Nanostructured Lipid Carriers for Transdermal Drug Delivery

Hassan, Doaa H; SHOHDY, JOSEPH N.; EL-NABARAWI, MOHAM; El-Setouhy, Doaa Ahmed; Abdellatif, Menna M.

doi:10.22159/ijap.2022v14i4.44564

Cited by 6 publications

(1 citation statement)

References 48 publications

(52 reference statements)

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“…The developed method was applied to determine the drug loading and drug entrapment efficiency study of curcumin and EGCG-loaded nanoparticles prepared in a carbohydrate matrix system [31].…”

Section: Purposed Methods For Applicationmentioning

confidence: 99%

Validation, Stability Studies, and Simultaneous Estimation of Co-Encapsulated Curcumin, Epigallocatechin Gallate Nanoformulation by Rp-HPLC Method

BHUTIA

Bera

2022

Int J App Pharm

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Objective: A new reverse-phase high-performance liquid chromatography (RP-HPLC) method was developed to simultaneously determine curcumin and epigallocatechin gallate (EGCG) in novel nanoformulation. Methods: The high-performance liquid chromatography (HPLC) method was achieved by using a Thermo Scientific Hypersil Base Deactivated Silica (BDS) C18 column (25 cm X 4.6 mm, 5 µm) at 35 °C column oven temperature. The chromatographic procedure was performed with a mobile phase of acetonitrile and 0.025 M (pH 4.0) potassium dihydrogen phosphate (KH2PO4) buffer by gradient mode of elution. The injection volume was 20 µl, and the flow rate was 1.5 ml/min, with ultraviolet (UV) detection using a diode array detector (DAD) at a 268 nm isosbestic wavelength. Results: Drug entrapment efficiency studies were performed with co-encapsulated EGCG and curcumin nanoformulation, which were found to be 94.35 % and 95.12 %, respectively. This shows that the developed method is highly effective. EGCG and curcumin were eluted at 3.9 min and 10.7 min, respectively. The linearity range was 25-175 µg/ml for EGCG and 12.5-100 µg/ml for curcumin. The correlation coefficient was 0.991 for EGCG and 0.999 for curcumin from the linearity curve, which indicates that the method can produce good sensitivity. Forced degradation studies were conducted in acidic, basic, oxidative, thermal, photolytic, and UV stress conditions, where all the degradation peaks were monitored. Conclusion: The developed method was linear, simple, rapid, robust, and precise. It could be used to quantify EGCG and curcumin simultaneously in various nanoformulations for in vivo and in vitro applications.

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Section: Purposed Methods For Applicationmentioning

confidence: 99%

Validation, Stability Studies, and Simultaneous Estimation of Co-Encapsulated Curcumin, Epigallocatechin Gallate Nanoformulation by Rp-HPLC Method

BHUTIA

Bera

2022

Int J App Pharm

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Insight into central nervous system targeted nanostructured lipid carriers via the nose to brain pathway

Das,

Sarma,

Baruah

et al. 2024

RSC Pharm.

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A Comprehensive Review on Potential Chemical and Herbal Permeation Enhancers Used in Transdermal Drug Delivery Systems

Raghav,

Verma,

Monika

2024

RADDF

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Using skin patches to deliver drugs is dependable and doesn't have the same issues as permeation enhancers, which help drugs get through the skin but struggle because of the skin's natural barrier. Strategies are required to increase topical bioavailability to enhance drug absorption. Natural compounds offer a promising solution by temporarily reducing skin barrier resistance and improving drug absorption. Natural substances allow a wider variety of medications to be distributed through the stratum corneum, offering a dependable approach to enhancing transdermal drug delivery. Natural substances have distinct advantages as permeability enhancers. They are pharmacologically effective and safe, inactive, non-allergenic, and non-irritating. These characteristics ensure their suitability for use without causing adverse effects. Natural compounds are readily available and well tolerated by the body. Studies investigating the structure-activity relationship of natural chemicals have demonstrated significant enhancer effects. By understanding the connection between chemical composition and enhancer activity, researchers can identify effective natural compounds for improving drug penetration. In conclusion, current research focuses on utilizing natural compounds as permeability enhancers in transdermal therapy systems. These substances offer safety, non-toxicity, pharmacological inactivity, and non-irritation. Through structure-activity relationship investigations, promising advancements have been made in enhancing drug delivery. Using natural compounds holds enormous potential for improving the penetration of trans-dermally delivered medications.

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Nanostructured Lipid Carriers for Transdermal Drug Delivery

Cited by 6 publications

References 48 publications

Validation, Stability Studies, and Simultaneous Estimation of Co-Encapsulated Curcumin, Epigallocatechin Gallate Nanoformulation by Rp-HPLC Method

Validation, Stability Studies, and Simultaneous Estimation of Co-Encapsulated Curcumin, Epigallocatechin Gallate Nanoformulation by Rp-HPLC Method

Insight into central nervous system targeted nanostructured lipid carriers via the nose to brain pathway

A Comprehensive Review on Potential Chemical and Herbal Permeation Enhancers Used in Transdermal Drug Delivery Systems

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