Nanoscale thickness double-gated field effect silicon sensors for sensitive pH detection in fluid

Elibol, Oğuz H.; Reddy, Bobby; Bashir, Rashid

doi:10.1063/1.2920776

Cited by 26 publications

(27 citation statements)

References 14 publications

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“…Here, we show that this device works like a double-gate organic thin-film transistor (DG OTFT), which is one of the classical transducer configurations for biosensing devices [20]. In a double-gate transistor, one of the two gates is the conventional bottom-gate and one is the additional top-gate.…”

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confidence: 99%

An Electrochemical Transducer Based on a Pentacene Double‐Gate Thin‐Film Transistor

2012

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We report an electrochemical transducer based on an organic double-gate transistor. The bottom-gate is given by a p-doped silicon substrate, which is covered by 300 nm thermal oxide. A 20 nm pentacene film acts as the semiconducting layer, and a 50 nm tetratetracontane (TTC) alkane film is used as a top-gate dielectric. An aqueous ionic solution acts as top-gate. We record the transistor transfer characteristics by variation of the electrolyte potential via a Ag/AgCl electrode for various bottom-gate settings. A change of the electrolyte potential results in a change of the transistor current and the characteristic behaviour of the device is in good agreement with the expected behaviour of a double-gate transistor. The top-gate capacitance of the alkane layer is as high as 2.6 10 À8 F cm À2 determined by impedance measurements, indicating that TTC is a good choice as an organic top-gate dielectric. The suitability of this transducer configuration for sensing in aqueous media is demonstrated by the detection of hexanoic acid and stearic acid molecules adsorbing to the alkane interface, respectively. We show that the transducer easily achieves a concentration sensitivity in the range of 100 nM.

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confidence: 99%

An Electrochemical Transducer Based on a Pentacene Double‐Gate Thin‐Film Transistor

2012

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“…Silicon field-effect devices were fabricated in our lab using SOI wafers and a VLSI-compatible process [63,64]. Colloidal Au nanoparticles (Au-NPs) of 5-nm mean diameter were purchased from Sigma and used as received.…”

Section: Methodsmentioning

confidence: 99%

“…Here, we demonstrate the applicability and versatility of monoalkoxysilylation chemistry to biosensors. We have constructed silicon field effect devices based upon silicon-on-insulator (SOI) technology in our lab [63,64] with 30-nm silicon thickness, 2-mm device width, and 20-mm device length. A bright-field top-view micrograph of a device is displayed in Figure 6 (top left).…”

Section: Full Papermentioning

confidence: 99%

Vapor‐Phase Deposition of Monofunctional Alkoxysilanes for Sub‐Nanometer‐Level Biointerfacing on Silicon Oxide Surfaces

Dorvel

Reddy

Block

et al. 2009

Adv Funct Materials

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Improving the performance and lowering the analyte detection limits of optical and electronic biosensors is essential for advancing wide ranging applications in diagnostics and drug discovery. Most sensing methods require direct linkage of a recognition element and a sensor, which is commonly accomplished through an organic monolayer interface. Alkoxyorganosilanes are typically used to prepare sensor surfaces on dielectric oxides. However, many silanes lead to roughened or thick interfaces that degrade device sensitivity. Here, controlled vapor phase deposition of monoalkoxysilanes is found to lead to monolayers resistant to elevated temperatures and extreme pH conditions. The formation of high density, subnanometer monolayers is demonstrated by ellipsometry, XPS, and AFM. The uniform attachment of these monofunctional silanes to such biosensing platforms as microarrays, field effect devices, and the formation of surface enhanced Raman spectroscopy substrates is demonstrated. The advantages of using this silane deposition protocol for the above technologies are also discussed.

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“…Further advances of these technologies require the ability to integrate additional elements, such as the miniaturized heating element described here, and the ability to integrate heating elements in a massively parallel format compatible with silicon technology (26). Notably, our miniaturized heaters could also function as dual heater/sensor elements, as these SOI nanowire or nanoribbon structures have been used to detect DNA, proteins, pH, and pyrophosphates (27)(28)(29)(30)(31).…”

Section: Discussionmentioning

confidence: 99%

Ultralocalized thermal reactions in subnanoliter droplets-in-air

Salm

Guevara

Dak

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

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Miniaturized laboratory-on-chip systems promise rapid, sensitive, and multiplexed detection of biological samples for medical diagnostics, drug discovery, and high-throughput screening. Within miniaturized laboratory-on-chips, static and dynamic droplets of fluids in different immiscible media have been used as individual vessels to perform biochemical reactions and confine the products. Approaches to perform localized heating of these individual subnanoliter droplets can allow for new applications that require parallel, time-, and spacemultiplex reactions on a single integrated circuit. Our method positions droplets on an array of individual silicon microwave heaters on chip to precisely control the temperature of droplets-in-air, allowing us to perform biochemical reactions, including DNA melting and detection of single base mismatches. We also demonstrate that ssDNA probe molecules can be placed on heaters in solution, dried, and then rehydrated by ssDNA target molecules in droplets for hybridization and detection. This platform enables many applications in droplets including hybridization of low copy number DNA molecules, lysing of single cells, interrogation of ligand-receptor interactions, and rapid temperature cycling for amplification of DNA molecules.nanowire | on-chip heating | evaporation

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Nanoscale thickness double-gated field effect silicon sensors for sensitive pH detection in fluid

Cited by 26 publications

References 14 publications

An Electrochemical Transducer Based on a Pentacene Double‐Gate Thin‐Film Transistor

An Electrochemical Transducer Based on a Pentacene Double‐Gate Thin‐Film Transistor

Vapor‐Phase Deposition of Monofunctional Alkoxysilanes for Sub‐Nanometer‐Level Biointerfacing on Silicon Oxide Surfaces

Ultralocalized thermal reactions in subnanoliter droplets-in-air

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