Nanosilver-DNA Hybrid Modified Electrode for Electrochemical Sensing of Buspirone in Biological Samples and Pharmaceutical Preparation

Daneshgar, Parandis; Ghaheri, Nazanin; Moosavi-Movahedi, Ali Akbar; Rezayat, Seyed Mehdi; Norouzi, Parviz; Ahmad, Faizan

doi:10.1166/sl.2012.2569

Cited by 2 publications

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“…A DNA-templated AgNP-based sensor for BUS was constructed [ 144 ] where the nanoparticles were deposited on the surface of a glassy carbon electrode by an electrochemical method in presence of DNA as a scaffold. The presence of DNA made the scaffold to arrange and order the nano-structures, which inhibited aggregation of silver nanoparticles and provided a better catalytic ability.…”

Section: Electrochemical Detection Of Drugs and Neurotransmitters Basmentioning

confidence: 99%

“…Better sensitivity for detection of BUS was obtained as a result, with a linear range of 2.0 – 70.0 nM and a detection limit of 1.1 nM. A polarographic method was reported [ 145 ] for analysis of BUS, which has an LOD of 0.52 nM, about two fold lower than the other electrode [ 144 ]. However, mercury is used here as an electrode material which is highly toxic and does not warrant good selectivity.…”

Section: Electrochemical Detection Of Drugs and Neurotransmitters Basmentioning

confidence: 99%

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Nanomaterial-based electrochemical sensing of neurological drugs and neurotransmitters

et al. 2014

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Nanomaterial-modified detection systems represent a chief driver towards the adoption of electrochemical methods, since nanomaterials enable functional tunability, ability to self-assemble, and novel electrical, optical and catalytic properties that emerge at this scale. This results in tremendous gains in terms of sensitivity, selectivity and versatility. We review the electrochemical methods and mechanisms that may be applied to the detection of neurological drugs. We focus on understanding how specific nano-sized modifiers may be applied to influence the electron transfer event to result in gains in sensitivity, selectivity and versatility of the detection system. This critical review is structured on the basis of the Anatomical Therapeutic Chemical (ATC) Classification System, specifically ATC Code N (neurotransmitters). Specific sections are dedicated to the widely used electrodes based on the carbon materials, supporting electrolytes, and on electrochemical detection paradigms for neurological drugs and neurotransmitters within the groups referred to as ATC codes N01 to N07. We finally discuss emerging trends and future challenges such as the development of strategies for simultaneous detection of multiple targets with high spatial and temporal resolutions, the integration of microfluidic strategies for selective and localized analyte pre-concentration, the real-time monitoring of neurotransmitter secretions from active cell cultures under electro- and chemotactic cues, aptamer-based biosensors, and the miniaturization of the sensing system for detection in small sample volumes and for enabling cost savings due to manufacturing scale-up. The Electronic Supporting Material (ESM) includes review articles dealing with the review topic in last 40 years, as well as key properties of the analytes, viz., pKa values, half-life of drugs and their electrochemical mechanisms. The ESM also defines analytical figures of merit of the drugs and neurotransmitters. The article contains 198 references in the main manuscript and 207 references in the Electronic Supporting Material.FigureᅟElectronic supplementary materialThe online version of this article (doi:10.1007/s00604-014-1308-4) contains supplementary material, which is available to authorized users.

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Section: Electrochemical Detection Of Drugs and Neurotransmitters Basmentioning

confidence: 99%

Section: Electrochemical Detection Of Drugs and Neurotransmitters Basmentioning

confidence: 99%

Nanomaterial-based electrochemical sensing of neurological drugs and neurotransmitters

et al. 2014

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A simple and sensitive electroanalytical determination of anxiolytic buspirone hydrochloride drug based on multiwalled carbon nanotubes modified electrode

2013

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Nanosilver-DNA Hybrid Modified Electrode for Electrochemical Sensing of Buspirone in Biological Samples and Pharmaceutical Preparation

Cited by 2 publications

References 0 publications

Nanomaterial-based electrochemical sensing of neurological drugs and neurotransmitters

Nanomaterial-based electrochemical sensing of neurological drugs and neurotransmitters

A simple and sensitive electroanalytical determination of anxiolytic buspirone hydrochloride drug based on multiwalled carbon nanotubes modified electrode

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