Nanosponge formulations as oxygen delivery systems

Cavalli, Roberta; Akhter, Ansari Khalid; Bisazza, Agnese; Giustetto, Pierangela; Trotta, Francesco; Vavia, Pradeep R.

doi:10.1016/j.ijpharm.2010.09.025

Cited by 117 publications

(72 citation statements)

References 7 publications

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“…The final properties of a CD-NS are strongly influenced by the nature of the cross-linker, the degree of cross-linking and the conditions of the synthesis reaction [21]. Several studies on the formulation and use of CD-NSs as nanocarriers have been conducted, showing that CD-NSs are a suitable delivery system for drugs, macromolecules and gases [22][23][24][25][26][27][28][29].…”

Section: L-dopa [(S)-2-amino-3-(34-dihydroxyphenyl)mentioning

confidence: 99%

Molecularly imprinted cyclodextrin nanosponges for the controlled delivery of L-DOPA: perspectives for the treatment of Parkinson’s disease

Trotta

Caldera

Cavalli

et al. 2016

Expert Opinion on Drug Delivery

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Section: L-dopa [(S)-2-amino-3-(34-dihydroxyphenyl)mentioning

confidence: 99%

Molecularly imprinted cyclodextrin nanosponges for the controlled delivery of L-DOPA: perspectives for the treatment of Parkinson’s disease

Trotta

Caldera

Cavalli

et al. 2016

Expert Opinion on Drug Delivery

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“…Thus, the mean hydrodynamic diameter and the polydispersity index of particles were calculated using the cumulated analysis after averaging of all the total measurements. [19] …”

Section: Zeta Potentialmentioning

confidence: 99%

“…NSs solubilize drug by possibly masking the hydrophobic groups of itraconazole, by increasing the wetting of the drug, and/or by decreasing the crystallinity of the drug. [19] In drug delivery Because of their nanoporous structure, NSs can advantageously carry water-insoluble drugs and/or agents (BCS Class-II drugs). These complexes can be used to increase the dissolution rate, solubility, and stability of drugs, to mask unpleasant flavors and to convert liquid substances to solids.…”

Section: Application Of Nssmentioning

confidence: 99%

Untitled

Pawar

2016

AJP

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The invention of nanosponges (NSs) has become a significant step toward overcoming the problems associated with conventional drug delivery. NS drug delivery system has emerged as one of the most promising fields in life science. These small sponges circulate around the body until they encounter the target site and stick on the surface and began to release the drug in a controlled and predictable manner which is more effective for a particular given dosage. The development of new colloidal carrier called NSs has the potential to solve these problems. Both lipophilic and hydrophilic drugs can be loaded in NSs. NS is a novel and emerging technology which offers controlled drug delivery for topical use. They can be crafted for targeting drugs to a specific site, prevent drug and protein degradation, and prolong the drug release in a controlled manner. NSs play a key role in targeting drug delivery in a controlled manner. In this review article, application of NSs, its preparation methods, and evaluation have been discussed.

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“…A potential solution for the lack of oxygen may be the use of composite oxygen-delivering scaffold materials, with peroxide salts as source of oxygen [2]. These materials should deliver oxygen to cells or tissue for a prolonged period of time such that implanted cells survive and contribute to tissue repair, but without interfering with angiogenesis, which is induced in hypoxic conditions [3][4][5][6][7]. Such composites should provide cell survival throughout the scaffold, thereby improving tissue restoration or repair.…”

Section: Introductionmentioning

confidence: 99%

Control of oxygen release from peroxides using polymers

Steg

Buizer

Woudstra

et al. 2015

J Mater Sci: Mater Med

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An important limitation in cell therapy for the regeneration of tissue is the initial lack of oxygen. After implantation of large 3D cell-seeded structures, cells die rather than contribute to tissue regenerating. Here we've tested oxygen-releasing materials to improve cell survival and growth after implantation. Calcium peroxide (CaO2) in a polymer matrix was used as source of oxygen. Two polymers were tested in order to slow down and extend the period of oxygen release, poly(D,L-lactic acid) and poly(lactic-co-glycolic acid). Compared to CaO2 particles, both releasing systems showed an initially higher and shorter oxygen release. Human mesenchymal stromal cells cultured on casted films of these oxygen-releasing composites required catalase to proliferate, indicating the production of cytotoxic hydrogen peroxide as intermediate. Poly(D,L-lactic acid) and poly(lactic-co-glycolic acid) are less suited for slowly oxygen-releasing materials. Catalase was able to reduce the cytotoxic effect of H2O2.

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Nanosponge formulations as oxygen delivery systems

Cited by 117 publications

References 7 publications

Molecularly imprinted cyclodextrin nanosponges for the controlled delivery of L-DOPA: perspectives for the treatment of Parkinson’s disease

Molecularly imprinted cyclodextrin nanosponges for the controlled delivery of L-DOPA: perspectives for the treatment of Parkinson’s disease

Untitled

Control of oxygen release from peroxides using polymers

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