Nanoscale Size Effect of Magnetic Nanocrystals and Their Utilization for Cancer Diagnosis via Magnetic Resonance Imaging

Jun, Young‐wook; Huh, Yong Min; Choi, Jin Woo; Lee, Jae Hyun; Song, Ho Taek; Kim, Sungjun; Yoon, Sarah; Kim, Kyung‐Sup; Shin, Jeon Soo; Suh, Jin Suck; Cheon, Jinwoo

doi:10.1021/ja0422155

Cited by 1,135 publications

(807 citation statements)

References 21 publications

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“…We synthesized and used SPION with a 12-m diameter because an increased size of the SPION results in an increase in the signal intensity in MR imaging (22). Dopamine was used as a capping agent in the surface modification of iron oxide (17).…”

Section: Discussionmentioning

confidence: 99%

Superparamagnetic iron oxide nanoparticles as a dual imaging probe for targeting hepatocytes in vivo

Lee

Jeong

Kim

et al. 2009

Magnetic Resonance in Med

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Hepatocyte-specific targeting agents are useful for evaluation of the hepatocytic function and the monitoring of disease progress. Superparamagnetic iron oxide nanoparticles (SPION) bearing terminal galactose groups exhibit a high affinity for the asialoglycoprotein receptor on the hepatocyte surface. In this study, we synthesized and characterized the dual probe SPION detectable by both nuclear and MR imaging modality for specifically targeting hepatocytes in vivo. SPION with 12-nm diameter were functionalized with dopamine. Surface modification of the SPION was performed to target asialoglycoprotein receptor on hepatocytes, using lactobionic acid. Transmission electron microscope images demonstrated that SPION displayed highly uniform characteristics in terms of both particle size and shape. The X-ray diffraction pattern of SPION revealed a nanocrystal structure of magnetite. To radiolabel the magnetite with 99m Tc, diethylenetriaminepentaacetic acid was conjugated to unreacted functional groups of dopamine. 99m Tc-labeled lactobionic acid-SPION showed high accumulation in liver, with 38.43 ؎ 6.45% injected dose per gram. In MR imaging, the reduction of the T 2 signal in the liver by lactobionic acid-SPION was approximately 50.8 ؎ 7.3%. Competition studies and transmission electron microscope images of liver tissues demonstrated that the lactobionic acid-SPION were localized in hepatocytes. Therefore, the lactobionic acid-SPION may be used as a hepatocyte-targeted dual contrast agent for both nuclear and MR imaging.

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Section: Discussionmentioning

confidence: 99%

Superparamagnetic iron oxide nanoparticles as a dual imaging probe for targeting hepatocytes in vivo

Lee

Jeong

Kim

et al. 2009

Magnetic Resonance in Med

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“…The magnetization of SPIOs can be enhanced by using cores formed by elementary iron or by doping iron oxide with other magnetic elements such as nickel, cobalt and manganese [96,108,109]. Further, the core size of SPIOs can be increased by employing controllable crystallization through thermo-decomposition of iron complex in organic solvents [94,95,109,110].…”

Section: Nanoparticle-based Mri and Mr/pet Imaging Contrast Agentsmentioning

confidence: 99%

“…For example, iron oxide nanoparticles and quantum dots can be synthesized by thermal decomposition of precursor compounds in organic solvents [94,111,112].…”

Section: Nanoparticle-based Mri and Mr/pet Imaging Contrast Agentsmentioning

confidence: 99%

“…However, as-synthesized nanoparticles will aggregate in aqueous buffers unless protected by hydrophilic molecules. In order to disperse in aqueous solutions and be functionalized, the iron oxide core needs to be coated with either natural macromolecules or synthetic polymers [94,98,113]. Although the physical functionality of a nanoparticle is mainly attributable to its crystalline core, the coating plays an indispensible role in the biomedical applications.…”

Section: Nanoparticle-based Mri and Mr/pet Imaging Contrast Agentsmentioning

confidence: 99%

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Engineering imaging probes and molecular machines for nanomedicine

Tong

Cradick

et al. 2012

Sci. China Life Sci.

