Nanostructured lipid base carrier for specific delivery of garlic oil through blood brain barrier against aggressiveness of glioma

Pop, Dana; Yostawonkul, Jakarwan; Chonniyom, Walailuk; Unger, Onuma; Sakulwech, Sakhiran; Sathornsumetee, Sith; Saengkrit, Nattika

doi:10.1016/j.jddst.2021.102651

Cited by 11 publications

(3 citation statements)

References 27 publications

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“…In the chemotherapy treatment of glioblastomas, temozolomide-loaded NLC resulted in tumour growth inhibition by 1.4 and 1.8 times that of temozolomide loaded in solid lipid nanoparticles (SLN), as shown in Table 3, and polymeric nanoparticles, respectively [70]. Similarly, the study from Dana, Yostawonkul [71] also showed that treatment of glioblastoma with garlic oil encapsulated in kernel palm oil compared to garlic oil alone showed a reduction in tumour cell viability of 11.9%, as compared to 90.2% with garlic oil alone [71]. In the treatment of epilepsy, carbamazepine delivery using nanostructured lipid carriers improved by 1.35-5 folds in comparison with dispersion and enhanced the accumulation in the brain through delivery across the BBB via NLC [72].…”

Section: Lipid Vehicles In Treating Brain-related Disordersmentioning

confidence: 87%

Oleaginous Microbial Lipids’ Potential in the Prevention and Treatment of Neurological Disorders

Alhattab,

Moorthy,

Patel

et al. 2024

Marine Drugs

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The products of oleaginous microbes, primarily lipids, have gained tremendous attention for their health benefits in food-based applications as supplements. However, this emerging biotechnology also offers a neuroprotective treatment/management potential for various diseases that are seldom discussed. Essential fatty acids, such as DHA, are known to make up the majority of brain phospholipid membranes and are integral to cognitive function, which forms an important defense against Alzheimer’s disease. Omega-3 polyunsaturated fatty acids have also been shown to reduce recurrent epilepsy seizures and have been used in brain cancer therapies. The ratio of omega-3 to omega-6 PUFAs is essential in maintaining physiological function. Furthermore, lipids have also been employed as an effective vehicle to deliver drugs for the treatment of diseases. Lipid nanoparticle technology, used in pharmaceuticals and cosmeceuticals, has recently emerged as a biocompatible, biodegradable, low-toxicity, and high-stability means for drug delivery to address the drawbacks associated with traditional medicine delivery methods. This review aims to highlight the dual benefit that lipids offer in maintaining good health for disease prevention and in the treatment of neurological diseases.

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Section: Lipid Vehicles In Treating Brain-related Disordersmentioning

confidence: 87%

Oleaginous Microbial Lipids’ Potential in the Prevention and Treatment of Neurological Disorders

Alhattab,

Moorthy,

Patel

et al. 2024

Marine Drugs

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“…Solid lipid nanoparticles (SLNs) [ 10 , 11 ] are gaining popularity among a wide variety of lipid particles due to their distinct safe lipid profiles, high drug loading, and better protection of the incorporated phyto-compounds from adverse biological conditions. The solid core releases therapeutics in a very controlled manner over a long period.…”

Section: Introductionmentioning

confidence: 99%

Folic Acid Functionalized Diallyl Trisulfide–Solid Lipid Nanoparticles for Targeting Triple Negative Breast Cancer

