Nanostructured electrospun nonwovens of poly(ε-caprolactone)/quaternized chitosan for potential biomedical applications

Abstract

Blend solutions of poly(ε-caprolactone) (PCL) and N-(2-hydroxy)-propyl-3-trimethylammonium chitosan chloride (QCh) were successfully electrospun. The weight ratio PCL/QCh ranged in the interval 95/5-70/30 while two QCh samples were used, namely QCh1 (DQ¯ = 47.3%; DPv¯ = 2218) and QCh2 (DQ¯ = 71.1%; DPv¯ = 1427). According to the characteristics of QCh derivative and to the QCh content on the resulting PCL/QCh nonwoven, the nanofibers displayed different average diameter (175 nm-415 nm), and the nonwovens exhibited variable porosity (57.0%-81.6%), swelling capacity (175%-425%) and water vapor transmission rate (1600 g m 24 h-2500 g m 24 h). The surface hydrophilicity of nonwovens increases with increasing QCh content, favoring fibroblast (HDFn) adhesion and spreading. Tensile tests revealed that the nonwovens present a good balance between elasticity and strength under both dry and hydrated state. Results indicate that the PCL/QCh electrospun nonwovens are new nanofibers-based biomaterials potentially useful as wound dressings.

Preparation and Characterization of Electrospun Double-layered Nanocomposites Membranes as a Carrier for Centella asiatica (L.)

“…Generally, when pathogenic microorganisms contaminate skin wounds, the immune system mobilizes its energy trying to suppress the invasion of these pathogens instead of focusing on the re-establishment of the native skin's structural and functional features [1,[4][5][6]. If infection occurs, was used as the main component of the first layer, due to its biocompatibility, desirable mechanical strength, and ability to act as a protective barrier [10,[28][29][30]. On the other hand, the second layer of Poly(vinyl alcohol) (PVA) and Chitosan-Sodium tripolyphosphate (CS-TPP) containing Centella asiatica (L.) (CA) was designed to be in direct contact with the injured skin and enhance the healing process [30,31].…”

Chitosan‐laponite nanocomposite scaffolds for wound dressing application

“…The addition of Lap to chitosan was used to prepare a three‐dimensional nanocomposite scaffold to promote the cellular attachment, spreading, and proliferation. Additionally, an appropriate pore size of the scaffolds is an important characteristic in regard to potential use of this material for wound dressing, since it could benefit the absorption of exudates from the wound surface and transfer of nutrients and oxygen to the cells (dos Santos et al, ). Thus, to study scaffolds based on chitosan and Lap to be applied as wound dressing, the prepared scaffolds were evaluated by their morphological, water absorption capacity, tensile properties, in vitro bioadhesion, antimicrobial activity, and cytotoxicity.…”

“…(Luo, Luo, Gelinsky, Huang, & Ruan, ; Osorio et al, ; Sudheesh Kumar et al, ). Chitosan and its derivatives have been widely used in the development of these new wound dressings due to their high biocompatibility, biodegradability, and low toxicity (Archana, Dutta, & Dutta, ; dos Santos et al, ). However, wound dressings based on pure chitosan present low mechanical properties and reduced processing capacity, limiting their application.…”

Nanocellulose: Recent advances and its prospects in environmental remediation

“…Chemical treatments are used to isolate cellulose fibres to generate nanocellulose. Existing chemical pretreatment techniques include acid hydrolysis [ 69 ], carboxylation [ 70 ], carboxymethylation [ 71 ], quaternization [ 72 ], sulphonation [ 73 ], ionic liquid [ 74 ], and solvent-assisted pretreatments [ 75 ].…”