier for Hyperpigmentation Treatment - a Dermal Prospective

et al. 2024

IJFMR

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The normal human skin is exposed to different types of infection like wrinkles, pigmentation, acne, pimples in which pigmentation is most common in women over 30-40 years. The field of nanotechnology is currently intensely exploited for drug delivery technology for passive and active targeting via various routes of administration, such things can be effectively treated by incorporating the drug, loaded in a Nanostructured lipid carrier (NLC). NLCs have shown potential in delivering poorly soluble active components and in depigmenting. NLC springs up as the second generation of lipid nanoparticles to overcome the shortcomings of first generation through the topical route. NLC in topical administration provides some added advantages like increasing skin hydration and modified release profile and increase in skin penetration leading to avoidance of systemic absorption. NLCs are composed of biocompatible lipids, surfactants, and cosurfactants which help enhance drug loading capacity and stabilize the formulation. NLC's remarkable physicochemical and subsequently biocompatible qualities have created an ongoing need for the development of beneficial and safe drug delivery methods. The key attributes of NLC that make them a promising drug delivery system are ease of preparation, biocompatibility, the feasibility of scale-up, non-toxicity, improved drug loading, and stability Their ingredients have a special impact on the end product's physicochemical characteristics and efficacy. The present review aims to focus on the recent advancement in the preparation, characterization, and applications of NLC in treating hyperpigmentation.

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“…This method is non-destructive, as no dilution of the sample is necessary, and gives the information on the kind of destabilization process. Turbiscan measurements are based on the variation of the droplet volume fraction (creaming/sedimentation) or mean size (coalescence) which result in the variation of backscattering and transmission signals (Paolino et al, 2011). These signals occur as a function of time (and particle migration) and are graphically reported in the form of positive (backscattering increase) or negative peaks (backscattering decrease).…”

Section: Characterization Of Forskolin-loaded Nlcmentioning

confidence: 99%

NLC as a potential carrier system for transdermal delivery of forskolin*

et al. 2018

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Nanostructured lipid carriers (NLC) composed of the substances generally recognized as safe (GRAS) were obtained by using a hot high-pressure homogenization technique (HPH). The influence of the number of homogenization cycles and concentration of a decyl glucoside surfactant on the NLC properties were studied. The system's stability was assessed by macroscopic observation, light backscattering and zeta potential measurements. NLC particle size was measured using dynamic light scattering (DLS). The kinetically stable formulations were loaded with forskolin and selected for in vitro drug permeation study using the Franz cell method. Concentration of forskolin in the receptor solution (i.e. ethanol/PBS mixture) was analyzed with high performance liquid chromatography (HPLC) with UV detection. The obtained results have shown that NLC formulations could be used as effective carriers for forskolin permeation through the skin.

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Nanostructured Lipid Carriers (NLC) for the Topical Delivery of Lutein

Cited by 6 publications

References 0 publications

Formulation and evaluation of posaconazole loaded nanostructured lipid carriers for topical drug delivery system

Formulation and evaluation of posaconazole loaded nanostructured lipid carriers for topical drug delivery system

Nanostructured Lipid Carrier for Hyperpigmentation Treatment - a Dermal Prospective

NLC as a potential carrier system for transdermal delivery of forskolin*

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