Nanosilver and Silver Nitrate Toxicity in Ex Vivo-Exposed Gills of Fish and Mitigation by Humic Acids

Ale, Analía; Galdopórpora, Juan Manuel; Desimone, Martín Federico; Torre, Fernando R. de la; Cazenave, Jimena

doi:10.1007/s00128-021-03257-w

Cited by 11 publications

(4 citation statements)

References 44 publications

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“…Our results showed that the presence of HA could reduce the accumulation of MPs in fish gills at the end of the depuration period. A recent study reported that Ag accumulation in the gills of the fish Corydoras paleatus decreased when HA was present in the media as compared to that with AgNP exposure alone (Ale et al, 2021), which was consistent with our study. According to the results of the stability experiment, HA adsorbed onto the MP surface could increase the stability of the MP suspensions.…”

Section: Accumulation Of Mps With Ha In Fish External Tissuessupporting

confidence: 93%

Influences of molecular weight fractionated humic acids on polyamide 66 microplastic stability and toxicity in red tilapia (Oreochromis niloticus)

Zheng

Ding

et al. 2022

Front. Mar. Sci.

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Dissolved organic matter (DOM) is likely to coexist with microplastics (MPs) in aquatic environments. However, little is known about the effects of different DOM fractions on the stability and aquatic toxicity of MPs. In this study, we separated humic acid (HA) into three molecular weight (MW) fractions (> 30, 3–30, and < 3 k Da) and examined their effects on the toxicity of polyamide 66 (PA66)-MPs to red tilapia (Oreochromis niloticus). Generally, addition of HA enhanced the stability and thus the exposure of tilapia to MPs, leading to the increased accumulation of MPs in the gut, liver, and brain. However, compared with MPs alone, the accumulation of MPs in the gills of tilapia was reduced. Compared with the presence of high-MW HA, the accumulation of MPs in the fish liver was significantly enhanced by 1.1 times in the presence of medium-MW HA (m-HA) after a 10-day exposure. The protein peroxidation on the liver induced by MPs was alleviated by adding all HA fractions. However, compared with MPs alone, the presence of m-HA resulted in a more severe lipid peroxidation, while the presence of low-MW HA alleviate the lipid peroxidation caused by MPs. In addition, the Integrated Biological Responses version 2 (IBRv2) results suggested that the oxidative stress in the liver tilapia caused by MPs could be alleviated by the presence of all HA fractions, which was largely related to the reduced damage caused by lipid peroxidation and/or protein peroxidation. Collectively, our results suggest that the presence of different MW HA fractions could induce complex changes in the MP toxicity on aquatic organisms.

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Section: Accumulation Of Mps With Ha In Fish External Tissuessupporting

confidence: 93%

Influences of molecular weight fractionated humic acids on polyamide 66 microplastic stability and toxicity in red tilapia (Oreochromis niloticus)

Zheng

Ding

et al. 2022

Front. Mar. Sci.

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“…In a UV‐Vis spectrum, metallic nanoparticles exhibit a characteristic surface plasmon resonance (SPR), and the absorption region for AgNPs SPR meanders from 350 to 700 nm 19 . In our sample, a peak at 409 nm was observed (Figure 1b), indicative of reduced Ag and that falls within the range characteristic of AgNPs, 20,21 and another peak at 232 nm that is attributed to silver nitrate 22,23 . prepared oligomer‐stabilized AgNPs and showed a typical SPR band of AgNPs with absorption maximum at 400 nm.…”

Section: Resultsmentioning

confidence: 64%

A crossover study of antimicrobial capacity and biotoxicity of silver nanoparticles

Sosa,

Igartúa,

Alonso

et al. 2024

Applied Organom Chemis

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Silver nanoparticles (AgNPs) have a primordial role in the nanotechnology industry since they have great antimicrobial effects against diverse pathogens. AgNP production, use, and discard have been increasing; still, there is debate about the consequences of exposure to AgNPs for animals and humans. The bioaccumulation and toxicity of AgNPs depend on several factors, including AgNP concentration, physicochemical characteristics, and aggregation. So, complete activity and toxicity profiles for each silver nanoparticle synthesized must be performed. The present work aimed to characterize the behavior of specific AgNPs, then crossover of their antimicrobial capacity against Pseudomonas aeruginosa and Staphylococcus aureus with their potential in vitro cytotoxic effects in murine fibroblasts (3T3) and human keratinocytes (HaCat) cell lines, and in vivo general and organ‐specific toxicity in zebrafish embryos and larvae. A high susceptibility of P. aeruginosa and S. aureus to low concentrations of AgNPs was observed, yet a cytotoxic effect was also detected in 3T3 and HaCat cells. Moreover, these concentrations delayed embryonic development in zebrafish embryos and presented morphological abnormalities, neurotoxicity, and cardiotoxicity in zebrafish larvae. The results highlight the importance of jointly evaluating the antimicrobial activity and the toxicological profile of each nanoparticle manufactured; this study presents a suitable platform for such crossover assessment.

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“…In addition, Kim et al (2013 ) demonstrated that the interaction of AgNPs with HA mitigated the mortality of Oryzias latipes embryos. On the other hand, Ale et al (2021a ) and Ale et al (2021b ) assessed the mitigation of HA on bioaccumulation and oxidative stress in the gills of Neotropical fish ( Piaractus mesopotamicus and Corydoras paleatus ) exposed ex vivo to AgNPs. P. mesopotamicus gills accumulated Ag almost six-fold lower when HA was present in the media.…”

Section: Aquatic Ecotoxicity Of Silver Nanoparticlesmentioning

confidence: 99%

Building the Bridge From Aquatic Nanotoxicology to Safety by Design Silver Nanoparticles

Corsi

Desimone

Cazenave

2022

Front. Bioeng. Biotechnol.

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Nanotechnologies have rapidly grown, and they are considered the new industrial revolution. However, the augmented production and wide applications of engineered nanomaterials (ENMs) and nanoparticles (NPs) inevitably lead to environmental exposure with consequences on human and environmental health. Engineered nanomaterial and nanoparticle (ENM/P) effects on humans and the environment are complex and largely depend on the interplay between their peculiar properties such as size, shape, coating, surface charge, and degree of agglomeration or aggregation and those of the receiving media/body. These rebounds on ENM/P safety and newly developed concepts such as the safety by design are gaining importance in the field of sustainable nanotechnologies. This article aims to review the critical characteristics of the ENM/Ps that need to be addressed in the safe by design process to develop ENM/Ps with the ablility to reduce/minimize any potential toxicological risks for living beings associated with their exposure. Specifically, we focused on silver nanoparticles (AgNPs) due to an increasing number of nanoproducts containing AgNPs, as well as an increasing knowledge about these nanomaterials (NMs) and their effects. We review the ecotoxicological effects documented on freshwater and marine species that demonstrate the importance of the relationship between the ENM/P design and their biological outcomes in terms of environmental safety.

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Nanosilver and Silver Nitrate Toxicity in Ex Vivo-Exposed Gills of Fish and Mitigation by Humic Acids

Cited by 11 publications

References 44 publications

Influences of molecular weight fractionated humic acids on polyamide 66 microplastic stability and toxicity in red tilapia (Oreochromis niloticus)

Influences of molecular weight fractionated humic acids on polyamide 66 microplastic stability and toxicity in red tilapia (Oreochromis niloticus)

A crossover study of antimicrobial capacity and biotoxicity of silver nanoparticles

Building the Bridge From Aquatic Nanotoxicology to Safety by Design Silver Nanoparticles

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