Nanostructured lipid carrier system: A compendium of their formulation development approaches, optimization strategies by quality by design, and recent applications in drug delivery

Javed, Shamama; Mangla, Bharti; Almoshari, Yosif; Sultan, Muhammad H.; Ahsan, Waquar

doi:10.1515/ntrev-2022-0109

Cited by 26 publications

(14 citation statements)

References 216 publications

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“…When solid lipid is mixed with natural oil alone, it becomes saturated and generates a smaller particle size. Moreover, when solid lipid is mixed with isopropyl myristate and natural oil, the particle size is smaller than when using isopropyl myristate alone [ 55 , 56 ]. All formulas had a high zeta potential of more than −52 mV.…”

Section: Resultsmentioning

confidence: 99%

Natural Stabilizers and Nanostructured Lipid Carrier Entrapment for Photosensitive Compounds, Curcumin and Capsaicin

Jandang,

Ampasavate,

Kiattisin

2024

Pharmaceutics

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Capsaicin and curcumin, the active components of chili and turmeric, are prone to instability when exposed to light. Therefore, this research aimed to enhance the photostability of both extracts via the use of antioxidants, natural sunscreen, and nanostructured lipid carriers (NLCs). NLCs were chosen for this this study due to their advantages in terms of stability, drug loading capacity, occlusive effect, skin penetration, and controlled release. The photostability of each extract and extracts mixed with antioxidants, including grape seed extract, tea extract, and chlorogenic acid, were determined. Chlorogenic acid can enhance the photostability of capsaicin from 6.79 h to 16.50 h, while the photostability of curcumin increased from 9.63 h to 19.25 h. In addition, the use of natural sunscreen (sunflower oil) also increased the photostability of capsaicin and curcumin. The mixed extracts were then loaded into NLCs. The particle size of the formulation was 153.73 nm with a PDI value of 0.25. It exhibited high entrapment efficiency (more than 95%). In addition, it effectively reduced the decomposition of capsaicin and curcumin. Importantly, the natural stabilizers chosen for NLC fabrication significantly improved the photostability of curcumin and capsaicin by 600% and 567% compared to the unstabilized counterparts. This improvement contributes to the sustainability and bioavailability of these compounds in both cosmeceutical and pharmaceutical products.

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Section: Resultsmentioning

confidence: 99%

Natural Stabilizers and Nanostructured Lipid Carrier Entrapment for Photosensitive Compounds, Curcumin and Capsaicin

Jandang,

Ampasavate,

Kiattisin

2024

Pharmaceutics

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“…Ostwald ripening, drug leakage, and aggregation are stability problems that could jeopardize long-term storage. The manufacturing process is intricate, requiring specialized tools and knowledge to complete steps like high-pressure homogenization and microemulsion ( 72 ). Thorough safety evaluations are required because of concerns regarding the biocompatibility and possible toxicity of the lipids and surfactants utilized in NLC formulations.…”

Section: Classification Of Lbnpsmentioning

confidence: 99%

Lipid-based nanoparticles as drug delivery carriers for cancer therapy

Waheed,

Ali,

Tabassum

et al. 2024

Front. Oncol.

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Cancer is a severe disease that results in death in all countries of the world. A nano-based drug delivery approach is the best alternative, directly targeting cancer tumor cells with improved drug cellular uptake. Different types of nanoparticle-based drug carriers are advanced for the treatment of cancer, and to increase the therapeutic effectiveness and safety of cancer therapy, many substances have been looked into as drug carriers. Lipid-based nanoparticles (LBNPs) have significantly attracted interest recently. These natural biomolecules that alternate to other polymers are frequently recycled in medicine due to their amphipathic properties. Lipid nanoparticles typically provide a variety of benefits, including biocompatibility and biodegradability. This review covers different classes of LBNPs, including their characterization and different synthesis technologies. This review discusses the most significant advancements in lipid nanoparticle technology and their use in medicine administration. Moreover, the review also emphasized the applications of lipid nanoparticles that are used in different cancer treatment types.

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“…Using this method in the formulation of NLCs can increase drug loading capacity and stability when the medication exhibits higher solubility in oil. A solid lipid matrix contains evenly distributed tiny oil droplets, and this system is distributed in an aqueous medium [25] . Such type of NLC were shown below in Figure -8.…”

Section: Nlc Type I (Imperfect Nlcs)mentioning

confidence: 99%

Nanostructured Lipid Carrier for Hyperpigmentation Treatment - a Dermal Prospective

et al. 2024

IJFMR

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The normal human skin is exposed to different types of infection like wrinkles, pigmentation, acne, pimples in which pigmentation is most common in women over 30-40 years. The field of nanotechnology is currently intensely exploited for drug delivery technology for passive and active targeting via various routes of administration, such things can be effectively treated by incorporating the drug, loaded in a Nanostructured lipid carrier (NLC). NLCs have shown potential in delivering poorly soluble active components and in depigmenting. NLC springs up as the second generation of lipid nanoparticles to overcome the shortcomings of first generation through the topical route. NLC in topical administration provides some added advantages like increasing skin hydration and modified release profile and increase in skin penetration leading to avoidance of systemic absorption. NLCs are composed of biocompatible lipids, surfactants, and cosurfactants which help enhance drug loading capacity and stabilize the formulation. NLC's remarkable physicochemical and subsequently biocompatible qualities have created an ongoing need for the development of beneficial and safe drug delivery methods. The key attributes of NLC that make them a promising drug delivery system are ease of preparation, biocompatibility, the feasibility of scale-up, non-toxicity, improved drug loading, and stability Their ingredients have a special impact on the end product's physicochemical characteristics and efficacy. The present review aims to focus on the recent advancement in the preparation, characterization, and applications of NLC in treating hyperpigmentation.

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Nanostructured lipid carrier system: A compendium of their formulation development approaches, optimization strategies by quality by design, and recent applications in drug delivery

Cited by 26 publications

References 216 publications

Natural Stabilizers and Nanostructured Lipid Carrier Entrapment for Photosensitive Compounds, Curcumin and Capsaicin

Natural Stabilizers and Nanostructured Lipid Carrier Entrapment for Photosensitive Compounds, Curcumin and Capsaicin

Lipid-based nanoparticles as drug delivery carriers for cancer therapy

Nanostructured Lipid Carrier for Hyperpigmentation Treatment - a Dermal Prospective

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