Nanosphere size control by varying the ratio of poly(ester amide) block copolymer blends

Lima, Mariana R.N.; Devore, David I.; Kohn, Joachim

doi:10.1016/j.jcis.2022.03.144

Cited by 4 publications

(3 citation statements)

References 45 publications

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“…The discrepancy should be caused by the difference in the physical properties between the amphiphilic diblock copolymers and PS (the reference used for calculation) during GPC characterization. [ 51‐52 ] Therefore, the molecular weight determined by NMR should be more reliable.…”

Section: Resultsmentioning

confidence: 99%

Emission‐Tunable Nanofluorophores through Self‐assembly of Amphiphilic Block Copolymers: toward Application in Cell Imaging

Zhang

et al. 2023

Chin. J. Chem.

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Comprehensive Summary Nanofluorophores based on aggregation‐induced emission (AIE) dyes have recently received considerable attention because of their unique optical properties and biocompatibility. In this work, we report an emission‐tunable nanofluorophore constructed by the self‐assembly of an amphiphilic block copolymer (denoted by PTN). The diblock copolymer was synthesized by RAFT polymerization. A polyethylene glycol‐based trithiocarbonate was employed as the macromolecular chain transfer agent, and a near‐infrared emitting tetraphenylethylene derivative with a vinyl terminal group was designed as the monomer. The block copolymers self‐assembled in an aqueous solution to form nanospheres, which showed near‐infrared emission at approximately 720 nm with a significant Stokes shift of approximately 260 nm. Furthermore, nanofluorophores have excellent biocompatibility, photostability, and pH‐independent emission‐tunable properties, and were successfully applied to label HeLa cells for fluorescence imaging.

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Section: Resultsmentioning

confidence: 99%

Emission‐Tunable Nanofluorophores through Self‐assembly of Amphiphilic Block Copolymers: toward Application in Cell Imaging

Zhang

et al. 2023

Chin. J. Chem.

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“…The degree of polymerization estimated by gravimetric analysis was also elevated from 59 to 221 (Table 4, PVP 89 ‐ b ‐PVAc 59 to PVP 89 ‐ b ‐PVAc 221 ). Noteworthily, the molecular weight of block copolymers determined by GPC (Figure S15) may not be proper because the calibration using a polystyrene standard could not represent the behavior of both blocks in the mobile and stationary phase [ 50 ] and the formation of self‐assembled particles affects the hydrodynamic volume of polymeric sample in the mobile phase, [ 51 ] too. Therefore, we compared the particle size with the degree of polymerization rather than the molecular weight.…”

Section: Resultsmentioning

confidence: 99%

Versatile cobalt(Salen‐NEt₂) for aqueous cobalt‐mediated radical polymerization

Chang

Ping

et al. 2023

J Chinese Chemical Soc

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Cobalt-mediated radical polymerization (CMRP) has enabled the polymerization of a wide range of monomers with predictable molecular parameters and well-defined compositions and architectures. However, the synthesis of hydrophilic polymers by CMRP directly in the aqueous phase is still challenging. Herein, a handy cobalt complex was developed to perform CMRP of N-vinylpyrrolidone (NVP), 2-hydroxyethyl acrylate (HEA), and N,N-dimethylacrylamide (DMA) with linearly increased molecular weight, low polydispersity values, and smoothly shifted gel permeation chromatography (GPC) traces. The chain extensions of NVP, HEA, and DMA revealed the well chain-end fidelity for the synthesis of block copolymers. Moreover, the poly(N-vinylpyrrolidone)-block-poly(vinyl acetate) (PVP-b-PVAc) amphiphilic block copolymer colloidal solution was achieved directly in aqueous phase by cobalt-mediated radical polymerization-induced self-assembly (CMR-PISA), forming the nanoparticles consisting of a hydrophilic PVP corona and a hydrophobic PVAc core. This new mediator opens the opportunity for the synthesis of various hydrophilic (co)polymers in an environmentally friendly manner.