Roychowdhury

Bhuyan

et al. 2023

Molecules

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DATS (diallyl trisulfide), an anti-oxidant and cytotoxic chemical derived from the plant garlic, has been found to have potential therapeutic activity against triple-negative breast cancer (TNBC). Its hydrophobicity, short half-life, lack of target selectivity, and limited bioavailability at the tumor site limit its efficacy in treating TNBC. Overexpression of the Folate receptor on the surface of TNBC is a well-known target receptor for overcoming off-targeting, and lipid nanoparticles solve the limitations of limited bioavailability and short half-life. In order to overcome these constraints, we developed folic acid (FA)-conjugated DATS-SLNs in this research. The design of experiment (DoE) method was employed to optimize the FA-DATS-SLNs’ nanoformulation, which resulted in a particle size of 168.2 ± 3.78 nm and a DATS entrapment of 71.91 ± 6.27%. The similarity index between MCF-7 and MDA-MB-231 cell lines demonstrates that FA-DATS-SLNs are more therapeutically efficacious in the treatment of aggravating TNBC. Higher cellular internalization and efficient Bcl2 protein downregulation support the hypothesis that functionalization of the FA on the surface of DATS-SLNs improves anticancer efficacy when compared with DATS and DATS-SLNs. FA-functionalized DATS-SLNs have demonstrated to be a promising therapeutic strategy for TNBC management.

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“…Nanotechnology has enabled the development of a wide variety of platforms including inorganic nanoparticles (NPs), polymeric NPs, dendrimers, liposomes, micelles, and nanogels (NGs) to be used for brain drug delivery. ,− Many BBB traversing strategies based on nanotechnologies have been developed to improve the transportation efficiency of the nanomedicines across BBB. − On one hand, temporary destruction of BBB by ultrasound, − mechanical action, , or magnetic NP-mediated heat generation can be used for reversible BBB opening. However, the invasive BBB disruption also allows harmful agents to enter the CNS, likely causing irreversible damage to the CNS normal functions.…”

mentioning

confidence: 99%

Macrophage Membrane-Camouflaged Responsive Polymer Nanogels Enable Magnetic Resonance Imaging-Guided Chemotherapy/Chemodynamic Therapy of Orthotopic Glioma

Xiao

et al. 2021

ACS Nano

127

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Development of innovative nanomedicine formulations to traverse the blood–brain barrier (BBB) for effective theranostics of glioma remains a great challenge. Herein, we report the creation of macrophage membrane-camouflaged multifunctional polymer nanogels coloaded with manganese dioxide (MnO2) and cisplatin for magnetic resonance (MR) imaging-guided chemotherapy/chemodynamic therapy (CDT) of orthotopic glioma. Redox-responsive poly(N-vinylcaprolactam) (PVCL) nanogels (NGs) formed via precipitation polymerization were in situ loaded with MnO2 and physically encapsulated with cisplatin to have a mean size of 106.3 nm and coated with macrophage membranes to have a good colloidal stability. The generated hybrid NGs display dual pH- and redox-responsive cisplatin and Mn(II) release profiles and can deplete glutathione (GSH) rich in tumor microenvironment through reaction with disulfide-containing cross-linkers within the NGs and MnO2. The thus created Mn(II) enables enhanced CDT through a Fenton-like reaction and T 1-weighted MR imaging, while the loaded cisplatin not only exerts its chemotherapy effect but also promotes the reactive oxygen species generation to enhance the CDT efficacy. Importantly, the macrophage membrane coating rendered the hybrid NGs with prolonged blood circulation time and ability to traverse BBB for specific targeted chemotherapy/CDT of orthotopic glioma. Our study demonstrates a promising self-adaptive and cooperative NG-based nanomedicine platform for highly efficient theranostics of glioma, which may be extended to tackle other difficult cancer types.

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Nanostructured lipid base carrier for specific delivery of garlic oil through blood brain barrier against aggressiveness of glioma

Cited by 11 publications

References 27 publications

Oleaginous Microbial Lipids’ Potential in the Prevention and Treatment of Neurological Disorders

Oleaginous Microbial Lipids’ Potential in the Prevention and Treatment of Neurological Disorders

Folic Acid Functionalized Diallyl Trisulfide–Solid Lipid Nanoparticles for Targeting Triple Negative Breast Cancer

Macrophage Membrane-Camouflaged Responsive Polymer Nanogels Enable Magnetic Resonance Imaging-Guided Chemotherapy/Chemodynamic Therapy of Orthotopic Glioma

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