Nanostructured Lipid Carriers-Hydrogels System for Drug Delivery: Nanohybrid Technology Perspective

Azhar, Sharifah Nurfadhlin Afifah Syed; Ashari, Siti Efliza; Zainuddin, Norhazlin; Hassan, Masriana

doi:10.3390/molecules27010289

Cited by 27 publications

(10 citation statements)

References 121 publications

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“…Keyword co-occurrence analysis reflected the developing trends and hot spots of NHs ( Figure 8 ). Due to the special construction and physical properties of NHs we mentioned above, the hot spots are in vitro drug delivery of NHs, injectable hydrogels, and the application of 3D printing, especially in the simulation of bone (Asadi et al, 2018; Gorantla et al, 2019; Du et al, 2021; Shahid et al, 2021 ; Syed Azhar et al, 2022 ). The keywords appearing in Figure 8 are connected closely and have strong centrality, which shows that the application of NHs has developed to different orientations continually and rapidly ( Motealleh et al, 2021a ).…”

Section: Discussionmentioning

confidence: 99%

A Bibliometric and Visual Analysis of Nanocomposite Hydrogels Based on VOSviewer From 2010 to 2022

Zhao

Zhang

2022

Front. Bioeng. Biotechnol.

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Background: Nanocomposite hydrogels (NHs) are stable composite materials formed by dispersing nanomaterials in hydrogels and have broad development prospects in the biomedical field. In this study, we aimed to systematically and comprehensively evaluate the trends and hot spots of biomedical applications of NHs from 2010 to 2022.Methods: In total, 713 articles and reviews related to NH applications in the biomedical field from 2010 to 2022 were retrieved from the Web of Science Core Collection (WOSCC). Two scientometric software programs, VOSviewer and Microsoft Excel 2019, were used to visually perform bibliometric analysis in terms of research trends, sources, the contribution of journals, co-citation, and the co-occurrence of keywords.Results: From 1 January 2010 to 3 February 2022, the number of annual scientific publications about NHs exhibited an upward trend, and research articles were published in a larger proportion (more than 77%). The top three countries in NH research were China, the United States, and India. Meanwhile, Tabriz University of Medical Sciences, the Chinese Academy of Sciences, and Tshwane University of Technology were the most active and contributive. In the contribution of journals, the journal Advanced Functional Materials had the highest number of publications, and the journal Int J Biol Macro had the most citations. Varaprasad K was the most prolific author, and Haraguchi K ranked first among co-cited authors. In the ranking of frequency in the co-cited references, Nanocomposite Hydrogels for Biomedical Applications, published by Gaharwar AK, was the most frequently cited reference. The keyword with the highest frequency was “drug delivery.”Conclusion: This study performed a full overview of NHs using bibliometrics and identified current trends and hot spots. This information may help researchers focusing on NHs to identify developments in this field.

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Section: Discussionmentioning

confidence: 99%

A Bibliometric and Visual Analysis of Nanocomposite Hydrogels Based on VOSviewer From 2010 to 2022

Zhao

Zhang

2022

Front. Bioeng. Biotechnol.

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“…107 The typical size range of these nanostructures is between 200 and 400 nm. 110 Different models of NLCs have been reported. 30,111 The first type is the imperfect type, which utilizes spatially different lipids that result in the development of imperfections in the crystal lattice.…”

Section: Nanostructured Lipid Carriers (Nlcs)mentioning

confidence: 99%

Lipid nanoparticle-based formulations for high-performance dentistry applications

et al. 2023

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“…The delivered substances can be included both inside the liposome in the aqueous phase (if it is water soluble), in the lipid double membrane (if it is lipid soluble and hydrophobic) or in both compartments of liposomes. NLCs are composed of both solid and liquid lipids as a core matrix [ 74 , 79 ]. NLCs are the most convenient vehicles for delivery of water insoluble drugs.…”

Section: Essentialsmentioning

confidence: 99%

Nanotechnology-Based RNA Vaccines: Fundamentals, Advantages and Challenges

Pozharov

Minko

2023

Pharmaceutics

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Over the past decades, many drugs based on the use of nanotechnology and nucleic acids have been developed. However, until recently, most of them remained at the stage of pre-clinical development and testing and did not find their way to the clinic. In our opinion, the main reason for this situation lies in the enormous complexity of the development and industrial production of such formulations leading to their high cost. The development of nanotechnology-based drugs requires the participation of scientists from many and completely different specialties including Pharmaceutical Sciences, Medicine, Engineering, Drug Delivery, Chemistry, Molecular Biology, Physiology and so on. Nevertheless, emergence of coronavirus and new vaccines based on nanotechnology has shown the high efficiency of this approach. Effective development of vaccines based on the use of nucleic acids and nanomedicine requires an understanding of a wide range of principles including mechanisms of immune responses, nucleic acid functions, nanotechnology and vaccinations. In this regard, the purpose of the current review is to recall the basic principles of the work of the immune system, vaccination, nanotechnology and drug delivery in terms of the development and production of vaccines based on both nanotechnology and the use of nucleic acids.

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Nanostructured Lipid Carriers-Hydrogels System for Drug Delivery: Nanohybrid Technology Perspective

Cited by 27 publications

References 121 publications

A Bibliometric and Visual Analysis of Nanocomposite Hydrogels Based on VOSviewer From 2010 to 2022

A Bibliometric and Visual Analysis of Nanocomposite Hydrogels Based on VOSviewer From 2010 to 2022

Lipid nanoparticle-based formulations for high-performance dentistry applications

Nanotechnology-Based RNA Vaccines: Fundamentals, Advantages and Challenges

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