Nanoscaled PAMAM Dendrimer Spacer Improved the Photothermal‒Photodynamic Treatment Efficiency of Photosensitizer‐Decorated Confeito‐Like Gold Nanoparticles for Cancer Therapy

Saw, Wen Shang; Anasamy, Theebaa; Anh, Thu Thi; Lee, Hong Boon; Chee, Chin Fei; İşçi, Ümit; Misran, Misni; Dumoulin, Fabienne; Wang, Chong; Kiew, Lik Voon; Imae, Toyoko; Chung, Lip Yong

doi:10.1002/mabi.202200130

Cited by 11 publications

(8 citation statements)

References 91 publications

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“…But we found that the lung exhibited stronger fluorescence for free TCPP compared to other organs. Chung et al reported a similar biodistribution pattern for free TCPP . These results were consistent with the in vivo imaging data obtained previously.…”

Section: Resultssupporting

confidence: 90%

Oxygen-Generating Organic/Inorganic Self-Assembled Nanocolloids for Tumor-Activated Dual-Model Imaging-Guided Photodynamic Therapy

Fu,

Jang,

Liu

et al. 2023

ACS Appl. Mater. Interfaces

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Tumor phototheranostics is usually compromised by the hypoxic tumor microenvironment and poor theranostic efficiency. The interplay between organic polymers and inorganic nanoparticles in novel nanocomposites has proven to be advantageous, overcoming previous limitations and harnessing their full potential through activation via the tumor microenvironment. This study successfully fabricated hypoxia-activated nanocolloids called HOISNDs through a process of self-assembly involving superparamagnetic iron oxide nanoparticles (SPIONs) and an organic polymer ligand called tetrakis(4-carboxyphenyl) porphyrin (TCPP)-engineered organic polymer ligand [methoxy poly(ethyleneglycol)-block-poly(dopamine-ethylenediamine-conjugated-4-nitrobenzyl chloroformate)-l-glutamate, mPEG-b-P(Dopa-EDA-co-NBCF)LG-TCPP)]. The SPIONs act as an oxygen generator to overcome the challenges posed by hypoxic tumors and enable the use of hypoxic-activatable MR/fluorescence dual-modal imaging-guided photodynamic therapy (PDT). The colloid stability of these HOISNDs proved to be exceptional in diverse biomimetic environments. Furthermore, they not only augment T2-weighted contrast capability as an MRI contrast agent but also function as an oxygen-producing device to amplify the generation and release of reactive oxygen species (ROS). The HOISNDs can significantly target to tumor sites through the enhanced permeability and retention (EPR) effect with prolonged blood circulation time and subsequently are effectively endocytosed into a hypoxic intracellular environment that “turn on” the imaging function and photodynamic activity. Moreover, HOISNDs possess the ability to effectively decompose naturally occurring H2O2 into oxygen (O2) within the tumor utilizing the Fenton reaction. This method can mitigate the impact of hypoxia on oxygen-dependent PDT. The outcomes of in vivo diagnostic and therapeutic evaluations indicated that HOISNDs are a highly promising tool for dual-model imaging-guided cancer theranosis by ameliorating hypoxic conditions and augmenting PDT efficiency.

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Section: Resultssupporting

confidence: 90%

Oxygen-Generating Organic/Inorganic Self-Assembled Nanocolloids for Tumor-Activated Dual-Model Imaging-Guided Photodynamic Therapy

Fu,

Jang,

Liu

et al. 2023

ACS Appl. Mater. Interfaces

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“…In another study, poly(amidoamine) dendrimers were utilized as spacers between the photosensitizers and gold NPs to provide nanosystems with high phototoxicity toward breast cancerous cell lines including MCF7, 4T1, and MDA-MB-231 (in vitro), showing suitable photothermal/photodynamic combinational therapeutic efficiency. Both in vitro and in vivo studies confirmed the efficacy of these nanosystems for accelerating the cellular uptake, plasmon-boosted singlet oxygen, and heat production …”

Section: Advanced Nanosystems For Targeted Cancer Therapeuticsmentioning

confidence: 68%

“…Both in vitro and in vivo studies confirmed the efficacy of these nanosystems for accelerating the cellular uptake, plasmon-boosted singlet oxygen, and heat production. 77 2.1.3. Monoclonal Antibodies (mAbs) NPs.…”

Section: Advanced Nanosystems For Targeted Cancer Therapeuticsmentioning

confidence: 99%

Advanced Nanosystems for Cancer Therapeutics: A Review

Mohajer

Mirhosseini‐Eshkevari

Ahmadi

et al. 2023

ACS Appl. Nano Mater.

