Nanoshell assisted laser soldering of vascular tissue

Schöni, Daniel; Bogni, Serge; Bregy, Amadé; Wirth, Amina; Raabe, Andreas; Vajtai, István; Pieles, Uwe; Reinert, Michael; Frenz, Martin

doi:10.1002/lsm.21140

Cited by 28 publications

(30 citation statements)

References 20 publications

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“…Furthermore, the flexibility of the scaffold is more favorable for vascular applications than solid solder films [58]. ssLAVW comprises the use of a polymeric scaffold to enhance cohesive bonding of the liquid solder during sLAVW [93][94][95][96][97][98][99][100][101][102][103]108]. A semi-porous scaffold composed of biocompatible polymeric material is drenched in chromophore-containing solder, placed over the coaptation, and irradiated.…”

Section: Drawbacks Of Slavwmentioning

confidence: 99%

“…In (B) ssLAVR was performed with a 50% BSA solder, poly(lactic-co-glycolic acid) (PLGA) scaffolds, and an 806-nm diode laser [102]. SsLAVR in (A) was performed on porcine carotid arteries [97], whereas in (B) ssLAVR was performed on porcine [102] and rabbit aortic strips [94,100]. The numbers in brackets indicate the reference from which the data were obtained.…”

Section: Laser-scaffold Interactionsmentioning

confidence: 99%

“…phore concentrations as a function of welding strength, respectively. The majority of ssLAVW studies were performed in vitro as ssLAVR of small-and medium-sized vessels and used either a 670-nm or an 806-810-nm diode laser [86,[93][94][95][96][97][98][99][100][101][102][103]. Figure 9 shows the improvement in welding strength with increasing power and irradiance.…”

Section: Laser-scaffold Interactionsmentioning

confidence: 99%

“…The non-presoaking technique, however, was associated with an increased risk of extensive thermal damage due to the distribution of heat to the vessel wall and the leakage of chromophore-containing solder through the coaptation [97,103]. The leakage and thermal damage issues can be circumvented by grafting chromophore-encapsulating nanoshells to the scaffold [100]. This recent technical advance in ssLAVR provides better control over heat deposition and eliminates the solder leakage-induced thermal damage.…”

Section: Laser-scaffold Interactionsmentioning

confidence: 99%

“…This modality homogeneously generates heat from inside the vessel wall, during which heat diffuses from the solder-tissue interface to the outer layer of the solder [59]. However, the internal irradiation is likely limited to small-sized vessels with a wall thickness of ≤ 0.3 mm [59,93,94,100]. In contrast to intraluminal irradiation, we believe that 360° external irradiation with e.g., several aiming beams attached to a clip probe could deliver simultaneous and uniform radiant energy and would be more applicable to all vessel sizes.…”

Section: Status Quo Of Sslavw and Possible Solutions 341 Improvemementioning

confidence: 99%

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Laser-assisted vessel welding: state of the art and future outlook

Pabittei

Boon

Heger

et al. 2015

JCTRes

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Laser-assisted vascular welding (LAVW) is an experimental technique being developed as an alternative to suture anastomosis. In comparison to mechanical anastomosis, LAVW is less traumatic, non-immunogenic, provides immediate water tight sealant, and possibly a faster and easier procedure for minimally invasive surgery. This review focuses on technical advances to improve welding strength and to reduce thermal damage in LAVW. In terms of welding strength, LAVW has evolved from the photothermally-induced microvascular anastomosis, requiring stay sutures to support welding strength, to sutureless anastomoses of medium-sized vessels, withstanding physiological and supraphysiological pressure. Further improvements in anastomotic strength could be achieved by the use of chromophore-containing albumin solder and the employment of (biocompatible) polymeric scaffolds. The anastomotic strength and the stability of welds achieved with such a modality, referred to as scaffold-and solder-enhanced LAVW (ssLAVW), are dependent on the intermolecular bonding of solder molecules (cohesive bonding) and the bonding between solder and tissue collagen (adhesive bonding). Presently, the challenges of ssLAVW include (1) obtaining an optimal balance between cohesive and adhesive bonding and (2) minimizing thermal damage. The modulation of thermodynamics during welding, the application of semi-solid solder, and the use of a scaffold that supports both cohesive and adhesive strength are essential to improve welding strength and to limit thermal damage.

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Section: Drawbacks Of Slavwmentioning

confidence: 99%

Section: Laser-scaffold Interactionsmentioning

confidence: 99%

Section: Laser-scaffold Interactionsmentioning

confidence: 99%

Section: Laser-scaffold Interactionsmentioning

confidence: 99%

Section: Status Quo Of Sslavw and Possible Solutions 341 Improvemementioning

confidence: 99%

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Laser-assisted vessel welding: state of the art and future outlook

Pabittei

Boon

Heger

et al. 2015

JCTRes

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Micro‐ and Nanostructured Biomaterials for Sutureless Tissue Repair

Frost

Mawad

Hook

et al. 2016

Adv Healthcare Materials

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Sutureless procedures for wound repair and closure have recently integrated nanostructured devices to improve their effectiveness and clinical outcome. This review highlights the major advances in gecko-inspired bioadhesives that relies mostly on van der Waals bonding forces. These are challenged by the moist environment of surgical settings that weaken adherence to tissue. The incorporation of nanoparticles in biomatrices and their role in tissue repair and drug delivery is also reviewed with an emphasis on procedures involving adhesives that are laser-activated. Nanostructured adhesive devices have the advantage of being minimally invasive to tissue, can seal wounds, and deliver drugs in situ. All these tasks are very difficult to accomplish by sutures or staples that are invasive to host organs and often cause scarring.

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Hybrid nanocomposite films for laser‐activated tissue bonding

Matteini

Ratto

Rossi

et al. 2012

Journal of Biophotonics

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We report new advancements in the biomedical exploitation of plasmonic nanoparticles as an effective platform for the photothermal repair of biological tissue. Chitosan films are loaded with gold nanorods with intense optical absorption in the "therapeutic window" of deepest light penetration through the body, and then activated by near infrared laser excitation to give adhesion with adjacent connective tissues. The adhesion consists of 0.07 mm(2) welds of ~20 kPa tensile strength at the film/tissue interface, which are obtained by administration of pulses with duration in the hundreds of millisecond timescale from a diode laser at ~130 J cm(-2). We investigate the adhesive effect as a function of pulse power and duration and identify an optimal operative window to achieve effective and reproducible welds with minimal detrimental superheating. These results may prove valuable to standardize laser bonding techniques and meet current needs for new knowledge which is urged by the penetration of nanotechnology into biomedical optics.

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Nanoshell assisted laser soldering of vascular tissue

Cited by 28 publications

References 20 publications

Laser-assisted vessel welding: state of the art and future outlook

Laser-assisted vessel welding: state of the art and future outlook

Micro‐ and Nanostructured Biomaterials for Sutureless Tissue Repair

Hybrid nanocomposite films for laser‐activated tissue bonding

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