Nanoscale Thermal Phenomena in the Vicinity of Magnetic Nanoparticles in Alternating Magnetic Fields

Chiu‐Lam, Andreina; Rinaldi, Carlos

doi:10.1002/adfm.201505256

Cited by 66 publications

(66 citation statements)

References 74 publications

(128 reference statements)

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“…Despite the arguments against nanoscale thermal phenomena, experimental evidence highlights the benefits of heating effects in the vicinity of magnetic nanoparticles, which could actually enhance the thermal potentiation of chemotherapeutic agents. 3,49 Second, the mechanism of action of PES to induce cancer cell death can be further enhanced by one of the mechanisms triggered by MFH. PES inhibits the function of stress-inducible heat-shock proteins (HSP70 family), which support lysosome membrane integrity, though lysosomal membrane permeabilization has also been identified as one of the death pathways after exposure to AMF.…”

Section: Discussionmentioning

confidence: 99%

<p>In vitro Ultrasonic Potentiation of 2-Phenylethynesulfonamide/Magnetic Fluid Hyperthermia Combination Treatments for Ovarian Cancer</p>

Mérida¹,

Rinaldi²,

Juan³

et al. 2020

IJN

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Background: Magnetic Fluid Hyperthermia (MFH) is a promising adjuvant for chemotherapy, potentiating the action of anticancer agents. However, drug delivery to cancer cells must be optimized to improve the overall therapeutic effect of drug/MFH combination treatments. Purpose: The aim of this work was to demonstrate the potentiation of 2-phenylethynesulfonamide (PES) at various combination treatments with MFH, using low-intensity ultrasound as an intracellular delivery enhancer. Methods: The effect of ultrasound (US), MFH, and PES was first evaluated individually and then as combination treatments. Definity ® microbubbles and polyethylene glycol (PEG)-coated iron oxide nanoparticles were used to induce cell sonoporation and MFH, respectively. Assessment of cell membrane permeabilization was evaluated via fluorescence microscopy, iron uptake by cells was quantified by UV-Vis spectroscopy, and cell viability was determined using automatic cell counting. Results: Notable reductions in cancer cell viability were observed when ultrasound was incorporated. For example, the treatment US+PES reduced cell viability by 37% compared to the non-toxic effect of the drug. Similarly, the treatment US+MFH using mild hyperthermia (41°C), reduced cell viability by an additional 18% when compared to the effect of MH alone. Significant improvements were observed for the combination of US+PES+MFH with cell viability reduced by an additional 26% compared to the PES+MFH group. The improved cytotoxicity was attributed to enhanced drug/nanoparticle intracellular delivery, with iron uptake values nearly twice those achieved without ultrasound. Various treatment schedules were examined, and all of them showed substantial cell death, indicating that the time elapsed between sonoporation and magnetic field exposure was not significant. Conclusion: Superior cancer cell-killing patterns took place when ultrasound was incorporated thus demonstrating the in vitro ultrasonic potentiation of PES and mild MFH. This work demonstrated that ultrasound is a promising non-invasive enhancer of PES/MFH combination treatments, aiming to establish a sono-thermo-chemotherapy in the treatment of ovarian cancer.

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Section: Discussionmentioning

confidence: 99%

<p>In vitro Ultrasonic Potentiation of 2-Phenylethynesulfonamide/Magnetic Fluid Hyperthermia Combination Treatments for Ovarian Cancer</p>

Mérida¹,

Rinaldi²,

Juan³

et al. 2020

IJN

Self Cite

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“…The magnetic moments of MNPs offer a plausible energetic handle for actuation by AMFs of this amplitude, 10 and experimental evidence has surprisingly indicated that nanoscale heating of MNPs is orders of magnitude greater than what macroscopic heat transport equations predict. 11 Scrutiny of indiscriminate use of linear response theory, the predominant physical model used to describe MNP hysteresis in AMFs, has led to the development and experimental evaluation of more general models. [12][13][14][15][16][17] These systems will likely continue to pose worthwhile fundamental questions and offer opportunities for applications in medicine and elsewhere.…”

