Nanosphere and Microsphere-Based Drug Delivery Systems for Wound Healing Applications: A Review

Abstract

Chronic and acute wounds pose a huge burden on patients and health care systems. Early diagnosis and prompt treatment is essential in preventing further complications such as limb amputation and infection. Recent progress in our understanding of different wounds’ pathophysiology, has resulted in developing different drug delivery vehicles to target different phases of wound healing. During the past decade, microspheres and nanospheres have gained significant attention in drug delivering wound dressings. These vehicles have gained popularity largely due their biocompatibility, biodegradability, their high capacity to deliver various drug types, and long term sustained release profile. In the current review, we will discuss the challenges and prospects of microsphere and nanosphere-based drug delivery systems in wound healing.

Injectable Hydrogel Delivery System with High Drug Loading for Prolonging Local Anesthesia

“…They can encapsulate a large amount of water and other substances and achieve water-soluble drug release owing to their unique physicochemical properties and biocompatibility. [17][18][19][20][21] The main obstacle involving loading water-soluble drugs in hydrogel-based microspheres is how to prevent drug leakage due to the good swelling ability of hydrogel, which might reduce drug loading and increase the risk of drug burst release in vivo. Hence, a potential strategy to improve drug stability and long-term retention in vivo is to design a composite drug delivery system using drug-loaded hydrogel microspheres and hydrogels.…”