The evolution of bubbles in water may be a critical process in many technologies or applications, including several manufacturing processes. Despite the previous work on cavitations and bubbles, the prior investigations in the literature are not sufficient about the effect of a micro-scale structure (such as a microhole sidewall) confinement on the bubble evolution and on the bubble-generated shock waves. In this paper, this effect has been studied using a physics-based model, which has been verified by comparing its predictions with experimental measurements in the literature on bubble evolutions in water without a micro-scale structure confinement. Under the investigated conditions, it has been found that due to the reflection of the shock waves by the microhole sidewall and the interactions among the bubble and the reflected waves, the peak pressure on the hole bottom wall surface has been significantly enhanced. It is good work in the future to study the implications of the discovery on related manufacturing processes and other applications, and how to intentionally utilize the pressure enhancement effect to benefit the related applications and manufacturing processes.