Nanoscience and nanotechnology in fabrication of scaffolds for tissue regeneration

Fattahi, Farnaz Sadat

doi:10.1007/s40089-020-00318-6

Cited by 2 publications

(1 citation statement)

References 283 publications

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“…Furthermore, it provides structural support, functions as an adhesive substrate, presents growth factors to its receptors, sequesters, stores growth factors, senses, and transduces mechanical signals. Also, the ECM is involved in regulating numerous cellular purposes for instance survival, adhesion, migration, proliferation, differentiation, and supporting cells for binding [22,23]. The ECM organizes large fibrillar 3-D nets composed of glycosaminoglycans (GAGs) and various types of proteins such as collagen, fibronectin, elastin, and laminin.…”

Section: Ecm Biopolymer Components For Tissue Regenerationmentioning

confidence: 99%

Emerging Fabrication Techniques for Engineering Extracellular Matrix Biomimetic Materials

Ebhodaghe¹,

Fattahi²,

Ndibe³

et al. 2021

Preprint

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There is need to address the challenges of organ shortage, through development of tissues and organs with alternatives to those of the allograft-kind. This illustrates the quest behind novel biofabrication strategies such as 3D bio-printing, which is necessary to create artificial multi-cellular tissues/organs. Several findings have been reported in this review. First, the role of ECM components in tissue regenerative medicine is presented. Different ECM components such as collagen, gelatin, elastin, fibronectin, laminins and glycosaminoglycans are concisely examined for their tissue regenerative medicine applications. Next, current state of research on extrusion-based 3D bio-printing techniques and their limitations are reviewed. For example, we show that cell viability is still a challenge with extrusion, while the use of natural polymers such as collagen in improving composites’ mechanical properties is limited. Lastly, we examine unresolved research questions necessary to advance the present state of research in the field.

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Section: Ecm Biopolymer Components For Tissue Regenerationmentioning

confidence: 99%

Emerging Fabrication Techniques for Engineering Extracellular Matrix Biomimetic Materials

Ebhodaghe¹,

Fattahi²,

Ndibe³

et al. 2021

Preprint

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Polyvinyl Alcohol Nanofibers Blends as Drug Delivery System in Tissue Regeneration

Barros Araújo,

da Silva Soares,

da Silva Lima

et al. 2023

CPD

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Background: Nanofibers have shown promising clinical results in the process of tissue regeneration since they provide a similar structure to the extracellular matrix of different tissues, high surface-to-volume ratio and porosity, flexibility, and gas permeation, offering topographical features that stimulate cell adhesion and proliferation. Electrospinning is one of the most used techniques for manufacturing nanomaterials due to its simplicity and low cost. Objective: In this review, we highlight the use of nanofibers produced with polyvinyl alcohol and polymeric associations (PVA/blends) as a matrix for release capable of modifying the pharmacokinetic profile of different active ingredients in the regeneration of connective, epithelial, muscular, and nervous tissues. Methods: Articles were selected by three independent reviewers by analyzing the databases, such as Web of Science, PubMed, Science Direct, and Google Scholar (last 10 years). Descriptors used were “nanofibers”, “poly (vinyl alcohol)”, “muscle tissue”, “connective tissue”, “epithelial tissue”, and “neural tissue engineering”. The guiding question was: How do different compositions of polyvinyl alcohol polymeric nanofibers modify the pharmacokinetics of active ingredients in different tissue regeneration processes? Results: The results demonstrated the versatility of the production of PVA nanofibers by solution blow technique with different actives (lipo/hydrophilic) and with pore sizes varying between 60 and 450 nm depending on the polymers used in the mixture, which influences the drug release that can be controlled for hours or days. The tissue regeneration showed better cellular organization and greater cell proliferation compared to the treatment with the control group, regardless of the tissue analyzed. Conclusion: We highlight that, among all blends, the combinations PVA/PCL and PVA/CS showed good compatibility and slow degradation, indicating their use in prolonged times of biodegradation, thus benefiting tissue regeneration in bone and cartilage connective tissues, acting as a physical barrier that results in guided regeneration, and preventing the invasion of cells from other tissues with increased proliferation rate.

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Nanoscience and nanotechnology in fabrication of scaffolds for tissue regeneration

Cited by 2 publications

References 283 publications

Emerging Fabrication Techniques for Engineering Extracellular Matrix Biomimetic Materials

Emerging Fabrication Techniques for Engineering Extracellular Matrix Biomimetic Materials

Polyvinyl Alcohol Nanofibers Blends as Drug Delivery System in Tissue Regeneration

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