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Since cancer has a very complex pathophysiology, existing cancer treatment strategies encounter several challenges such as the lack of specificity/selectivity, induction of multidrug resistance, and possible side effects/toxicity. A wide variety of organic, inorganic, and hybrid nanosystems have been designed with unique magnetic, thermal, mechanical, electrical, and optical properties for targeted cancer therapy. These advanced nanosystems with enhanced bioavailability, biocompatibility, and drug loading capacity have been developed for targeted cancer therapy to reduce toxicity and improve the targeting properties. In this context, challenges persist for their clinical translational studies and enhancement of their therapeutic efficiency as well as the optimization of synthesis conditions and large-scale production. In addition, despite promising preclinical results, the number of nanosystems available to patients is still very low, partly due to a lack of understanding of the differences among animal model species and humans that influence the behavior and functionality of these nanosystems. Regarding this, organ-on-a-chip platforms can significantly help in drug screening and delivery aspects in cancer/tumor cells as well as cancer modeling research; the organs-on-chip approach can also be helpful to analyze the cancer–immune cells interactions. Future studies should focus on the exploration of multifunctional nanosystems with synergistic chemo-photothermal, photothermal/photodynamic, and cancer immunotherapeutic potentials as well as smart nanosystems with theranostic capabilities. Herein, recent advancements pertaining to the applications of advanced nanosystems for cancer therapeutics are deliberated. Current obstacles and limitations hindering the application from research to clinical uses are also discussed while providing recommendations for a more efficient adoption of nanomaterials in the treatment of cancers.

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“…The photothermal therapeutic properties of these nanocomposites could be realized via irradiation of an external light source. [109] Furthermore, other photosensitizers could also be loaded into dendrimers in order to achieve their higher accumulation in tumor cells and efficient release of ROS, which would be precise, safe, and effective means of treatment and remarkably enhance the therapeutic effect of PDT. [110] PDT has become a burgeoning cancer treatment modality with considerable advantages, including minimal side effects, least drug resistance, and negligible systemic toxicity.…”

Section: Dendrimer Conjugates To Enhance Photodynamic Therapymentioning

confidence: 99%

Polymeric Dendrimers as Nanocarrier Vectors for Neurotheranostics

Zha

Liu

et al. 2022

Small

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immune responses, activating cellular machinery causing cell stress, cytotoxicity, lack of selectivity, increasing the likelihood of replication competence, and the constrained structure of insert-size, which can limit their biological and medical applications. [2][3][4] By contrast, various forms of nonviral vectors are widely developed and applied in biomedical research because of their low immunogenicity, high biocompatibility, simplicity in structural pattern, ease of size adjustment, practicality in designing various active sites, and low cost of production. [5,6] The most widely studied nonviral vectors are liposomes, inorganic nanoparticles, polymers, and dendrimers. [7] Liposomes are small spherical vesicles from cholesterol and phospholipids characterized with the surface that can be modified using glycolipids or sialic acid. Yet, the unmodified forms of liposomes are structurally unstable and could easily be eliminated by means of body circulation. [8] In this situation, stable inorganic nanoparticles, such as calcium phosphate (Ca 3 (PO 4 ) 2 ), gold (Au), iron oxide (Fe 3 O 4 ), and lanthanide-based nanoparticles are widely used, mainly due to their good hydrophilicity and excellent biocompatibility. [9][10][11] Depending on their chemical core composition, these inorganic nanoparticles display different properties and efficiencies. Lately, inorganic nanoparticles have been developed as effective drug delivery systems and used in many diagnostic techniques. [12] In addition, polymers are widely used as nonviral vectors as well. [13][14][15] Polymers are biodegradable nanomaterials with stable and easily modifiable 3D structures. Their uncomplicated synthesis process allows for large-scale production and safe clinical use compared to inorganic nanoparticles. [16] Notably, dendrimers are hyperbranched polymers with a well-defined chemical structure: a core at the center occupied by array of convergent reactive chain-ends and surface that can easily be modified. [17] The chemistry of dendrimers was first described by Buhleier et al. in 1978. [18] In 1985, Tomalia et al. reported a newer kind of dendrimers based on the mixture of amines and amides, termed polyamidoamine (PAMAM) dendrimers. [19] Dendrimers are intermeshed synthetic organic macromolecules with 3D architecture composition and abundant terminal functional groups. They are well-defined monodispersity-sized materials with extraordinary membrane interaction properties Dendrimers are polymers with well-defined 3D branched structures that are vastly utilized in various neurotheranostics and biomedical applications, particularly as nanocarrier vectors. Imaging agents can be loaded into dendrimers to improve the accuracy of diagnostic imaging processes. Likewise, combining pharmaceutical agents and anticancer drugs with dendrimers can enhance their solubility, biocompatibility, and efficiency. Practically, by modifying ligands on the surface of dendrimers, effective therapeutic and diagnostic platforms can be constructed and implemented for target...

show abstract

Nanoscaled PAMAM Dendrimer Spacer Improved the Photothermal‒Photodynamic Treatment Efficiency of Photosensitizer‐Decorated Confeito‐Like Gold Nanoparticles for Cancer Therapy

Cited by 11 publications

References 91 publications

Oxygen-Generating Organic/Inorganic Self-Assembled Nanocolloids for Tumor-Activated Dual-Model Imaging-Guided Photodynamic Therapy

Oxygen-Generating Organic/Inorganic Self-Assembled Nanocolloids for Tumor-Activated Dual-Model Imaging-Guided Photodynamic Therapy

Advanced Nanosystems for Cancer Therapeutics: A Review

Polymeric Dendrimers as Nanocarrier Vectors for Neurotheranostics

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