Section: Introductionmentioning

confidence: 99%

Practical methods for generating alternating magnetic fields for biomedical research

Christiansen

Howe

Bono

et al. 2017

Review of Scientific Instruments

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Alternating magnetic fields (AMFs) cause magnetic nanoparticles (MNPs) to dissipate heat while leaving surrounding tissue unharmed, a mechanism that serves as the basis for a variety of emerging biomedical technologies. Unfortunately, the challenges and costs of developing experimental setups commonly used to produce AMFs with suitable field amplitudes and frequencies present a barrier to researchers. This paper first presents a simple, cost-effective, and robust alternative for small AMF working volumes that uses soft ferromagnetic cores to focus the flux into a gap. As the experimental length scale increases to accommodate animal models (working volumes of 100s of cm or greater), poor thermal conductivity and volumetrically scaled core losses render that strategy ineffective. Comparatively feasible strategies for these larger volumes instead use low loss resonant tank circuits to generate circulating currents of 1 kA or greater in order to produce the comparable field amplitudes. These principles can be extended to the problem of identifying practical routes for scaling AMF setups to humans, an infrequently acknowledged challenge that influences the extent to which many applications of MNPs may ever become clinically relevant.

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“…In hyperthermia, the magnetic properties of nanoparticles are transferred into heat and dissipated to the surrounding environment, whereas the released energy of particles is corresponding to a hysteresis loop. It is described that the dissipated heat of a magnetite nanoparticle is dependent upon its size and composition, but furthermore, upon the frequency the temperature of the applied field [ 42 ]. The polyR-Fe 3 O 4 achieve 2.5 times higher specific heating power (SHP) than a previously approved contrast agent ferumoxides (Endorem/Feridex ® ) (208 W g −1 vs. 83 W g −1 ) [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

Magnetite-Arginine Nanoparticles as a Multifunctional Biomedical Tool

et al. 2020

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Iron oxide nanoparticles are a promising platform for biomedical applications, both in terms of diagnostics and therapeutics. In addition, arginine-rich polypeptides are known to penetrate across cell membranes. Here, we thus introduce a system based on magnetite nanoparticles and the polypeptide poly-l-arginine (polyR-Fe3O4). We show that the hybrid nanoparticles exhibit a low cytotoxicity that is comparable to Resovist®, a commercially available drug. PolyR-Fe3O4 particles perform very well in diagnostic applications, such as magnetic particle imaging (1.7 and 1.35 higher signal respectively for the 3rd and 11th harmonic when compared to Resovist®), or as contrast agents for magnetic resonance imaging (R2/R1 ratio of 17 as compared to 11 at 0.94 T for Resovist®). Moreover, these novel particles can also be used for therapeutic purposes such as hyperthermia, achieving a specific heating power ratio of 208 W/g as compared to 83 W/g for Feridex®, another commercially available product. Therefore, we envision such materials to play a role in the future theranostic applications, where the arginine ability to deliver cargo into the cell can be coupled to the magnetite imaging properties and cancer fighting activity.

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Nanoscale Thermal Phenomena in the Vicinity of Magnetic Nanoparticles in Alternating Magnetic Fields

Cited by 66 publications

References 74 publications

<p>In vitro Ultrasonic Potentiation of 2-Phenylethynesulfonamide/Magnetic Fluid Hyperthermia Combination Treatments for Ovarian Cancer</p>

<p>In vitro Ultrasonic Potentiation of 2-Phenylethynesulfonamide/Magnetic Fluid Hyperthermia Combination Treatments for Ovarian Cancer</p>

Practical methods for generating alternating magnetic fields for biomedical research

Magnetite-Arginine Nanoparticles as a Multifunctional Biomedical Tool

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