Nanostructured lipid carriers accumulate in atherosclerotic plaques of ApoE−/− mice

Abstract

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Nanoparticles in the diagnosis and treatment of vascular aging and related diseases

“… 96 , 102 Compared to SLNs, NLCs possess higher drug entrapment efficiencies, higher drug loading capacities, higher drug stabilities, lower drug expulsion during storage, and better solubility, 103 thus, they are promising drug carriers in vascular aging-related diseases. 104 – 106 …”

A comparative biodistribution study of polymeric and lipid-based nanoparticles

“…Over the last two decades, the interest of NLC for delivery applications has steadily increased [ 12 , 13 ], largely due to their safe bioassimilable ingredients, their up-scalable fabrication process [ 14 ] and their long-term colloidal stability [ 8 , 11 ]. In the REFINE project, we have used a NLC that has demonstrated great promise for imaging purposes [ 15 , 16 ] and the delivery of active pharmaceutical ingredients [ 17 – 19 ]. This NLC platform was loaded with IR780-oleyl, a near-infrared (NIR) dye tailored for its efficient encapsulation in the particle lipid core, yielding LipImage ™ 815, a nano-imaging agent for in vivo near-infrared (NIR) fluorescence imaging [ 20 ].…”

“…This NLC platform was loaded with IR780-oleyl, a near-infrared (NIR) dye tailored for its efficient encapsulation in the particle lipid core, yielding LipImage ™ 815, a nano-imaging agent for in vivo near-infrared (NIR) fluorescence imaging [ 20 ]. These nanoparticles are based on ingredients approved for human use, have high biocompatibility, are produced free of toxic solvents and have undergone production scale-up [ 16 ]. They showed low cytotoxicity and a prolonged plasma circulation in mice and larger animals [ 15 , 20 , 21 ].…”

Development, formulation, and cellular mechanism of a lipophilic copper chelator for the treatment of Wilson’s disease

“…NLC have since then aroused high interest as drug delivery systems, and in particular for liver targeting (Kong et al, 2013;Liu et al, 2014), all the more that they can be formulated for the oral delivery route (Liu et al, 2014;Nasirizadeh and Malaekeh-Nikouei, 2020;Tan et al, 2020;Wang et al, 2015). Recently, a new generation of NLC based on FDA approved ingredients has been developed by our team and demonstrated great promise for imaging purposes (Sayag et al, 2016;Vigne et al, 2020), and the delivery of active pharmaceutical ingredients (Bayon et al, 2018;Michy et al, 2019;Tezgel et al, 2018). In particular, their biodistribution pattern evidenced important liver uptake and metabolization (Gauthier et al, 2021;Merian et al, 2013), underlining their potential as efficient nanocarriers for liver treatments.…”