Nanoscale polymer carriers to deliver chemotherapeutic agents to tumours

Cegnar, Mateja; Kristl, Julijana; Kos, Janko

doi:10.1517/14712598.5.12.1557

Cited by 55 publications

(30 citation statements)

References 60 publications

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“…Given their physical characteristics, these materials are used in the chemical, textile, computing, energy, biomedical and pharmaceutical industries (2), in which nanofibers join other, more established drug nanocarriers (53,54). The most commonly used method for nanofiber production is electrospinning-a widely used modern, versatile and one-step method (Fig.…”

Section: The Role Of Interfacial Rheological Characteristics In the Ementioning

confidence: 99%

Interfacial rheology: An overview of measuring techniques and its role in dispersions and electrospinning

Pelipenko¹,

Kristl²,

Rošic³

et al. 2012

Acta Pharmaceutica

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Colloidal disperse systems represent the increasing number of modern delivery systems whose primary characteristic, a large interfacial area, causes thermodynamic instability. Therefore, the foremost challenge in dispersion design is the reduction of interface instability and an understanding of the behaviour of interfaces. Interfacial rheology is one of the most powerful tools for observing occurrences at the interphase. As previously mentioned, the stability of such systems is provided by the formation of a stable interfacial layer of surfactants around each dispersible particle. The stability of these systems can be improved by using more than one surfactant, but it must be kept in mind that different surfactants can have varying mechanisms of stabilisation, some of which can be mutually incompatible. Surfactant selection is therefore crucial and must be based on physicochemical properties, stability of the interfacial film, mobility of the molecules in the interfacial film, HLB, film formation kinetics, compatibility and interactions between molecules on the surface, CMC, etc. Interfacial rheological properties have yet to be thoroughly explored. Only recently, methods have been introduced that provide sufficient sensitivity to reliably determine viscoelastic interfacial properties. In general, interfacial rheology describes the relationship between the deformation of an interface and the stresses exerted on it.Due to the variety in deformations of the interfacial layer (shear and expansions or compressions), the field of interfacial rheology is divided into the subcategories of shear and dilatational rheology. While shear rheology is primarily linked to the long-term stability of dispersions, dilatational rheology provides information regarding short-term stability. Interfacial rheological characteristics become relevant in systems with large interfacial areas, such as emulsions and foams, and in processes that lead to a large increase in the interfacial area, such as electrospinning of nanofibers.

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Section: The Role Of Interfacial Rheological Characteristics In the Ementioning

confidence: 99%

Interfacial rheology: An overview of measuring techniques and its role in dispersions and electrospinning

Pelipenko¹,

Kristl²,

Rošic³

et al. 2012

Acta Pharmaceutica

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“…These delivery vehicles have the potential to augment the pharmacodynamic and pharmacokinetic profiles of drug molecules, thereby enhancing the therapeutic efficacy of the pharmaceutical agents [1]. Further, encapsulating the drug molecule in a delivery system can increase in vivo stability, extend its blood circulation time, and further provide a means for controlling the release of the agent [1]. Moreover, the delivery system can alter the biodistribution of the drug molecule by allowing the agent to accumulate at the tumor site, either passively or actively with targeting [1].…”

Section: Introductionmentioning

confidence: 99%

“…Further, encapsulating the drug molecule in a delivery system can increase in vivo stability, extend its blood circulation time, and further provide a means for controlling the release of the agent [1]. Moreover, the delivery system can alter the biodistribution of the drug molecule by allowing the agent to accumulate at the tumor site, either passively or actively with targeting [1]. In addition to therapeutic drug delivery, serving as diagnostics tools, nanosized carriers can deliver imaging agents to detect and noninvasively diagnose disease.…”

Section: Introductionmentioning

confidence: 99%

Polymersomes: A new multi-functional tool for cancer diagnosis and therapy

Levine

Ghoroghchian

Freudenberg

et al. 2008

Methods

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122

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Nanoparticles are being developed as delivery vehicles for therapeutic pharmaceuticals and contrast imaging agents. Polymersomes (mesoscopic polymer vesicles) possess a number of attractive biomaterial properties that make them ideal for these applications. Synthetic control over block copolymer chemistry enables tunable design of polymersome material properties. The polymersome architecture, with its large hydrophilic reservoir and its thick hydrophobic lamellar membrane, provides significant storage capacity for both water soluble and insoluble substances (such as drugs and imaging probes). Further, the brush-like architecture of the polymersome outer shell can potentially increase biocompatibility and blood circulation times. A further recent advance is the development of multi-functional polymersomes that carry pharmaceuticals and imaging agents simultaneously. The ability to conjugate biologically active ligands to the brush surface provides a further means for targeted therapy and imaging. Hence, polymersomes hold enormous potential as nanostructured biomaterials for future in vivo drug delivery and diagnostic imaging applications.

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“…[219] In addition to nontargeting vector/DNA polyplexes, different vector systems were developed to promote delivery into specific cell populations by incorporation of cell targeting moieties into the vector system. [168,[228][229][230][231] These moieties/ligands (e.g., transferrin, [168,[232][233][234][235][236][237][238][239] epidermal growth factor (EGF), [236,240] arginine-glycine-asparagine (RGD), [241][242][243][244][245] and folate), [242,[246][247][248][249][250] recognize cell type specific receptors in order to direct cellular uptake via receptor-mediated endocytosis, as illustrated in Figure 18. Once bound to the receptors on the cell surface, the vector/DNA polyplexes are internalized by clathrin-dependent endocytosis.…”

Section: Clathrin-mediated Endocytosis (Cme) Is Crucial For Intercellmentioning

confidence: 99%