Nanosecond-pulsed plasma jet in air and air/helium mixtures: Plasma properties and anticancer effect

Abstract

Nanosecond-pulse power has the characteristics of quickly increasing applied power, short pulse width, and considerably high-energy electrons. In this study, we investigated the different air/helium mixture ratios of nanosecond-pulsed-power-driven plasma jet discharge characteristics and the physicochemical properties of the gaseous and aqueous phases. Results showed that the length and luminescence intensity of the plasma increased with decreasing air ratio. Notably, there is a maximum inflection point in N2O5 of Fourier transform infrared spectrometry detection and concentration of H2O2 at 70% air ratio. Furthermore, we used drug-resistant ovarian cancer cells (A2780/ADR) as a model to detect the anticancer effect, with the results indicating that 70% air ratio is the best condition to inhibit cell growth and induce cell apoptosis. Our research indicates that the air discharge driven by a nanosecond-pulse power supply has potential application in an ovarian cancer drug-resistant tumor cell therapy.

Effects of DC bias on evolutions of repetitively pulsed streamer discharge in humid air

“…The subsequent primary streamer significantly follows previous secondary streamer trails in humid air. (3) The secondary streamer has more illuminating branches from the same root in humid air.…”

“…The pulse-periodic streamer discharge is an attractive and convenient method to generate low-temperature plasmas with significant advantages of high electron temperature, high chemically active particle yield [1,2], enabling novel applications in medical sterilization [3], flow control [4] and CH 4 conversion [5]. Characteristics of repetitively pulsed streamer discharges are inevitably affected by various environmental conditions [6][7][8], among which the air humidity is an important factor.…”

A comparative study on the spectral characteristics of nanosecond pulsed discharges in atmospheric He and a He+2.3%H2O mixture

“…In the past, low-temperature plasma discharges at atmo-spheric pressure have garnered more attention, due to their potential applications in the fields of medicine [1,2], agriculture [3], energy and environment [4,5]. This is attributed to the plasma properties that can be exploited as an effective source for the generation of reactive species.…”