Nanostructural point-contact sensors for diagnostics of carcinogenic strains of Helicobacter pylori

Kamarchuk, G. V.; Pospelov, А. P.; Harbuz, D. A.; Gudimenko, V.A.; Kamarchuk, L. V.; Zaika, A.S.; Pletnev, A. M.; Кравченко, А. В.

doi:10.26565/2075-3810-2017-38-07

Cited by 4 publications

(11 citation statements)

References 17 publications

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“…To measure the sensor response to the action of human breath gas, a specific measurement technique similar to the one used in medical studies was implemented [20,26]. Measurement of the temporal dependence of the sensor conductance was performed during the action of a given gaseous medium.…”

Section: Methodsmentioning

confidence: 99%

“…In the previously published works, we showed the high efficiency of point-contact gas sensors based on tetracyanoquinodimethane compounds in the studies of human breath gas aimed at differentiating among the various strains of Helicobacter pylori bacterium [19,20]. The sensors used in these works were selected from the manufactured batches of sensors according to a special procedure using the criteria described in [21].…”

Section: Introductionmentioning

confidence: 99%

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Surface morphology features of point contact gas sensors based on Cu-TCNQ compound

Harbuz

Pospelov

Gudimenko

et al. 2021

Molecular Crystals and Liquid Crystals

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The 7,7,8,8-tetracyanoquinodimethane (TCNQ) radical anion salt compound was used as the sensitive material of gas point contact sensors. The phase composition and surface morphology of the obtained sensor films were established. It was found correlation between surface morphology of the point-contact transducer and definite type of the sensor response curve observed under action of the human breath gas. If the sensor sample is formed from numerical crystals of the same or similar sizes having a uniform shape, similar to a shell, and clearly defined external borders it indicates to the creation of defect-free Yanson point contacts in the process of soft electrochemical synthesis. As a result, the surface of the sensor is a complex multistructure of a numerous number of Yanson point contacts, which generates a large output signal from the sensor in response to the action of the analyte. When crystals of Cu-TCNQ compound forming samples under investigation have lower density, large size, distorted and full of fractures boundaries, it prevents the formation of high-quality point contacts. These morphologic peculiarities are typical for samples with low level of response signal. In the case of extremely low density of Cu-TCNQ crystals observed in the sample surface the sample does not show any response to the action of the human breath gas.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Surface morphology features of point contact gas sensors based on Cu-TCNQ compound

Harbuz

Pospelov

Gudimenko

et al. 2021

Molecular Crystals and Liquid Crystals

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“…The breath profile was registered using point-contact sensor matrices based on tetracyanoquinodimethane (TCNQ) compounds [ 34 ] in accordance with the method we developed and verified in our earlier medical studies [ 11 , 35 ]. A point-contact sensor matrix is a structure consisting of a large number of mechanically stable Yanson point contacts.…”

Section: Methodsmentioning

confidence: 99%

“…The mesoscopic point-contact sensor matrix has a small integrated source of energy, which is manufactured with a special technique during the synthesis of this nanostructure. The production of the energy source and the matrix as a whole is based on electrochemical processes described previously [ 34 , 37 – 38 ]. The applied technology guaranteed high reliability and longevity to the sensor elements.…”

Section: Methodsmentioning

confidence: 99%

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Selective detection of complex gas mixtures using point contacts: concept, method and tools

Pospelov¹,

Belan²,

Harbuz³

et al. 2020

Beilstein J. Nanotechnol.

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Of all modern nanosensors using the principle of measuring variations in electric conductance, point-contact sensors stand out in having a number of original sensor properties not manifested by their analogues. The nontrivial nature of point-contact sensors is based on the unique properties of Yanson point contacts used as the sensing elements. The quantum properties of Yanson point contacts enable the solution of some of the problems that could not be solved using conventional sensors measuring conductance. In the present paper, we demonstrate this by showing the potential of quantum point-contact sensors to selectively detect components of a gas mixture in real time. To demonstrate the high efficiency of the proposed approach, we analyze the human breath, which is the most complex of the currently known natural gas mixtures with extremely low concentrations of its components. Point-contact sensors allow us to obtain a spectroscopic profile of the mixture. This profile contains information about the complete set of energy interactions occurring in the point contact/breath system when the breath constituents adsorb to and desorb from the surface of the point-contact conduction channel. With this information we can unambiguously characterize the analyzed system, since knowing the energy parameters is key to successfully identifying and modeling the physicochemical properties of various quantum objects. Using the point-contact spectroscopic profile of a complex gas mixture it is possible to get a functional dependence of the concentration of particular breath components on the amplitude of the sensor output signal. To demonstrate the feasibility of the proposed approach, we analyze the point-contact profiles from the breath of several patients and compare them with the concentrations of serotonin and cortisol in the body of each patient. The obtained results demonstrate that the proposed methodology allows one to get an effective calibration function for a non-invasive analysis of the level of serotonin and cortisol in the human body using the point-contact breath test. The present study indicates some necessary prerequisites for the design of fast detection methods using differential sensor analysis in real time, which can be implemented in various areas of science and technology, among which medicine is one of the most important.

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Noninvasive real-time breath test for controlling hormonal background of the human body: detection of serotonin and melatonin with quantum point-contact sensors

Kamarchuk¹,

Pospelov²,

Harbuz³

et al. 2021

J. Breath Res.

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Significant progress in development of noninvasive diagnostic tools based on breath analysis can be expected if one employs a real-time detection method based on finding a spectral breath profile which would contain some energy characteristics of the analyzed gas mixture. Using the fundamental energy parameters of a quantum system, it is possible to determine with a high accuracy its quantitative and qualitative composition. Among the most efficient tools to measure energy characteristics of quantum systems are sensors based on Yanson point contacts. This paper reports the results of serotonin and melatonin detection as an example of testing the human hormonal background with point-contact sensors, which have already demonstrated their high efficiency in detecting carcinogenic strains of Helicobacter pylori and selective detection of complex gas mixtures. When comparing the values of serotonin and melatonin with the characteristic parameters of the spectral profile of the exhaled breath of each patient, high correlation dependences of the concentration of serotonin and melatonin with a number of characteristic parameters of the response curve of the point-contact sensor were found. The performed correlation analysis was complemented with the regression analysis. As a result, empiric regression relations were proposed to realize in practice the new non-invasive breath test for evaluation of the human hormonal background. Registration of the patient’s breath profile using point-contact sensors makes it possible to easily monitor the dynamics of changes in the human hormonal background and perform a quantitative evaluation of serotonin and melatonin levels in the human body in real time without invasive interventions (blood collection) and expensive equipment or reagents.

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Nanostructural point-contact sensors for diagnostics of carcinogenic strains of Helicobacter pylori

Cited by 4 publications

References 17 publications

Surface morphology features of point contact gas sensors based on Cu-TCNQ compound

Surface morphology features of point contact gas sensors based on Cu-TCNQ compound

Selective detection of complex gas mixtures using point contacts: concept, method and tools

Noninvasive real-time breath test for controlling hormonal background of the human body: detection of serotonin and melatonin with quantum point-contact sensors

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