Nanostructured lipid carrier co-delivering tacrolimus and TNF-α siRNA as an innovate approach to psoriasis

Viegas, Juliana Santos Rosa; Praça, Fabíola Silva Garcia; Caron, Angelo Luis; Suzuki, Isabella; Silvestrini, Ana Vitória Pupo; Medina, Wanessa Silva Garcia; Ciampo, José Orestes Del; Kravicz, Marcelo; Bentley, Maria Vitória Lopes Badra

doi:10.1007/s13346-020-00723-6

Cited by 50 publications

(22 citation statements)

References 73 publications

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“…Viegas et al recently showed the potential of NLCs for the combined delivery of siRNA directed against TNF and of the anti-psoriatic drug tacrolimus. The anti-psoriatic effect of this combination co-delivered with NLCs has been validated in vivo [44]. Despite their effectiveness to entrap hydrophobic API, the encapsulation of hydrophilic API in NLCs remains limited.…”

Section: Nanostructured Lipid Carriers (Nlcs)mentioning

confidence: 99%

Supramolecular and Macromolecular Matrix Nanocarriers for Drug Delivery in Inflammation-Associated Skin Diseases

et al. 2020

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Skin is our biggest organ. It interfaces our body with its environment. It is an efficient barrier to control the loss of water, the regulation of temperature, and infections by skin-resident and environmental pathogens. The barrier function of the skin is played by the stratum corneum (SC). It is a lipid barrier associating corneocytes (the terminally differentiated keratinocytes) and multilamellar lipid bilayers. This intricate association constitutes a very cohesive system, fully adapted to its role. One consequence of this efficient organization is the virtual impossibility for active pharmaceutical ingredients (API) to cross the SC to reach the inner layers of the skin after topical deposition. There are several ways to help a drug to cross the SC. Physical methods and chemical enhancers of permeation are a possibility. These are invasive and irritating methods. Vectorization of the drugs through nanocarriers is another way to circumvent the SC. This mini-review focuses on supramolecular and macromolecular matrices designed and implemented for skin permeation, excluding vesicular nanocarriers. Examples highlight the entrapment of anti-inflammatory API to treat inflammatory disorders of the skin.

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Section: Nanostructured Lipid Carriers (Nlcs)mentioning

confidence: 99%

Supramolecular and Macromolecular Matrix Nanocarriers for Drug Delivery in Inflammation-Associated Skin Diseases

et al. 2020

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“…They observed good physicochemical properties and promising permeation and retention profiles for topical application. Finally, in vivo studies showed synergic effect and a more preserved architecture of the tissue after tacrolimus and TNF-α siRNA co-delivery in the psoriasis model [ 149 ].…”

Section: Nlc Containing Natural Substances Against Skin Inflammationmentioning

confidence: 99%

Nanostructured Lipid Carriers for the Formulation of Topical Anti-Inflammatory Nanomedicines Based on Natural Substances

et al. 2021

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The main function of the skin is to protect the body from the external environment. However, the skin can undergo inflammatory processes, due to genetic, hormonal, or environmental factors. When the defense system is overloaded, there is an increase in pro-inflammatory mediators and reactive oxygen species (ROS), which results in skin disorders. Among the substances used to treat these inflammatory processes, many natural substances with anti-inflammatory and antioxidant properties are being studied: nature is yet an abundant source to obtain diverse pharmacological actives. The treatment of skin diseases is usually focused on topical application, as it reduces the risk of systemic side effects and prevents drug degradation by first-pass metabolism. Thus, the properties of drug delivery vehicles can facilitate or inhibit its permeation. Due to the hydrophobic nature of the skin, a promising strategy to improve dermal drug penetration is the use of lipid-based nanoparticles, such as nanostructured lipid carriers (NLC). Therefore, in this review, we present NLC as a tool to improve dermal administration of natural substances with anti-inflammatory properties.

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“…Another LNC, consisting of a glycerol stearate and oleic acid core coated with polyethylenimine (PEI), was reported to deliver a combination of tacrolimus and siRNA against TNF‐α through the skin. This system generated a synergistic effect by reducing the severity of psoriatic plaques in an imiquimod‐induced psoriasis mouse model compared to treatment with tacrolimus alone or TNF‐α siRNA‐loaded nanocarriers alone 141 …”

Section: Noninvasive Dermal Delivery Of Nucleic Acidsmentioning

confidence: 99%

Formulation‐based approaches for dermal delivery of vaccines and therapeutic nucleic acids: Recent advances and future perspectives

Sallam

Prakash

Kumbhojkar

et al. 2021

Bioengineering & Transla Med

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A growing variety of biological macromolecules are in development for use as active ingredients in topical therapies and vaccines. Dermal delivery of biomacromolecules offers several advantages compared to other delivery methods, including improved targetability, reduced systemic toxicity and decreased degradation of drugs. However, this route of delivery is hampered by the barrier function of the skin. Recently, a large body of research has been directed towards improving the delivery of macromolecules to the skin, ranging from nucleic acids to antigens, using noninvasive means. In this review, we discuss the latest formulation-based efforts to deliver antigens and nucleic acids for vaccination and treatment of skin diseases. We provide a perspective of their advantages, limitations and potential for clinical translation. The delivery platforms discussed in this review may provide formulation scientists and clinicians with a better vision of the alternatives for dermal delivery of biomacromolecules, which may facilitate the development of new patientfriendly prophylactic and therapeutic medicines.

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Nanostructured lipid carrier co-delivering tacrolimus and TNF-α siRNA as an innovate approach to psoriasis

Cited by 50 publications

References 73 publications

Supramolecular and Macromolecular Matrix Nanocarriers for Drug Delivery in Inflammation-Associated Skin Diseases

Supramolecular and Macromolecular Matrix Nanocarriers for Drug Delivery in Inflammation-Associated Skin Diseases

Nanostructured Lipid Carriers for the Formulation of Topical Anti-Inflammatory Nanomedicines Based on Natural Substances

Formulation‐based approaches for dermal delivery of vaccines and therapeutic nucleic acids: Recent advances and future perspectives

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