Nanostructured gold microelectrodes for extracellular recording from electrogenic cells

Brüggemann, Dorothea; Wolfrum, Bernhard; Maybeck, Vanessa; Mourzina, Yulia; Jansen, M.; Offenhäusser, Andreas

doi:10.1088/0957-4484/22/26/265104

Cited by 106 publications

(104 citation statements)

References 48 publications

(51 reference statements)

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“…The HL-1 cells generated spontaneous action potentials. The maximum cell signal amplitude recorded was 906 μV pp at a background noise of about 62 μV pp , which is comparable to reported values of HL-1 recordings using gold MEAs on polyimide substrates, 68 as well as advanced clean-room-fabricated cell interfaces such as nanocavity electrodes 91 and nanopillar electrodes 92 on ceramic substrates.…”

Section: Extracellular Recordings Using Pdms and Hydrogel Meassupporting

confidence: 83%

Printed microelectrode arrays on soft materials: from PDMS to hydrogels

et al. 2018

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Microelectrode arrays (MEAs) provide promising opportunities to study electrical signals in neuronal and cardiac cell networks, restore sensory function, or treat disorders of the nervous system. Nevertheless, most of the currently investigated devices rely on silicon or polymer materials, which neither physically mimic nor mechanically match the structure of living tissue, causing inflammatory response or loss of functionality. Here, we present a new method for developing soft MEAs as bioelectronic interfaces. The functional structures are directly deposited on PDMS-, agarose-, and gelatin-based substrates using ink-jet printing as a patterning tool. We demonstrate the versatility of this approach by printing high-resolution carbon MEAs on PDMS and hydrogels. The soft MEAs are used for in vitro extracellular recording of action potentials from cardiomyocyte-like HL-1 cells. Our results represent an important step toward the design of next-generation bioelectronic interfaces in a rapid prototyping approach.npj Flexible Electronics (2018) 2:15 ;

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Section: Extracellular Recordings Using Pdms and Hydrogel Meassupporting

confidence: 83%

Printed microelectrode arrays on soft materials: from PDMS to hydrogels

et al. 2018

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“…Nevertheless, the simple fabrication of low-impedance and high-spatial-resolution electrodes still remains an experimental challenge. Attempts to lower the impedance, including the use of advanced interface materials [16][17][18] and patterning of metal electrodes [19][20][21][22], have led to promising results. However, they often require sophisticated techniques of production or lack mechanical stability and longevity.…”

Section: Introductionmentioning

confidence: 99%

Frequency-dependent signal transfer at the interface between electrogenic cells and nanocavity electrodes

et al. 2012

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We present a model to describe the response of chip-based nanocavity sensors during extracellular recording of action potentials. These sensors feature microelectrodes which are embedded in liquid-filled cavities. They can be used for the highly localized detection of electrical signals on a chip. We calculate the sensor's impedance and simulate the propagation of action potentials. Subsequently we apply our findings to analyze cell-chip coupling properties. The results are compared to experimental data obtained from cardiomyocyte-like cells. We show that both the impedance and the modeled action potentials fit the experimental data well. Furthermore, we find evidence for a large seal resistance of cardiomyocytes on nanocavity sensors compared to conventional planar recording systems.

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“…Nanowire-AAO composite polarizers are attractive devices for infrared wavelengths. Recently anodic alumina also finds applications in electronics and optoelectronics [158,249,53], photonics [161,162,39,42,305], integration of living cells with electronics [76,77,20], cells culture and tissue engineering [252,130,109], and drug-releasing platforms [253].…”

Section: Applications Of Anodic Aluminum Oxidementioning

confidence: 99%

Nanoporous Anodic Aluminum Oxide: Fabrication, Characterization, and Applications

Stępniowski

Bojar

2015

Handbook of Nanoelectrochemistry

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Anodic aluminum oxide (AAO) consists of parallel pores arranged in a honeycomb-like array. Since a two-step self-organized approach in anodic alumina fabrication was invented, tremendous attention was paid to this material. Structural features of anodic alumina, like pore diameter, interpore distance, and nanoporous oxide thickness, can be fully controlled by operating conditions, including type, concentration and temperature of the electrolyte, applied voltage, and duration of the anodization process. Moreover, these operating conditions have also a major impact on the nanoporous array arrangement. Quantitative arrangement analysis methods employing fast Fourier transforms have been developed to assess the nanopores' arrangement. The most frequent application of the anodic aluminum oxide is a template-assisted fabrication of nanostructures. Templates made of the AAO are being successfully applied in fabrication of nanowires, nanotubes, and nanodots by using diversity of techniques, including electrochemical deposition, physical and chemical vapor deposition, sol-gel techniques, etc. Due to the size of obtained nanostructures, magnetic, electric, piezoelectric, luminescent, and catalytic properties of the deposited materials can be significantly improved. Thus, control of the nanopores' structural features and arrangement is crucial for AAO applications in nanotechnology.

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Nanostructured gold microelectrodes for extracellular recording from electrogenic cells

Cited by 106 publications

References 48 publications

Printed microelectrode arrays on soft materials: from PDMS to hydrogels

Printed microelectrode arrays on soft materials: from PDMS to hydrogels

Frequency-dependent signal transfer at the interface between electrogenic cells and nanocavity electrodes

Nanoporous Anodic Aluminum Oxide: Fabrication, Characterization, and Applications

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