Nanostructure-Mediated Drug Delivery

Tailored dendritic core-multishell nanocarriers for efficient dermal drug delivery: A systematic top-down approach from synthesis to preclinical testing

“…In recent years, polymeric nanoparticles composed of biocompatible and biodegradable polymers have received increasing attention as a modern approach for dermal drug delivery. Thanks to their synthetic nature, one is able to precisely tailor polymeric particles with efficient, site specific and environmentally controlled drug release, which alongside the use of biocompatible polymers, can greatly improve the safety profiles of such therapies [4][5][6][7][8].…”

Recent trends in the lipid‐based nanoencapsulation of antioxidants and their role in foods

“…10 While previous encapsulation methods employed to protect antioxidants in foods have proven successful, the encapsulation of antioxidants for delivery to the human body to help to combat disease is in the early stages of development. As with the delivery of drugs, the delivery of any bioactive to various sites within the body is directly affected by particle size, 11,12 and thus nanoencapsulation has the potential to enhance bioavailability, improve controlled release and enable precision targeting of the bioactive compounds to a greater extent than microencapsulation-type delivery systems. In accordance with this, the focus of the present review will be exclusively on nanoencapsulation systems.…”

The advantages of a novel CoQ10 delivery system in skin photo-protection

“…Recent studies have also reported that a nano drug delivery system is a new and potent drug transport pathway for the slow-release, special-targeting and efficient delivery of drugs (Hughes, 2005;Shah et al, 2007). Therefore, it was important and meaningful to study the skin penetration ability of CoQ10-NLC in vivo.…”

“…Nano-structured lipid carriers (NLC), most of which are lipidbased particles with a diameter usually less than 100 nm, are novel drug delivery systems with high substance solubility, stability, powerful skin penetration and low skin irritation (Hughes, 2005;Müller et al, 2007;Kotyla et al, 2008;Küchler et al, 2009). Recently, studies have reported that water-soluble lipid carrier formulations could be easily prepared with some poorly water-soluble drugs such as paclitaxel, dexamethasone and amiodarone (Xie et al, 2005;Beck et al, 2007;Lacoeuille et al, 2007).…”