Nanoscale vibration could promote tenogenic differentiation of umbilical cord mesenchymal stem cells

Karimi, Ebrahim; Vahedi, Negin; Sarbandi, Reza Ramezani; Parandakh, Azim; Ganjoury, Camellia; Sigaroodi, Faraz; Najmoddin, Najmeh; Tabatabaei, Mohammad; Tafazzoli-Shadpour, Mohammad; Ardeshirylajimi, Abdolreza; Khani, Mohammad‐Mehdi

doi:10.1007/s11626-023-00780-4

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Mechanotransduction Stimulation1

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2024

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“…Stem cells were grown on two-dimensional (2D) cell culture plates that were connected to piezoceramic systems. The results showed that nanovibration increased the expression of genes that encode tendon-related proteins, indicating that MSC mechanoregulation can be used in regenerative medicine [178].…”

Section: Mechanotransduction Stimulationmentioning

confidence: 99%

Recent Advances in the Use of Stem Cells in Tissue Engineering and Adjunct Therapies for Tendon Reconstruction and Future Perspectives

Dec,

Żyłka,

Burszewski

et al. 2024

IJMS

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Due to their function, tendons are exposed to acute injuries. This type of damage to the musculoskeletal system represents a challenge for clinicians when natural regeneration and treatment methods do not produce the expected results. Currently, treatment is long and associated with long-term complications. In this review, we discuss the use of stem cells in the treatment of tendons, including how to induce appropriate cell differentiation based on gene therapy, growth factors, tissue engineering, proteins involved in regenerative process, drugs and three-dimensional (3D) structures. A multidirectional approach as well as the incorporation of novel components of the therapy will improve the techniques used and benefit patients with tendon injuries in the future.

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Section: Mechanotransduction Stimulationmentioning

confidence: 99%