Nanoscaled biocompatible magnetic drug-delivery system: preparation and characterization

Abstract

Biocompatible magnetic nanocomposite consisting of bovine serum albumin-based nanosized spheres hosting maghemite nanoparticle has been investigated by Mössbauer spectroscopy, X-ray diffraction, and electron microscopy. The 77 K Mössbauer spectrum was curve-fitted to two sextets whereas one doublet plus one sextet was used to fit the 300 K Mössbauer spectrum. The temperature evolution of the hyperfine parameters indicated two Mössbauer components; one associated to the core maghemite nanoparticle and the other associated to the maghemite surface shell. The 300 K quadrupole splitting value indicated strong interaction between the surface of the maghemite nanoparticle and the hosting template.

Magnetic Properties of R-YIG (R = La, Nd, and Gd) Derived by a Sol-gel Method

“…Recently, Neel's relaxation at submicron sized Gd-YIG was reported [15]. The different distribution of the surface atoms on the powder affect to quadrupole splitting at and below 13 K. It easily disappeared as increasing measuring temperature [18]. The spin rotation relative with particle size may affect to quadrupole splitting [19].…”

Mechanistic and energetic studies of superparamagnetic iron oxide nanoparticles as a cyclophosphamide anticancer drug nanocarrier: A quantum mechanical approach

“…The possibility of targeted drug delivery causes reduction of the amount of drugs consumed and consequently the reduction of their side effects. 31–33 This superparamagnetism, exclusive to nanoparticles, is very valuable for their application as a drug delivery vehicle because they can actually drag drug molecules to their target site in the body under the impact of an external magnetic field. 34–36…”