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Nanomedicine is an emerging field that integrates nanotechnology, biomolecular engineering, life sciences and medicine; it is expected to produce major breakthroughs in medical diagnostics and therapeutics. Due to the size-compatibility of nano-scale structures and devices with proteins and nucleic acids, the design, synthesis and application of nanoprobes, nanocarriers and nanomachines provide unprecedented opportunities for achieving a better control of biological processes, and drastic improvements in disease detection, therapy, and prevention. Recent advances in nanomedicine include the development of functional nanoparticle based molecular imaging probes, nano-structured materials as drug/gene carriers for in vivo delivery, and engineered molecular machines for treating single-gene disorders. This review focuses on the development of molecular imaging probes and engineered nucleases for nanomedicine, including quantum dot bioconjugates, quantum dot-fluorescent protein FRET probes, molecular beacons, magnetic and gold nanoparticle based imaging contrast agents, and the design and validation of zinc finger nucleases (ZFNs) and TAL effector nucleases (TALENs) for gene targeting. The challenges in translating nanomedicine approaches to clinical applications are discussed. Nanomedicine is an emerging field that integrates nanotechnology, biomolecular engineering, biology, and medicine [1]. It focuses on the development of engineered nano-scale (1100 nm) materials, structures and devices for better diagnostics and highly specific medical intervention in curing disease or repairing damaged tissues. As a basis for nanomedicine, nanotechnology is the science, engineering, and technology related to the understanding and control of matter at the nano-scale, and the development of materials, devices, and systems that have novel properties and functions due to their nano-scale dimensions or components. Nanotechnology also provides new abilities to measure, control and manipulate matter (including soft matter) at the nano-scale what was unthinkable with conventional tools. Owing to the size-compatibility of nano-scale structures with proteins and nucleic acids in living cells, nanomedicine approaches have the potential to provide unprecedented opportunities for achieving a better control of biological processes, and drastic improvements in disease detection, therapy, and prevention, thus revolutionizing medicine. Over the last ten years or so, significant efforts have been made in the US, China, Europe and elsewhere to develop nanomedicine. For example, the US National Institutes of Health has developed a nanomedicine centers network, and invested a significant amount of research funding to nanomedicine development. Just in FY 2009 (Oct. 1, 2008Sept. 30, 2009, the total NIH funding in nanotechnology/ nanoscience projects was more than 410 million US dollars. SPECIAL TOPIC

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“…On the other hand, magnetic signals through the human body can be obtained, as in the case of magnetic resonance imaging. 9,10) Thus, magnetic methods are superior to the electrochemical and optical methods. For the abovementioned purpose, we use magnetic particles as a label to detect ions.…”

Section: Introductionmentioning

confidence: 99%

Influence of behaviors of magnetic particles in ferrofluids under alternating magnetic fields on harmonic responses

Oda¹,

Trisnanto²,

Kitamoto³

2018

Jpn. J. Appl. Phys.

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We describe the relationship between the excitation frequency dependence of harmonic signal intensity under alternating magnetic fields and the hydrodynamic size of magnetic particles in ferrofluids. The hydrodynamic size estimated from magnetic susceptibility increases with the increase in ion and particle concentrations in the ferrofluids. The excitation frequency dependence of the fifth-harmonic signal intensity exhibits a minimum point at a certain frequency. The frequency of the minimum point shifts to the lower-frequency range, and after reaching the minimum, it increases with the increase in ion and particle concentrations, reflecting the increase in hydrodynamic size owing to the aggregation of magnetic particles.These behaviors may be useful for applications in ion sensing by a magnetic technique.

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Nanoscale Size Effect of Magnetic Nanocrystals and Their Utilization for Cancer Diagnosis via Magnetic Resonance Imaging

Cited by 1,135 publications

References 21 publications

Superparamagnetic iron oxide nanoparticles as a dual imaging probe for targeting hepatocytes in vivo

Superparamagnetic iron oxide nanoparticles as a dual imaging probe for targeting hepatocytes in vivo

Engineering imaging probes and molecular machines for nanomedicine

Influence of behaviors of magnetic particles in ferrofluids under alternating magnetic fields on harmonic responses

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