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“…In the double emulsion method, the hydrophilic drug is dissolved in a small amount of water, mostly containing a surfactant, which is subsequently added to a solution of PLGA, e.g., DCM. After stirring, the resulting water-in-oil emulsion is dispersed into a larger amount of water to obtain a water-in-oil-in-water emulsion [19,20].…”

Section: Introductionmentioning

confidence: 99%

Preparation, Characterization, and Biological Evaluation of a Hydrophilic Peptide Loaded on PEG-PLGA Nanoparticles

Marinelli

Ciulla²,

Ritsema³

et al. 2022

Pharmaceutics

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The encapsulation of peptides and proteins in nanosystems has been extensively investigated for masking unfavorable biopharmaceutical properties, including short half-life and poor permeation through biological membranes. Therefore, the aim of this work was to encapsulate a small antimicrobial hydrophilic peptide (H-Ser-Pro-Trp-Thr-NH2, FS10) in PEG-PLGA (polyethylene glycol-poly lactic acid-co-glycolic acid) nanoparticles (Nps) and thereby overcome the common limitations of hydrophilic drugs, which because they facilitate water absorption suffer from rapid degradation. FS10 is structurally related to the well-known RNAIII inhibiting peptide (RIP) and inhibits S. aureus biofilm formation. Various parameters, including different method (double emulsion and nanoprecipitation), pH of the aqueous phase and polymeric composition, were investigated to load FS10 into PEG-PLGA nanoparticles. The combination of different strategies resulted in an encapsulation efficiency of around 25% for both the double emulsion and the nanoprecipitation method. It was found that the most influential parameters were the pH—which tailors the peptides charge—and the polymeric composition. FS10-PEG-PLGA nanoparticles, obtained under optimized parameters, showed size lower than 180 nm with zeta potential values ranging from −11 to −21 mV. In vitro release studies showed that the Nps had an initial burst release of 48–63%, followed by a continuous drug release up to 21h, probably caused by the porous character of the Nps. Furthermore, transmission electron microscopy (TEM) analysis revealed particles with a spherical morphology and size of around 100 nm. Antimicrobial assay showed that the minimum inhibitory concentration (MIC) of the FS10-loaded Nps, against S. aureus strains, was lower (>128 µg/mL) than that of the free FS10 (>256 µg/mL). The main goal of this work was to develop polymeric drug delivery systems aiming at protecting the peptide from a fast degradation, thus improving its accumulation in the target site and increasing the drug-bacterial membrane interactions.

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Nanosphere size control by varying the ratio of poly(ester amide) block copolymer blends

Cited by 4 publications

References 45 publications

Emission‐Tunable Nanofluorophores through Self‐assembly of Amphiphilic Block Copolymers: toward Application in Cell Imaging

Emission‐Tunable Nanofluorophores through Self‐assembly of Amphiphilic Block Copolymers: toward Application in Cell Imaging

Versatile cobalt(Salen‐NEt₂) for aqueous cobalt‐mediated radical polymerization

Preparation, Characterization, and Biological Evaluation of a Hydrophilic Peptide Loaded on PEG-PLGA Nanoparticles

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Nanosphere size control by varying the ratio of poly(ester amide) block copolymer blends

Cited by 4 publications

References 45 publications

Emission‐Tunable Nanofluorophores through Self‐assembly of Amphiphilic Block Copolymers: toward Application in Cell Imaging

Emission‐Tunable Nanofluorophores through Self‐assembly of Amphiphilic Block Copolymers: toward Application in Cell Imaging

Versatile cobalt(Salen‐NEt2) for aqueous cobalt‐mediated radical polymerization

Preparation, Characterization, and Biological Evaluation of a Hydrophilic Peptide Loaded on PEG-PLGA Nanoparticles

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Versatile cobalt(Salen‐NEt₂) for aqueous cobalt‐mediated radical polymerization