Nanosensor networks for health-care applications

Yang, Jiancheng; Carey, Patrick H.; Ren, F.; Lobo, Brian C.; Gebhard, Michael; Leon, Marino E.; Lin, Jing-Fung; Pearton, S. J.

doi:10.1016/b978-0-12-819870-4.00023-2

Cited by 3 publications

(2 citation statements)

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“…Biomolecules range from proteins, aptamers, vitamins, and lipids to carbohydrates. − Inside proteins, biomarkers like cardiac troponins (cTn) have been used for biosensing toward the detection of acute myocardial infarction (AMI), a heart condition considered the main cause of death among ischemic heart diseases. − cTn contains three subunits: T, I, and C which interact with tropomyosin to conform the troponin–tropomyosin complex located on the actin filament. − Cardiac troponin I (cTnI) rises quickly from myocardial cells during the onset of symptoms and following cell death and gives the possibility of identifying signs of this condition . cTnI is composed of 10 amino acids, 4 essential and 6 nonessential, that are ordered in a specific alignment as shown in Figure .…”

Section: Introductionmentioning

confidence: 99%

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Energies Exploration for the Troponine Molecule Supported on Carbon Nanomaterials: DFT Study

Duque-Ossa

Reyes-Retana

2023

ACS Omega

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Density functional theory calculations have been used to elucidate structural parameters of pristine cardiac Troponin I and its interaction with carbon nanomaterials. In this case, zigzag single-walled carbon nanotubes and graphene sheets were selected. Troponin I interacted horizontally (leusine terminal) and vertically (lysine terminal) with the nanomaterials. Cohesion and binding energies, band gaps, and charge transfer for the systems were obtained. Cohesion for troponin I supported on graphene and single-walled carbon nanotube in the horizontal position was found to be the most viable system. Binding for the interaction between troponin I and a nanotube in the horizontal position was found to be the most stable with a value of 0.002 eV that increases to 0.004 eV with a van der Waals correction. Furthermore, the density of states exhibits an improvement in band gap for graphene sheets, and finally, a higher charge transfer was reported for troponin I in its horizontal form supported on a zigzag single-walled carbon nanotube.

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Section: Introductionmentioning

confidence: 99%

“… 23 − 27 Cardiac troponin I (cTnI) rises quickly from myocardial cells during the onset of symptoms and following cell death and gives the possibility of identifying signs of this condition. 28 cTnI is composed of 10 amino acids, 4 essential and 6 nonessential, that are ordered in a specific alignment as shown in Figure 1 .…”

Section: Introductionmentioning

confidence: 99%