Nanosilver-functionalized polysaccharides as a platform for wound dressing

Mohan, Syam; Wal, Pranay; Pathak, Kamla; Khandai, Madhusmruti; Behl, Tapan; Alhazmi, Hassan A.; Khuwaja, Gulrana; Khalid, Asaad

doi:10.1007/s11356-023-26450-2

Cited by 2 publications

(2 citation statements)

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“…Silver nanoparticles release silver ions through an oxidation process, that occurs depending on various factors, such as the surface area, the concentration of oxygen in solution, and the dimensions: for the same quantity of silver, smaller nanoparticles have demonstrated increased activity [22]. Silver is a broad-spectrum antimicrobial agent, which uses various nonspecific mechanisms and is, therefore, suitable for overcoming the problem of antibiotic resistance.…”

Section: Introductionmentioning

confidence: 99%

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Rapid Prototyping of 3D-Printed AgNPs- and Nano-TiO2-Embedded Hydrogels as Novel Devices with Multiresponsive Antimicrobial Capability in Wound Healing

et al. 2023

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Two antimicrobial agents such as silver nanoparticles (AgNPs) and titanium dioxide (TiO2) have been formulated with natural polysaccharides (chitosan or alginate) to develop innovative inks for the rapid, customizable, and extremely accurate manufacturing of 3D-printed scaffolds useful as dressings in the treatment of infected skin wounds. Suitable chemical–physical properties for the applicability of these innovative devices were demonstrated through the evaluation of water content (88–93%), mechanical strength (Young’s modulus 0.23–0.6 MPa), elasticity, and morphology. The antimicrobial tests performed against Staphylococcus aureus and Pseudomonas aeruginosa demonstrated the antimicrobial activities against Gram+ and Gram− bacteria of AgNPs and TiO2 agents embedded in the chitosan (CH) or alginate (ALG) macroporous 3D hydrogels (AgNPs MIC starting from 5 µg/mL). The biocompatibility of chitosan was widely demonstrated using cell viability tests and was higher than that observed for alginate. Constructs containing AgNPs at 10 µg/mL concentration level did not significantly alter cell viability as well as the presence of titanium dioxide; cytotoxicity towards human fibroblasts was observed starting with an AgNPs concentration of 100 µg/mL. In conclusions, the 3D-printed dressings developed here are cheap, highly defined, easy to manufacture and further apply in personalized antimicrobial medicine applications.

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Section: Introductionmentioning

confidence: 99%

“…Toxicity is linked to the interaction of the Ag + ion with the thiol groups of membrane proteins and enzymes involved in cellular respiration, and with DNA; the result is the inhibition of cell proliferation. Toxicity is also due to a second mechanism, dependent on the type of cell: the formation of oxygen free radicals [22].…”

Section: Introductionmentioning

confidence: 99%