Nanoscale profiling of evolving intermolecular interactions in ageing FUS condensates
Alyssa Miller,
Zenon Toprakcioglu,
Seema Qamar
et al.
Abstract:In addition to the native state, proteins can form liquid-like condensates, viscoelastic condensates, such as gels, as well as solid-like condensates, such as amyloid fibrils, crystals and amorphous materials. The material properties of these condensates play important roles in their cellular functions, with aberrant liquid-to-solid phase transitions having been implicated in neurodegenerative diseases. However, the molecular changes and resultant material properties across the whole phase space of condensates… Show more
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