Nanosensors for diagnosis with optical, electric and mechanical transducers

Munawar, Anam; Ong, Yori; Schirhagl, Romana; Tahir, Muhammad; Khan, Waheed S.; Bajwa, Sadia Z.

doi:10.1039/c8ra10144b

Cited by 114 publications

(56 citation statements)

References 105 publications

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“…Such nanosensors will be suitable for more sensitive biomarker detection in a large panel of diseases (e. g. cancer, CNS and infectious diseases). A review of Munawar et al gives a good overview of the potential of nanoparticles for nanosensors [ 30 ]. Typical applications of nanosensors are found in the monitoring and control of pandemics and plagues.…”

Section: Nanomedicine Is Not Only Focusing On Cancermentioning

confidence: 99%

Delivering the power of nanomedicine to patients today

Germain¹,

Caputo

Metcalfe

et al. 2020

Journal of Controlled Release

238

175

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The situation of the COVID-19 pandemic reminds us that we permanently need high-value flexible solutions to urgent clinical needs including simplified diagnostic technologies suitable for use in the field and for delivering targeted therapeutics. From our perspective nanotechnology is revealed as a vital resource for this, as a generic platform of technical solutions to tackle complex medical challenges. It is towards this perspective and focusing on nanomedicine that we take issue with Prof Park's recent editorial published in the Journal of Controlled Release. Prof. Park argued that in the last 15 years nanomedicine failed to deliver the promised innovative clinical solutions to the patients (Park, K. The beginning of the end of the nanomedicine hype. Journal of Controlled Release, 2019; 305, 221–222 [1]. We, the ETPN (European Technology Platform on Nanomedicine) [ 2 ], respectfully disagree. In fact, the more than 50 formulations currently in the market, and the recent approval of 3 key nanomedicine products (e. g. Onpattro, Hensify and Vyxeos), have demonstrated that the nanomedicine field is concretely able to design products that overcome critical barriers in conventional medicine in a unique manner, but also to deliver within the cells new drug-free therapeutic effects by using pure physical modes of action, and therefore make a difference in patients lives. Furthermore, the >400 nanomedicine formulations currently in clinical trials are expecting to bring novel clinical solutions (e.g. platforms for nucleic acid delivery), alone or in combination with other key enabling technologies to the market, including biotechnologies, microfluidics, advanced materials, biomaterials, smart systems, photonics, robotics, textiles, Big Data and ICT (information & communication technologies) more generally. However, we agree with Prof. Park that “ it is time to examine the sources of difficulty in clinical translation of nanomedicine and move forward “. But for reaching this goal, the investments to support clinical translation of promising nanomedicine formulations should increase, not decrease. As recently encouraged by EMA in its roadmap to 2025, we should create more unity through a common knowledge hub linking academia, industry, healthcare providers and hopefully policy makers to reduce the current fragmentation of the standardization and regulatory body landscape. We should also promote a strategy of cross-technology innovation, support nanomedicine development as a high value and low-cost solution to answer unmet medical needs and help the most promising innovative projects of the field to get better and faster to the clinic. This global vision is the one that the ETPN chose to encourage for the last fifteen years. All actions should be taken with a clear clinical view in mind, “ without any fanfare ”, to focus “ on what matters in real life ”, which is the patient and his/her quality of life....

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Section: Nanomedicine Is Not Only Focusing On Cancermentioning

confidence: 99%

Delivering the power of nanomedicine to patients today

Germain¹,

Caputo

Metcalfe

et al. 2020

Journal of Controlled Release

238

175

View full text Add to dashboard Cite

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“…In early 2000s, nanoelectromechanical systems (NEMS), a promising technology based on the MEMS has emerged to enable the fabrication of devices with at least one dimension smaller than 100 nm [ 147 ]. The continuous miniaturization of MEMS into the NEMS has allowed the development of nanodevices and nanosensors with new capabilities or improved performance, such as increases in resonance frequency and improvements in force, mass, and displacement sensitivity [ 148 ]. In 2002, Zorman and Mehregany presented an overview of the fabrication of SiC MEMS and NEMS structures in an interesting review [ 149 ].…”

Section: Device Application Of Cvd Sic Films: From Mems To Nemsmentioning

confidence: 99%

Progresses in Synthesis and Application of SiC Films: From CVD to ALD and from MEMS to NEMS

Fraga

Pessoa

2020

Micromachines

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A search of the recent literature reveals that there is a continuous growth of scientific publications on the development of chemical vapor deposition (CVD) processes for silicon carbide (SiC) films and their promising applications in micro- and nanoelectromechanical systems (MEMS/NEMS) devices. In recent years, considerable effort has been devoted to deposit high-quality SiC films on large areas enabling the low-cost fabrication methods of MEMS/NEMS sensors. The relatively high temperatures involved in CVD SiC growth are a drawback and studies have been made to develop low-temperature CVD processes. In this respect, atomic layer deposition (ALD), a modified CVD process promising for nanotechnology fabrication techniques, has attracted attention due to the deposition of thin films at low temperatures and additional benefits, such as excellent uniformity, conformability, good reproducibility, large area, and batch capability. This review article focuses on the recent advances in the strategies for the CVD of SiC films, with a special emphasis on low-temperature processes, as well as ALD. In addition, we summarize the applications of CVD SiC films in MEMS/NEMS devices and prospects for advancement of the CVD SiC technology.

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“…Ideally, those portable devices do not require specific skills and extensive training to use, since they are compact and user-friendly with simple functional requirements. Nanosensors bear recognition units which are able to capture molecules of interest, and this process triggers a clear signal, typically optical, electric, mechanical or acoustic in origin [64]. Nanosensors are not only widely considered to be the future of medical diagnostics, being able to recognise underlying health conditions before any symptoms appear, but are equally promising in other fields such as forensic toxicology and trace detection of explosives.…”

Section: Molecular Sensingmentioning

confidence: 99%

Carbon Dots for Forensic Applications: A Critical Review

Verhagen

Kelarakis

2020

Nanomaterials

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Owing to their superior fluorescence performance, inexpensive synthesis and nontoxic nature, carbon dots (C-dots) are systematically explored in a variety of applications; in this review, we outline and critically discuss recent trends with respect to their potential exploitation in criminal investigation, forensic toxicology and anti-counterfeit interventions. Capitalising on their colour-tuneable behaviour (in the sense that they adopt different colours with respect to the incident radiation), C-dot-based compositions are ideal for the visual enhancement of latent fingerprints, affording improved contrast against multicoloured and patterned backgrounds. As highly sensitive and highly selective optical nanoprobes, C-dots show excellent analytical performance in detecting biological compounds, drugs, explosives, heavy metals and poisonous reactants. In addition, benefiting from their versatile structural and chemical composition, C-dots can be incorporated into ink and polymeric formulations capable of functioning as a new generation of cost-effective barcodes and security nanotags for object authentication and anti-counterfeit applications. Translating these encouraging research outcomes into real-life innovations with significant social and economic impact requires an open, multidisciplinary approach and a close synergy between materials scientists, biologists, forensic investigators and digital engineers.

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Nanosensors for diagnosis with optical, electric and mechanical transducers

Abstract: Nanosensors with high sensitivity utilize electrical, optical, and acoustic properties to improve the detection limits of analytes.

Cited by 114 publications

References 105 publications

Delivering the power of nanomedicine to patients today

Delivering the power of nanomedicine to patients today

Progresses in Synthesis and Application of SiC Films: From CVD to ALD and from MEMS to NEMS

Carbon Dots for Forensic Applications: A Critical Review

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